Zobrazeno 1 - 10
of 31
pro vyhledávání: '"V.M. Mahnir"'
Autor:
Jon Lindstrom, Hong Xing, V.M. Mahnir, William R. Kem, Kristin W. Andrud, Bjarne Gabrielsen, Stephen T. Lee, Linda B. Bloom, Benedict T. Green
Publikováno v:
Marine Drugs, Vol 17, Iss 11, p 614 (2019)
Marine Drugs
Volume 17
Issue 11
Marine Drugs
Volume 17
Issue 11
Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddb6d6f713ef5f910f2d6f3fe2545e3
https://www.mdpi.com/1660-3397/17/11/614
https://www.mdpi.com/1660-3397/17/11/614
Autor:
V.M. Mahnir, M. E. Byrnes, William R. Kem, W .A. Volberg, Ilya Khaytin, D.S. Krafte, William P. Gorczyca, I. Zaydenberg, Michael W. Pennington, R. Hill, J. de Chastonay
Publikováno v:
International Journal of Peptide and Protein Research. 46:354-358
ShK-toxin, a 35 residue peptide isolated from the sea anemone Stichodactyla helianthus, was synthesized using an Fmoc strategy and successfully folded to the biologically active form containing three intramolecular disulfide bonds. The ability of syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bd44f894a140117f8f73f6b4ed18a3
https://doi.org/10.1111/j.1399-3011.1995.tb01068.x
https://doi.org/10.1111/j.1399-3011.1995.tb01068.x
Autor:
Heiko Rauer, K. Kalman, Kathy Paschetto, Angela Nguyen, Edward P. Christian, Michael D. Cahalan, George A. Gutman, William R. Kem, Raymond S. Norton, Michael W. Pennington, V.M. Mahnir, K. George Chandy, Mark D. Lanigan, Stephan Grissmer
Publikováno v:
Journal of Biological Chemistry. 273:32697-32707
The voltage-gated potassium channel in T lymphocytes, Kv1.3, is an important molecular target for immunosuppressive agents. A structurally defined polypeptide, ShK, from the sea anemone Stichodactyla helianthus inhibited Kv1.3 potently and also block
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7b612592cdc394456df7f7fedca46b
https://doi.org/10.1074/jbc.273.49.32697
https://doi.org/10.1074/jbc.273.49.32697
Publikováno v:
Biopharmaceutics & Drug Disposition. 19:147-151
DMXBA (3-(2,4-dimethoxybenzylidene)-anabaseine, also known as GTS-21) is currently being tested as a possible pharmacological treatment of cognitive dysfunction in Alzheimer's disease. In this study, plasma and brain pharmacokinetics as well as urina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feeee3d104ef96a489341fdfd1325949
https://doi.org/10.1002/(sici)1099-081x(199804)19:3<147::aid-bdd77>3.0.co
https://doi.org/10.1002/(sici)1099-081x(199804)19:3<147::aid-bdd77>3.0.co
Publikováno v:
Drug Development Research. 39:19-28
The synthetic nicotinic agonist GTS-21 and nicotine were compared in aged rats for their ability to enhance cognition and affect the density of brain nicotine receptor subtypes. At 15 min before to daily behavioral testing in the Morris water maze, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b143490e30a7c37dc1a95c00d6df96ec
https://doi.org/10.1002/(sici)1098-2299(19960901)39:1<19::aid-ddr3>3.0.co
https://doi.org/10.1002/(sici)1098-2299(19960901)39:1<19::aid-ddr3>3.0.co
Autor:
I. Zaydenberg, Michael W. Pennington, William R. Kem, Ilya Khaytin, K. Crowley, D.S. Krafte, V.M. Mahnir, M. E. Byrnes
Publikováno v:
Biochemical and Biophysical Research Communications. 219:696-701
Eighteen synthetic analogs of ShK toxin, a thirty-five residue K channel blocker derived from the sea anemone Stichodactyla helianthus, were prepared in order to identify functionally important residues. CD spectra of sixteen of the analogs were virt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8950cf70929191f8371359a6ed57c402
https://doi.org/10.1006/bbrc.1996.0297
https://doi.org/10.1006/bbrc.1996.0297
Autor:
William R. Kem, I. Zaydenberg, M. E. Byrnes, Michael W. Pennington, V.M. Mahnir, Ilya Khaytin
Publikováno v:
Biochemistry. 35:16407-16411
An "Ala scan" analysis of ShK toxin, a 35-residue basic peptide possessing three disulfide bonds, identifies seven side chains which influence binding to brain delayed rectifier potassium channels. Additional analogs were synthesized and tested to fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e632f1f3ff8d65448e196bb31baac3ce
https://doi.org/10.1021/bi962463g
https://doi.org/10.1021/bi962463g
Publikováno v:
Protein & Peptide Letters. 1:239-245
Dendrotoxin, a 59 residue peptide toxin was synthesized using an Fmoc-tBu strategy and folded to the biologically active form . Synthetic dendrotoxin co-eluted with the natural toxin by RP-HPLC, and inhibited [125]-dendrotoxin I binding to rat brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::881420e6d88f89851104e4f187de5de2
https://doi.org/10.2174/0929866501666220517214555
https://doi.org/10.2174/0929866501666220517214555
Autor:
Denise Donaldson, Raymond S. Norton, Kati Kalman, Mark D. Lanigan, William R. Kem, V.M. Mahnir, K. George Chandy, Cheryl T. McVaugh, Michael W. Pennington, David Behm
Publikováno v:
Peptides for the New Millennium ISBN: 0792364457
Michael W. Pennington, Mark Lanigan, Vladimir M. Mahnir, Kati Kalman, Cheryl T. McVaugh, David Behm, Denise Donaldson, K. George Chandy, William R. Kem, and Raymond S. Norton2 Bachem Bioscience Inc., King of Prussia, PA 19406, U.S.A.; Biomolecular Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e315390ff8cbd893dc3c74e9e0e1174
https://doi.org/10.1007/0-306-46881-6_304
https://doi.org/10.1007/0-306-46881-6_304
Autor:
William R. Kem, Susan LeFrancois, Ferenc Soti, Laszlo Prokai, Xuefang Cao, Julia Porter-Papke, Katalin Prokai-Tatrai, Kristin Wildeboer, V.M. Mahnir, Roger L. Papke
Publikováno v:
Molecular pharmacology. 65(1)
3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (DMXBA; GTS-21), an Alzheimer's drug candidate, selectively stimulates alpha7 nicotinic acetylcholine receptors. It rapidly enters the brain after oral administration and enhances cognitive be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6fb84aa8f364c41bdc682968baa9d4
https://pubmed.ncbi.nlm.nih.gov/14722237
https://pubmed.ncbi.nlm.nih.gov/14722237