Synthesis, Pharmacological Characterization, and Molecular Modeling of Heterobicyclic Amino Acids Related to (+)-2-Aminobicyclo[3.1.0]hexane- 2,6-dicarboxylic Acid (LY354740):  Identification of Two New Potent, Selective, and Systemically Active Agonists for Group II Metabotropic Glutamate Receptors

Autor: Monn, J. A., Valli, M. J., Massey, S. M., Hansen, M. M., Kress, T. J., Wepsiec, J. P., Harkness, A. R., Grutsch, J. L., Jr., Wright, R. A., Johnson, B. G., Andis, S. L., Kingston, A., Tomlinson, R., Lewis, R., Griffey, K. R., Tizzano, J. P., Schoepp, D. D.

Publikováno v: Journal of Medicinal Chemistry; March 25, 1999, Vol. 42 Issue: 6 p1027-1040, 14p

Synthesis of the Four Isomers of 4-Aminopyrrolidine-2,4-dicarboxylate:  Identification of a Potent, Highly Selective, and Systemically-Active Agonist for Metabotropic Glutamate Receptors Negatively Coupled to Adenylate Cyclase

Autor: Monn, J. A., Valli, M. J., Johnson, B. G., Salhoff, C. R., Wright, R. A., Howe, T., Bond, A., Lodge, D., Spangle, L. A., Paschal, J. W., Campbell, J. B., Griffey, K., Tizzano, J. P., Schoepp, D. D.

Publikováno v: Journal of Medicinal Chemistry; July 19, 1996, Vol. 39 Issue: 15 p2990-3000, 11p

Group II metabotropic glutamate receptor (mGlu2 and mGlu3) roles in thalamic processing.

Autor: Copeland, Caroline S.^1,2 (AUTHOR) caroline.copeland@kcl.ac.uk, Neale, Stuart A.³ (AUTHOR), Nisenbaum, Eric S.⁴ (AUTHOR), Salt, Thomas E.^2,3 (AUTHOR)

Publikováno v: British Journal of Pharmacology. Apr2022, Vol. 179 Issue 8, p1607-1619. 13p. 1 Diagram, 4 Graphs.

The highly selective mGlu2 receptor positive allosteric modulator LY‐487,379 alleviates l‐DOPA‐induced dyskinesia in the 6‐OHDA‐lesioned rat model of Parkinson's disease.

Autor: Hamadjida, Adjia¹ (AUTHOR), Sid‐Otmane, Lamia² (AUTHOR), Kwan, Cynthia¹ (AUTHOR), Frouni, Imane^1,2 (AUTHOR), Nafade, Vaidehi¹ (AUTHOR), Bédard, Dominique¹ (AUTHOR), Gagnon, Dave³ (AUTHOR), Wallman, Marie‐Josée³ (AUTHOR), Rouillard, Claude⁴ (AUTHOR), Parent, André³ (AUTHOR), Parent, Martin³ (AUTHOR), Huot, Philippe^1,2,5,6 (AUTHOR) philippe.huot@mcgill.ca

Publikováno v: European Journal of Neuroscience. Jun2020, Vol. 51 Issue 12, p2412-2422. 11p. 1 Diagram, 5 Graphs.

The highly selective mGlu 2 receptor positive allosteric modulator LY-487,379 alleviates l-DOPA-induced dyskinesia in the 6-OHDA-lesioned rat model of Parkinson's disease.

Autor: Hamadjida A; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada., Sid-Otmane L; Département de Pharmacologie et Physiologie, Université de Montréal, Montreal, QC, Canada., Kwan C; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada., Frouni I; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada.; Département de Pharmacologie et Physiologie, Université de Montréal, Montreal, QC, Canada., Nafade V; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada., Bédard D; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada., Gagnon D; Centre de Recherche CERVO, Quebec City, QC, Canada., Wallman MJ; Centre de Recherche CERVO, Quebec City, QC, Canada., Rouillard C; Centre de Recherche du Centre Hospitalier Universitaire de Québec, Quebec City, QC, Canada., Parent A; Centre de Recherche CERVO, Quebec City, QC, Canada., Parent M; Centre de Recherche CERVO, Quebec City, QC, Canada., Huot P; Neurodegenerative Disease Group, Montreal Neurological Institute, Montreal, QC, Canada.; Département de Pharmacologie et Physiologie, Université de Montréal, Montreal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.; Movement Disorder Clinic, Division of Neurology, Department of Neuroscience, McGill University Health Centre, Montreal, QC, Canada.

Publikováno v: The European journal of neuroscience [Eur J Neurosci] 2020 Jun; Vol. 51 (12), pp. 2412-2422. Date of Electronic Publication: 2020 Feb 12.