Zobrazeno 1 - 10
of 36
pro vyhledávání: '"VALENTINE COMAILLS"'
Publikováno v:
Biology, Vol 12, Iss 5, p 671 (2023)
The integrity of the genome is crucial for the survival of all living organisms. However, genomes need to adapt to survive certain pressures, and for this purpose use several mechanisms to diversify. Chromosomal instability (CIN) is one of the main m
Externí odkaz:
https://doaj.org/article/121be11d8d1d4c6abcf3470aa166c183
Autor:
Eugenia Martin Vázquez, Nadia Cobo-Vuilleumier, Raquel Araujo Legido, Sandra Marín-Cañas, Emanuele Nola, Akaitz Dorronsoro, Lucia López Bermudo, Alejandra Crespo, Silvana Y. Romero-Zerbo, Maria García-Fernández, Alejandro Martin Montalvo, Anabel Rojas, Valentine Comaills, Francisco J. Bérmudez-Silva, Maureen Gannon, Franz Martin, Decio Eizirik, Petra I. Lorenzo, Benoit R. Gauthier
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104345- (2022)
Summary: LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse models of Type 1 Diabetes Mellitus. Islet transcriptome profiling re
Externí odkaz:
https://doaj.org/article/8058666987f74aa8a44031e045ebfaf8
Autor:
Ken Tajima, Satoru Matsuda, Toshifumi Yae, Benjamin J. Drapkin, Robert Morris, Myriam Boukhali, Kira Niederhoffer, Valentine Comaills, Taronish Dubash, Linda Nieman, Hongshan Guo, Neelima K. C. Magnus, Nick Dyson, Toshihiro Shioda, Wilhelm Haas, Daniel A. Haber, Shyamala Maheswaran
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
SETD1A, a histone H3K4 methyltransferase that promotes gene expression, is required for embryonic development. Here, the authors show that SETD1A regulates the expression of mitotic genes and that SETD1A suppression induces senescence.
Externí odkaz:
https://doaj.org/article/21e385ead60048f085bedca5bc235b72
Autor:
Benoit R. Gauthier, Valentine Comaills
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7281 (2021)
The dynamic nature of the nuclear envelope (NE) is often underestimated. The NE protects, regulates, and organizes the eukaryote genome and adapts to epigenetic changes and to its environment. The NE morphology is characterized by a wide range of div
Externí odkaz:
https://doaj.org/article/3402b020e7f5462599bd61edf16b3bfd
Autor:
Yu Zheng, David T. Miyamoto, Ben S. Wittner, James P. Sullivan, Nicola Aceto, Nicole Vincent Jordan, Min Yu, Nezihi Murat Karabacak, Valentine Comaills, Robert Morris, Rushil Desai, Niyati Desai, Erin Emmons, John D. Milner, Richard J. Lee, Chin-Lee Wu, Lecia V. Sequist, Wilhelm Haas, David T. Ting, Mehmet Toner, Sridhar Ramaswamy, Shyamala Maheswaran, Daniel A. Haber
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Circulating tumour cells contribute to metastatic spread. Here the authors find that beta-chain of haemoglobin is overexpressed in those cells and protects them from oxidative stress, prolonging their survival in circulation and thereby increasing th
Externí odkaz:
https://doaj.org/article/1b34881d11b34839baa13a42e1ec312c
Autor:
Marco Piva, Giacomo Domenici, Oihana Iriondo, Miriam Rábano, Bruno M Simões, Valentine Comaills, Inmaculada Barredo, Jose A López‐Ruiz, Ignacio Zabalza, Robert Kypta, Maria d M Vivanco
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 1, Pp 66-79 (2013)
Abstract Development of resistance to therapy continues to be a serious clinical problem in breast cancer management. Cancer stem/progenitor cells have been shown to play roles in resistance to chemo‐ and radiotherapy. Here, we examined their role
Externí odkaz:
https://doaj.org/article/42b2c474b81e4b609e38a99f1375b5d6
Autor:
Shyamala Maheswaran, Daniel A. Haber, Mehmet Toner, Sridhar Ramaswamy, Beverly Moy, David T. Ting, Ravi Kapur, Dennis Sgroi, Toshi Shioda, Olivia Mackenzie, Huili Zhu, Kira Niederhoffer, Valentine Comaills, Yu Zheng, Francesca Bersani, Amanda Engstrom, Ryan O'Keefe, Maria C. Donaldson, Ben S. Wittner, Aditya Bardia, Nicola Aceto
Supplementary Table S1: Patients and clinical information. Supplementary Table S2: Genes used to determine the AR signature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e33c08ccde0e98ddafd38db848965d
https://doi.org/10.1158/1541-7786.22513614.v1
https://doi.org/10.1158/1541-7786.22513614.v1
Autor:
Shyamala Maheswaran, Daniel A. Haber, Mehmet Toner, Sridhar Ramaswamy, Beverly Moy, David T. Ting, Ravi Kapur, Dennis Sgroi, Toshi Shioda, Olivia Mackenzie, Huili Zhu, Kira Niederhoffer, Valentine Comaills, Yu Zheng, Francesca Bersani, Amanda Engstrom, Ryan O'Keefe, Maria C. Donaldson, Ben S. Wittner, Aditya Bardia, Nicola Aceto
Supplementary Figure S1: RNA sequencing and pathway analysis of CTCs from Bone(+) versus Visceral(+) breast cancer patients. Supplementary Figure S2: Correlation between AR expression and AR signatures. Supplementary Figure S3: ER and PR expression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57bcb22f6f41dd87c04574d8f01ab6e8
https://doi.org/10.1158/1541-7786.22513617.v1
https://doi.org/10.1158/1541-7786.22513617.v1
Autor:
Antonio Campos-Caro, Eduardo García Fuentes, Francisco Javier Bermúdez-Silva, Nadia Cobo-Vuilleumier, Petra I. Lorenzo, Christian Claude Lachaud, Benoit R. Gauthier, Valentine Comaills, Esther Fuente-Martin, Jose C. Reyes, Alejandro Martin-Montalvo, Alejandra Crespo Barreda, José A Guerrero Martínez, Sabrina Rivero Canalejo, Jesús Ángel Pérez-Cabello, Franz Martín, Manuel Álvarez Dolado, José Manuel Mellado-Gil, Eugenia Martin Vázquez, Gemma Rojo-Martínez, Silvana Y. Romero-Zerbo, David Pozo, Jaime M. Franco, Manuel Aguilar-Diosdado, Livia López-Noriega
Publikováno v:
Theranostics
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Rationale: We recently demonstrated that the Metabesity factor HMG20A regulates islet beta-cell functional maturity and adaptation to physiological stress such as pregnancy and pre-diabetes. HMG20A also dictates central nervous system (CNS) developme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353d6c4b8b7acf4f3e6f9f951fd6d22d
https://doi.org/10.7150/thno.57237
https://doi.org/10.7150/thno.57237
Autor:
Nezihi Murat Karabacak, Yu Zheng, Taronish D. Dubash, Risa Burr, Douglas S. Micalizzi, Ben S. Wittner, Maoxuan Lin, Devon F. Wiley, Valentine Comaills, Erin Emmons, Kira L. Niederhoffer, Uyen Ho, Jacob Ukleja, Dante Che, Hannah Stowe, Linda T. Nieman, Wilhelm Haas, Shannon L. Stott, Michael S. Lawrence, David T. Ting, David T. Miyamoto, Daniel A. Haber, Mehmet Toner, Shyamala Maheswaran
Publikováno v:
Cancer Res
Cancer therapy often results in heterogeneous responses in different metastatic lesions in the same patient. Inter- and intratumor heterogeneity in signaling within various tumor compartments and its impact on therapy are not well characterized due t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052b3467e5154410f7e70bde0f193ddb
https://europepmc.org/articles/PMC8930560/
https://europepmc.org/articles/PMC8930560/