Germline-driven replication repair-deficient higt-grade gliomas exhibit unique hypomethylation patterns

Autor: DODGSHUN AJ, FUKUOKA K, EDWARDS M, BIANCHI V, DAS A, SEXTON-OATES A, LAROUCHE V, VANAN MI, LINDHORST S, YALON M, MASON G, CROOKS BK, CONSTANTINI S, MASSIMINO M, CHIARAVALLI S, RAMDAS J, MASON W, ASHRAF S, FARAH R, VAN DAMME An, OPOCHER E

Publikováno v: Acta neuropathol, Vol. 140, no.5, p. 765-776 (2020)

Germline-driven replication repair-deficient higt-grade gliomas exhibit unique hypomethylation patterns

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1493::cde1d7338857b0450c42707f8e629eb4
https://hdl.handle.net/2078.1/237276

Case report: Slipped capital femoral epiphysis: a rare adverse event associated with FGFR tyrosine kinase inhibitor therapy in a child.

Autor: Brizini M; Division of Pediatric Hematology-Oncology, Cancer Care Manitoba, Winnipeg, MB, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada., Drimes T; Division of Nursing, Cancer Care Manitoba, Winnipeg, MB, Canada., Bourne C; Division of Nursing, Cancer Care Manitoba, Winnipeg, MB, Canada., Streilein J; Division of Pharmacy, Cancer Care Manitoba, Winnipeg, MB, Canada., Drapeau A; Section of Neuro-Surgery, University of Manitoba, Winnipeg, MB, Canada., Wrogemann J; Department of Radiology, University of Manitoba, Winnipeg, MB, Canada., Archer LA; Section of Orthopedic Surgery, University of Manitoba, Winnipeg, MB, Canada., Del Bigio M; Department of Pathology, University of Manitoba, Winnipeg, MB, Canada., Vanan MI; Division of Pediatric Hematology-Oncology, Cancer Care Manitoba, Winnipeg, MB, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.; Paul Albrechtsen Research Institute, Cancer Care Manitoba, Winnipeg, MB, Canada.

Publikováno v: Frontiers in oncology [Front Oncol] 2024 May 24; Vol. 14, pp. 1399356. Date of Electronic Publication: 2024 May 24 (Print Publication: 2024).

Genomic Microsatellite Signatures Identify Germline Mismatch Repair Deficiency and Risk of Cancer Onset.

Autor: Chung J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Negm L; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Bianchi V; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Stengs L; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Das A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.; Department of Pediatric Hematology/Oncology, Tata Medical Centre, Kolkata, India., Liu ZA; Department of Biostatistics, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Sudhaman S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Aronson M; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, Canada., Brunga L; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada., Edwards M; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Forster V; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Komosa M; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Davidson S; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada., Lees J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Tomboc P; Department of Pediatrics, West Virginia University, Morgantown, WV., Samuel D; Valley Children's Hospital, Madera, CA., Farah R; Lebanese American University Medical Center-Rizk, Beirut, Lebanon., Bendel A; Department of Pediatric Hematology-Oncology, Children's Minnesota, Minneapolis, MN., Knipstein J; Division of Pediatric Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, WI., Schneider KW; Department of Pediatric Hematology-Oncology, Children's Hospital Colorado, Aurora, CO., Reschke A; Department of Pediatric Hematology/Oncology, Stanford University, Palo Alto, CA., Zelcer S; Department of Pediatrics, London Health Sciences Centre, London, ON, Canada., Zorzi A; Division of Haematology/Oncology, Western University, London, ON, Canada., McWilliams R; Department of Oncology, Mayo Clinic, Rochester, MN., Foulkes WD; Departments of Oncology and Human Genetics, McGill University Health Centre, Cancer Genetics Program, Montreal, QC, Canada., Bedgood R; Coliseum Medical Centers, Macon, GA., Peterson L; Division of Medical Oncology, Washington University, St Louis, MO., Rhode S; Department of Hematology and Oncology, Cleveland Clinic, Cleveland, OH., Van Damme A; Pediatric Gastroenterology and Hepatology Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium., Scheers I; Universite Catholique de Louvain La Faculte de Medecine, Bruxelles, Belgium., Gardner S; Department of Pediatric Hematology-Oncology, NYU Langone Health, New York, NY., Robbins G; Department of Pediatric Hematology-Oncology, NYU Langone Health, New York, NY., Vanan MI; Department of Pediatric Hematology-Oncology, CancerCare Manitoba, Winnipeg, MB, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada., Meyn MS; Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, ON, Canada.; Center for Human Genomics and Precision Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI., Auer R; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Leach B; Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH., Burke C; Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH., Villani A; Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Malkin D; Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Bouffet E; Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada., Huang A; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Taylor MD; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada., Durno C; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, ON, Canada.; Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, ON, Canada., Shlien A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Hawkins C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada., Getz G; The Broad Institute of MIT and Harvard, Cambridge, MA.; Center for Cancer Research, Massachusetts General Hospital, Boston, MA.; Harvard Medical School, 250 Longwood Avenue, Boston, MA.; Department of Pathology, Massachusetts General Hospital, Boston, MA., Maruvka YE; Faculty of Biotechnology and Food Engineering, The Lokey Center for Life Science and Engineering, TECHNION - Israel Institute of Technology, Haifa, Israel., Tabori U; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2023 Feb 01; Vol. 41 (4), pp. 766-777. Date of Electronic Publication: 2022 Oct 14.

Spermidine/Spermine N1-Acetyltransferase 1 ( SAT1 )-A Potential Gene Target for Selective Sensitization of Glioblastoma Cells Using an Ionizable Lipid Nanoparticle to Deliver siRNA.

Autor: Yathindranath V; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB R3E 0Z3, Canada., Safa N; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB R3E 0Z3, Canada., Sajesh BV; Cancer Care Manitoba Research Institute-CCMRI, Winnipeg, MB R3E 0V9, Canada., Schwinghamer K; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66047, USA., Vanan MI; Cancer Care Manitoba Research Institute-CCMRI, Winnipeg, MB R3E 0V9, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3T 2N2, Canada., Bux R; BioMark Diagnostics Inc., Richmond, BC V6X 2W2, Canada., Sitar DS; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB R3E 0Z3, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.; Department of Internal Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada., Pitz M; Cancer Care Manitoba Research Institute-CCMRI, Winnipeg, MB R3E 0V9, Canada.; Department of Internal Medicine, University of Manitoba, Winnipeg, MB R3E 0V9, Canada., Siahaan TJ; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66047, USA., Miller DW; Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB R3E 0Z3, Canada.

Publikováno v: Cancers [Cancers (Basel)] 2022 Oct 22; Vol. 14 (21). Date of Electronic Publication: 2022 Oct 22.

Selumetinib for symptomatic, inoperable plexiform neurofibromas in children with neurofibromatosis type 1: A national real-world case series.

Autor: Coltin H; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.; Programme in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada., Perreault S; Division of Child Neurology, Department of Pediatrics, CHU Sainte-Justine, Montreal, Quebec, Canada., Larouche V; Division of Hemato-Oncology, Department of Pediatrics, Centre Hospitalier Universitaire de Québec-Université Laval, Québec City, Quebec, Canada., Black K; Pediatric Oncology/Neuro-Oncology Clinics, Northern Alberta Children's Cancer Program, Stollery Children's Hospital, Edmonton, Alberta, Canada., Wilson B; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada., Vanan MI; Division of Pediatric Hematology-Oncology, Cancer Care Manitoba, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada., Gupta AA; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada., Morgenstern DA; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada., Parkin PC; Division of Paediatric Medicine, Hospital for Sick Children, Toronto, Ontario, Canada., Bouffet E; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada., Ramaswamy V; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.; Programme in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.; Departments of Medical Biophysics and Paediatrics, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Pediatric blood & cancer [Pediatr Blood Cancer] 2022 Aug; Vol. 69 (8), pp. e29633. Date of Electronic Publication: 2022 Mar 15.