Zobrazeno 1 - 10
of 78
pro vyhledávání: '"V.G. Casabó"'
Autor:
Ana Belén Ruiz-García, Victor Mangas-Sanjuan, Isabel González-Álvarez, V.G. Casabó, Marival Bermejo, Carlos Fernández-Teruel
Publikováno v:
Xenobiotica. 43:745-754
The objective was to characterize the in vivo absorption and bioavailability (BA) of a low solubility, high permeability fluoroquinolone (CNV97101) that precipitates in the gastrointestinal (GI) tract by mathematical modeling approach. In situ rat in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8c81d020b9e6e655eec860b70d2482
https://doi.org/10.3109/00498254.2012.759667
https://doi.org/10.3109/00498254.2012.759667
Autor:
Marival Bermejo, Magdalena Echezarreta-López, Isabel González-Álvarez, Jorge Gutiérrez-Nieto, Victor Mangas-Sanjuan, Marta González-Álvarez, V.G. Casabó, Mariana Landin
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 41(6)
β-Lapachone (βLAP) is a promising, poorly soluble, antitumoral drug. βLAP combination with cyclodextrins (CDs) improves its solubility and dissolution but there is not enough information about the impact of cyclodextrins on βLAP intestinal permea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591819079bcdf5d37d55b7c679372272
https://pubmed.ncbi.nlm.nih.gov/26602766
https://pubmed.ncbi.nlm.nih.gov/26602766
Publikováno v:
Journal of Pharmaceutical Sciences. 95:1733-1741
Labetalol is a widely used drug for the management of hypertension, which is preferably administered by the oral route despite its low bioavailability. The objective of this study is to ascertain the mechanisms underlying its absorption as an approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c4985bb1c6f1e63f380de63f34b56b
https://doi.org/10.1002/jps.20639
https://doi.org/10.1002/jps.20639
Autor:
A. Martín-Villodre, J.J. Pérez-Ruixo, Elsa López-Pintor, V.G. Casabó, Amparo Nácher, Belén Valenzuela
Publikováno v:
International Journal of Pharmaceutics. 314:21-30
The objective was to develop a semiphysiological population pharmacokinetic model that describes the complex salbutamol sulphate absorption in rat small intestine. In situ techniques were used to characterize the salbutamol sulphate absorption at dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14a6cdc4c96a2e6387f84f0b9091c3f
https://doi.org/10.1016/j.ijpharm.2006.01.019
https://doi.org/10.1016/j.ijpharm.2006.01.019
Autor:
Marival Bermejo, V.G. Casabó, Carlos Fernández-Teruel, I. González-Alvarez, Ana Belén Ruiz-García
Publikováno v:
Journal of Drug Targeting. 13:199-212
The absorption kinetics of sarafloxacin, as a model of fluoroquinolone structure, were studied in the rat small intestine and in Caco-2 cells. The objective of the study was to investigate the mechanistic basis of the drug's intestinal transport in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5db266a731ca64292a04d4e1244e831
https://doi.org/10.1080/10611860500087835
https://doi.org/10.1080/10611860500087835
Autor:
Isabel González-Álvarez, Virginia Merino, Amparo Centelles-Sangüesa, Marta González-Álvarez, Davinia Oltra-Noguera, Marival Bermejo, Victor Mangas-Sanjuan, Ignacio González-García, Gloria Sanchez-Castaño, V.G. Casabó
Publikováno v:
Journal of pharmacological and toxicological methods. 71
Introduction In vitro models with high predictive ability have been revealed as strong tools for pharmaceutical industry. However, the variability in permeability estimations complicates the comparison and combination of data from different laborator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c833670a83313403e1671eb3e2040e
https://pubmed.ncbi.nlm.nih.gov/25433164
https://pubmed.ncbi.nlm.nih.gov/25433164
Publikováno v:
International Journal of Pharmaceutics. 155:109-119
The effect of leucovorin calcium on the intestinal absorption of methotrexate in rat small intestine was investigated using an in situ rat gut technique. First, the kinetic absorption in situ parameters for methotrexate in solution were obtained: V m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2b70343567e86e5ef27fd6998974814
https://doi.org/10.1016/s0378-5173(97)00152-x
https://doi.org/10.1016/s0378-5173(97)00152-x
Publikováno v:
Biopharmaceutics & Drug Disposition. 18:523-532
Amiodarone is a widely used antiarrhythmic agent with highly variable therapeutic effects. These seem to be related, at least in part, to the pharmacokinetics of the drug and particularly to some features of its gastrointestinal absorption process. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d77dcb7edda0406595b6e29cafff700d
https://doi.org/10.1002/(sici)1099-081x(199708)18:6<523::aid-bdd39>3.0.co
https://doi.org/10.1002/(sici)1099-081x(199708)18:6<523::aid-bdd39>3.0.co
Publikováno v:
Journal of Pharmaceutical Sciences. 85:1248-1254
Previous studies showed that the in situ absorption of baclofen in rat jejunum was inhibited by beta-alanine, a nonessential amino acid, and therefore mediated, at least in part, by some beta-amino acid carrier. In this paper a similar study was unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3dbe9ec27749a53921478f558a3d294
https://doi.org/10.1021/js9504346
https://doi.org/10.1021/js9504346
Publikováno v:
International Journal of Pharmaceutics. 132:63-69
Previous studies showed that the absorption of the antispastic drug baclofen, in the rat middle intestine, is inhibited by β-alanine, γ-aminobutyric acid (GABA) and leucine. It was concluded that baclofen intestinal transport was mediated, at least
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19eab1b7fe8b187f1ea942b8e098f3e5
https://doi.org/10.1016/0378-5173(95)04342-x
https://doi.org/10.1016/0378-5173(95)04342-x