Výsledky vyhledávání - "V.A. Chubenko"

Cancer evolution as a new target of treatment paradigm

Autor: V.A. Chubenko

Publikováno v: Practical oncology. 24:33-38

In clinical practice, the cancer treatment is certainly resulted from the biology of tumor growth, the modern understanding of which is based on the theory of genetic changes. In this regard, the effective strategy is the research and target on trigg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe813396b29961fb8f0598316e05c8ae
https://doi.org/10.31917/2401033

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Iron metabolIsm and ferroptosIs as a therapeutIc target

Autor: V.A. Chubenko

Publikováno v: Practical oncology. 23:127-132

The cell death is the most important characteristic of any tissue, including malignant tumors. It controls the proliferation and metastasis. Besides cell death determines the development of the drug resistance. In this context, the understanding of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba790933edab2398df26c3f7f89b51b7
https://doi.org/10.31917/2303127

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The emerging field of checkpoint inhibitors

Autor: V.A. Chubenko

Publikováno v: Practical oncology. 23:93-99

Immunotherapy as a new method allows effective control of the tumor growth. At the same time, the continuous treatment and the novel mechanism of action leads to the possible appearance of the specific immune-mediated adverse events, some of which ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f1a25a36d6a12a9e813682a6d6a9e74
https://doi.org/10.31917/2302093

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Metabolic cancer therapy: proof of concept

Autor: V.A. Chubenko, V.M. Moiseyenko

Publikováno v: Practical oncology. 23:51-61

Today cancer is considered as a genetic disease without taking into account some metabolic features of the cells due to these molecular abnormalities. At the same time, accumulated scientific data indicate that energy homeostasis of the malignant cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e44faa8485cb9e4706da6a83d2917d6a
https://doi.org/10.31917/2301051

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Neoadjuvant anti PD-1 / PD-L1 immune checkpoint inhibitors in locally advanced gastric cancer with microsatellite instability

Autor: A.Y. Navmatulya, V.A. Chubenko, S.A. Savchuk, F.R. Almukhametova, P.Y. Tsuprun, Е.М. Zykov, V.M. Moiseenko, A.I. Kuznetsov, G.S. Inusilaev, V.A. Heinstein, K.V. Shelekhova

Publikováno v: Practical oncology. 22:244-254

Gastric cancer is an aggressive malignant neoplasm of the digestive system. These tumors are genetically heterogeneous,and they could be subdivided into four groups. One of such groups, microsatellite instable (MSI) gastric cancer, is of interest con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff67215362431a584c2779a4ca0db227
https://doi.org/10.31917/2204244

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Therapeutic Targets of Tumor Metabolism

Autor: V.A. Chubenko

Publikováno v: Practical oncology. 22:183-192

Tumor cell metabolism has certain distinctive features such as aerobic glycolysis, utilization of alternative energy sources, increased lipid synthesis, mitochondrial dysfunction, macropinocytosis, autophagy, high levels of ROS, tumor microenvironmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4377eca7aa63afa492fc69faf46c14c2
https://doi.org/10.31917/2203183

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COMBINATIONS OF IMMUNOTHERAPY AND OTHER DRUGS

Autor: V.A. Chubenko

Publikováno v: Practical oncology. 22:33-40

The challenging direction is the combinations of the treatment strategies affecting the various pathogenesis pathways of the malignant neoplasms. In addition to the main mechanism of action (impact on the nucleus or blockade of the cell signalling),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b018a4c51a4bf373e223d88c5191bc99
https://doi.org/10.31917/2201033

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