Zobrazeno 1 - 10
of 118
pro vyhledávání: '"V.W. Pentreath"'
Publikováno v:
Toxicology in Vitro. 9:39-48
Primary cultures of rat cortical astrocytes were exposed to 25 neurotoxic and non-neurotoxic compounds for 24 hr over a concentration range of 0.001 to 1000 μg/ml and the effects were quantified using the MTT assay. EC50 values were obtained for nin
Autor:
V.W. Pentreath
Publikováno v:
Transactions of the Royal Society of Tropical Medicine and Hygiene. 89:9-15
Damage to the nervous system occurs in both African and American trypanosomiases, but it differs considerably in form and extent in each disease, and with different strains and disease stages. With Trypanosoma brucei infections there is a progressive
Autor:
S.P. Williams, S. O'Hare, M.R. Cookson, C.K. Atterwill, Michael J. Garle, V.W. Pentreath, R. McClean, C. Egan, J. Davenport-Jones
Publikováno v:
Toxicology in Vitro. 8:799-802
In the absence of a formal in vitro alternative model for neurotoxicity testing, the CellTox Centre, in collaboration with the University of Salford, FRAME and the EEC, has set up an initial pre-validation trial of a three-tiered scheme that was orig
Autor:
M.R. Cookson, V.W. Pentreath
Publikováno v:
Toxicology in Vitro. 8:351-359
Astrocyte-enriched primary glial cell cultures from the rat cerebral cortex were exposed to a range of neurotoxic compounds and the effects on three proteins were examined by enzyme-linked immunosorbent assay (ELISA). The most consistent marker for a
Publikováno v:
Transactions of the Royal Society of Tropical Medicine and Hygiene. 84:795-799
To help to elucidate the changes induced by Trypanosoma brucei gambiense in the central nervous system (CNS) in advanced sleeping sickness patients, levels of interleukin-1 (IL-1) and prostaglandins D2 (PGD2) and E2 (PGE2) were measured by radioimmun
Publikováno v:
Experimental parasitology. 119(2)
The potential role of phospholipases in trypanosomiasis was investigated using bee venom phospholipase A2 (bvPLA2) as a model. The effects of bvPLA2 on the survival of Trypanosoma brucei brucei , 2 h and 12 h cultures of Enterobacter cloacae , Escher
Autor:
V.W Pentreath, N.D Slamon
Publikováno v:
Chemico-biological interactions. 127(3)
The effects of pretreatment with the antioxidants reduced glutathione (GSH), ascorbate (ASC), Trolox (TROL), and combined ascorbate and Trolox (ASC/TROL) exposure on the acute (24 h) toxicities (EC50 value) of the antidepressants amitriptyline, imipr
Preliminary observations on the intestinal pathology of mice infected with Trypanosoma brucei brucei
Autor:
J.N. Nyakundi, V.W. Pentreath
Publikováno v:
Transactions of the Royal Society of Tropical Medicine and Hygiene. 93(6)
Autor:
V.W. Pentreath
Publikováno v:
Transactions of the Royal Society of Tropical Medicine and Hygiene. 85:145-147
Autor:
M.R. Cookson, V.W. Pentreath
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 10(3)
The neurotoxic effects of mercury (II) chloride, methylmercury (MeHg) and cadmium chloride on astrocytes were modelled using C6 glioma cell cultures. All three compounds were cytotoxic to these cells with an order of potency of cadmium > MeHg > mercu