Zobrazeno 1 - 10
of 387
pro vyhledávání: '"VASANTHA PADMANABHAN"'
Autor:
Sarah Greenwell, Aubree Jones, Yolanda R. Smith, Deanna Marriott, James E. Aikens, Vasantha Padmanabhan, Laura R. Saslow
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Polycystic ovary syndrome (PCOS), the most common endocrine disorder for women of reproductive age, is associated with increased risk for insulin resistance and type 2 diabetes. Current PCOS treatments insufficiently address the s
Externí odkaz:
https://doaj.org/article/abbb86f877154a8aa29cce350380a3cc
Autor:
Kyle A. Campbell, Justin A. Colacino, John Dou, Dana C. Dolinoy, Sung Kyun Park, Rita Loch-Caruso, Vasantha Padmanabhan, Kelly M. Bakulski
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
To distinguish DNA methylation (DNAm) from cell proportion changes in whole placental villous tissue research, we developed a robust cell type-specific DNAm reference to estimate cell composition. We collated new and existing cell type DNAm profiles
Externí odkaz:
https://doaj.org/article/121455ee43c6460883ccfd40de9eae32
Autor:
Soundara Viveka Thangaraj, Adel Ghnenis, Brooke Pallas, Arpita Kalla Vyas, Brigid Gregg, Vasantha Padmanabhan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Lipids play a critical role in neonate development and breastmilk is the newborn’s major source of lipids. Milk lipids directly influence the neonate plasma lipid profile. The milk lipidome is dynamic, influenced by maternal factors and re
Externí odkaz:
https://doaj.org/article/04dea998628d4f828347517ceb41d395
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Gestational hyperandrogenism is a risk factor for adverse maternal and offspring outcomes with effects likely mediated in part via disruptions in maternal lipid homeostasis. Using a translationally relevant sheep model of gestational testost
Externí odkaz:
https://doaj.org/article/376da02f908f4cb28ba81eafcec29842
Autor:
Rebekah L. Petroff, Dana C. Dolinoy, Kai Wang, Luke Montrose, Vasantha Padmanabhan, Karen E. Peterson, Douglas M. Ruden, Maureen A. Sartor, Laurie K. Svoboda, Martha M. Téllez-Rojo, Jaclyn M. Goodrich
Publikováno v:
Environment International, Vol 186, Iss , Pp 108575- (2024)
Although toxicology uses animal models to represent real-world human health scenarios, a critical translational gap between laboratory-based studies and epidemiology remains. In this study, we aimed to understand the toxicoepigenetic effects on DNA m
Externí odkaz:
https://doaj.org/article/250e66bb854f46d58bad6a02891c8046
Autor:
Nadia Saadat, Fernando Aguate, Alexandra Nowak, Suzanne Hyer, Todd Lydic, Gustavo de los Campos, Vasantha Padmanabhan, Dawn Misra, Carmen Giurgescu
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 135-136 (2024)
OBJECTIVES/GOALS: Pregnant African American (Black women) have higher rates of adverse pregnancy outcomes compared to other races and routine monitoring of lipid levels is not currently in practice in prenatal care. We hypothesized that lipid profile
Externí odkaz:
https://doaj.org/article/745fcf3286cc49e08a11b43496cd3659
Autor:
Wenhui Song, Qing Guo, Muraly Puttabyatappa, Venkateswaran Ramamoorthi Elangovan, Jianping Wang, Fang Li, Fangfang Liu, Xuejie Bi, Haiying Li, Guangping Fu, Vasantha Padmanabhan, XiaoHua Wu
Publikováno v:
Heliyon, Vol 10, Iss 6, Pp e28007- (2024)
Fetal growth restriction (FGR) is one of the most common pregnancy complications culminating in adverse fetal outcome, including preterm birth, neonatal mortality and stillbirth. Compromised placental development and function, especially disruption i
Externí odkaz:
https://doaj.org/article/1315f4fc934f48a0801db056e37039f7
Autor:
Rebekah L. Petroff, Raymond G. Cavalcante, Elizabeth S. Langen, Dana C. Dolinoy, Vasantha Padmanabhan, Jaclyn M. Goodrich
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-22 (2023)
Abstract Background Per- and polyfluoroalkyl substances (PFAS) are chemicals that are resistant to degradation and ubiquitous in our environments. PFAS may impact the developing epigenome, but current human evidence is limited to assessments of total
Externí odkaz:
https://doaj.org/article/2f6b54a4ece048e8b8e796f9e4d7fda5
Autor:
Kyle A. Campbell, Justin A. Colacino, Muraly Puttabyatappa, John F. Dou, Elana R. Elkin, Saher S. Hammoud, Steven E. Domino, Dana C. Dolinoy, Jaclyn M. Goodrich, Rita Loch-Caruso, Vasantha Padmanabhan, Kelly M. Bakulski
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
A single-cell RNA-seq analysis of placental villous tissue provides a deconvolution reference atlas of fetal and maternal placental cell types, and indicates that placental cellular heterogeneity in preeclampsia might contribute to differences in bul
Externí odkaz:
https://doaj.org/article/90cfef689cef403cb9f09dce9d9d921b
Autor:
Venkateswaran Ramamoorthi Elangovan, Nadia Saadat, Adel Ghnenis, Vasantha Padmanabhan, Arpita K. Vyas
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Adverse in-utero insults during fetal life alters offspring’s developmental trajectory, including that of the cardiovascular system. Gestational hyperandrogenism is once such adverse in-utero insult. Gestational testosterone (T)-treatment,
Externí odkaz:
https://doaj.org/article/c1508a7ffee1456091c4041b9c060e2c