Zobrazeno 1 - 10
of 80
pro vyhledávání: '"VALENTINA PIRRO"'
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102884- (2024)
Summary: Here, we present a targeted polar metabolomics protocol for the analysis of biofluids and frozen tissue biopsies using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). We describe steps for sample pretreatment, liquid-
Externí odkaz:
https://doaj.org/article/717b777eadda4a9e8229b6382f91db54
Autor:
Ricardo J. Samms, GuoFang Zhang, Wentao He, Olga Ilkayeva, Brian A. Droz, Steven M. Bauer, Cynthia Stutsman, Valentina Pirro, Kyla A. Collins, Ellen C. Furber, Tamer Coskun, Kyle W. Sloop, Joseph T. Brozinick, Christopher B. Newgard
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101550- (2022)
Objectives: Tirzepatide, a dual GIP and GLP-1 receptor agonist, delivered superior glycemic control and weight loss compared to selective GLP-1 receptor (GLP-1R) agonism in patients with type 2 diabetes (T2D). These results have fueled mechanistic st
Externí odkaz:
https://doaj.org/article/6166df01a101493baa9fce8714c6b27b
Autor:
Eugenio Alladio, Agnieszka Martyna, Alberto Salomone, Valentina Pirro, Marco Vincenti, Grzegorz Zadora
Publikováno v:
Data in Brief, Vol 12, Iss C, Pp 1-8 (2017)
The concentration values of direct and indirect biomarkers of ethanol consumption were detected in blood (indirect) or hair (direct) samples from a pool of 125 individuals classified as either chronic (i.e. positive) and non-chronic (i.e. negative) a
Externí odkaz:
https://doaj.org/article/24ce6b46590b478a87559da3087b5acd
Autor:
Alan K Jarmusch, Clint M Alfaro, Valentina Pirro, Eyas M Hattab, Aaron A Cohen-Gadol, R Graham Cooks
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163180 (2016)
Desorption electrospray ionization-mass spectrometry (DESI-MS) imaging was used to analyze unmodified human brain tissue sections from 39 subjects sequentially in the positive and negative ionization modes. Acquisition of both MS polarities allowed m
Externí odkaz:
https://doaj.org/article/aae3f2cfae8f45e6a011dddd34e620fe
Autor:
Andrés Felipe González-Serrano, Valentina Pirro, Christina R Ferreira, Paolo Oliveri, Livia S Eberlin, Julia Heinzmann, Andrea Lucas-Hahn, Heiner Niemann, Robert Graham Cooks
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74981 (2013)
Alteration of maternal lipid metabolism early in development has been shown to trigger obesity, insulin resistance, type 2 diabetes and cardiovascular diseases later in life in humans and animal models. Here, we set out to determine (i) lipid composi
Externí odkaz:
https://doaj.org/article/af5e118671d54bac915538feeeeddd4c
Autor:
Kenneth D. Roth, Valentina Pirro, Kevin L. Duffin, Jonathan M. Wilson, Yanzhu Lin, Jill A. Willency, Axel Haupt, Paul L. Milligan, Christopher B. Newgard, Giacomo Ruotolo
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:363-378
Context Tirzepatide substantially reduced hemoglobin A1c (HbA1c) and body weight in subjects with type 2 diabetes (T2D) compared with the glucagon-like peptide 1 receptor agonist dulaglutide. Improved glycemic control was associated with lower circul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3140a92fd3671aef505b0ff756594a2c
https://doi.org/10.1210/clinem/dgab722
https://doi.org/10.1210/clinem/dgab722
Autor:
VALENTINA PIRRO, GUILLAUME PARE, SHUN FU LEE, HELEN M. COLHOUN, YANZHU LIN, JONATHAN M. WILSON, HUI-RONG QIAN, ANASTASIA HOOVER, KEVIN L. DUFFIN, HERTZEL C. GERSTEIN
Publikováno v:
Diabetes. 71
Dulaglutide (DU) reduced the risk of CV outcomes compared with placebo (PL) in the REWIND trial (NCT01394952) , with a MACE-3 (major adverse CV events) hazard ratio of 0.88 over 5.4 years. Participants were ≥50 years of age with T2D, A1C ≤9.5%, B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65cebcb7b6528af1f96439f31cfed9f8
https://doi.org/10.2337/db22-731-p
https://doi.org/10.2337/db22-731-p
Autor:
JONATHAN M. WILSON, GUILLAUME PARE, SHUN FU LEE, HELEN M. COLHOUN, HUI-RONG QIAN, VALENTINA PIRRO, ANASTASIA HOOVER, MARK LAKSHMANAN, GIACOMO RUOTOLO, KEVIN L. DUFFIN, HERTZEL C. GERSTEIN
Publikováno v:
Diabetes. 71
In the REWIND trial, dulaglutide (DU) reduced the risk of CV outcomes compared with placebo (PL) (Major Adverse Cardiovascular Event [MACE]-3 hazard ratio 0.88) . This post hoc analysis studied circulating protein biomarkers associated with CV events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::406a813d146475b65a3c3fbd37a0f23f
https://doi.org/10.2337/db22-725-p
https://doi.org/10.2337/db22-725-p
Autor:
Valeria Luzzi, Federica Altieri, Gabriele Di Carlo, Mariana Guaragna, Valentina Pirro, Beatrice Marasca, Luisa Cotticelli, Marta Mazur, Paola Di Giacomo, Carlo Di Paolo, Marco Brunori, Gabriele Piperno, Giuseppe Magliulo, Agnese Martini, Emma Pietrafesa, Antonella Polimeni
Publikováno v:
International Journal of Environmental Research and Public Health; Volume 19; Issue 9; Pages: 5517
Introduction: OSAS is an emerging public health problem. Early diagnosis in adults with comorbidities is the gold standard to avoid complications caused by a late diagnosis. The aim of the study, part of the SLeeP@SA project, was to identify within a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942207d5de29a50b12efc112bfe99476
Autor:
R. G. Cooks, Fernanda Bertuccez Cordeiro, Marisol León, Maria Angélica Miglino, Livia S. Eberlin, Valentina Pirro, Alan K. Jarmusch, Christina R. Ferreira, J. E. Hallett
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Merging optical images of tissue sections with the spatial distributions of molecules seen by imaging mass spectrometry is a powerful approach to better understand the metabolic roles of the mapped molecules. Here, we use histologically friendly deso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f88da7579f2450acc79b6e3fe127ddb
https://doi.org/10.1007/s00216-019-02352-6
https://doi.org/10.1007/s00216-019-02352-6