Výsledky vyhledávání

Toxicity of Doxorubicin on Pig Liver After Chemoembolization with Doxorubicin-loaded Microspheres: A Pilot DNA-microarrays and Histology Study

Autor: Laurence Moine, V. Verret, Alexandre Laurent, Michel Wassef, Julien Namur, Michel Bonneau, Jean-Pierre Pelage, Saida Homayra Ghegediban

Publikováno v: CardioVascular and Interventional Radiology
CardioVascular and Interventional Radiology, Springer Verlag, 2013, 36 (1), pp.204-212. ⟨10.1007/s00270-012-0369-1⟩

International audience; The potential mechanisms accounting for the hepatotoxicity of doxorubicin-loaded microspheres in chemoembolization were examined by combining histology and DNA-microarray techniques. The left hepatic arteries of two pigs were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43e4f1f31dbaf92e99df5d6eb235dc8
https://doi.org/10.1007/s00270-012-0369-1

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Anti-angiogenic drug delivery from hydrophilic resorbable embolization microspheres: an in vitro study with sunitinib and bevacizumab

Autor: Emeline Servais, Stéphanie Louguet, Denis Labarre, Florentina Pascale, V. Verret, Laurence Moine, Laurent Bédouet, Alexandre Laurent, Minh-Tâm Baylatry, Anne Beilvert

Publikováno v: International journal of pharmaceutics. 484(1-2)

Anti-angiogenic (AA) drugs are proposed as novel agents for targeted therapies in hepatocellular carcinoma (HCC). Loading of AA drugs into drug delivery systems for local delivery would reduce their side effects. The present study investigated the lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a5d36ffb8fb64320682cb88d5283b2
https://pubmed.ncbi.nlm.nih.gov/25701631

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Safety and efficacy compared between irinotecan-loaded microspheres HepaSphere and DC bead in a model of VX2 liver metastases in the rabbit

Autor: Atmane Seck, Saida Homayra Ghegediban, Michel Wassef, Angelo Paci, Julien Namur, V. Verret, Alexandre Laurent, Philippe Reb, Florentina Pascale, Keigo Osuga, Manon Sterba, Noboru Maeda

Publikováno v: Journal of vascular and interventional radiology : JVIR. 26(7)

To compare irinotecan-eluting HepaSphere (BioSphere Medical, Roissy-en-France, France) and DC Bead (Biocompatibles UK Ltd, London, United Kingdom) embolization microspheres for distribution in tumors, release properties, tolerance, and antitumor effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc91191e455ebfcf0aa7ddbbde289b4
https://pubmed.ncbi.nlm.nih.gov/25952641

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Targeting and recanalization after embolization with calibrated resorbable microspheres versus hand-cut gelatin sponge particles in a porcine kidney model

Autor: Stéphanie Louguet, Emeline Servais, Keigo Osuga, Michel Wassef, V. Verret, Alexandre Laurent, Laurence Moine, Laurent Bédouet, Noriyuki Tomiyama, Noboru Maeda

Publikováno v: JVIR: Journal of Vascular and Interventional Radiology
JVIR: Journal of Vascular and Interventional Radiology, Elsevier, 2013, 24 (9), pp.1391-1398. ⟨10.1016/j.jvir.2013.05.058⟩

International audience; Purpose: To report on polyethylene glycol hydrogel-based resorbable embolization microspheres (REM) that were synthesized to resorb in < 24 hours, before inflammation and vascular remodeling, to achieve a complete arterial rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b84a41eb1a98019eb3b64245a95aa004
https://pubmed.ncbi.nlm.nih.gov/23891049

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Modified model of VX2 tumor overexpressing vascular endothelial growth factor

Autor: Michel Bonneau, S. Ghegediban, A. Laurent, V. Verret, Florentina Pascale, Michel Wassef, Julien Namur, Laurent Bédouet, Isabelle Schwartz-Cornil

Publikováno v: JVIR: Journal of Vascular and Interventional Radiology
JVIR: Journal of Vascular and Interventional Radiology, Elsevier, 2012, 23 (6), pp.809-817. ⟨10.1016/j.jvir.2012.02.003⟩

International audience; Purpose: To determine whether upregulated expression of vascular endothelial growth factor (VEGF) in VX2 cells can increase vessel density (VD) and reduce tumor necrosis. Materials and Methods: The VX2 cell line was transfecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95ad550c65eed401f8e9b63f18c9ca4
https://pubmed.ncbi.nlm.nih.gov/22498170

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The Arterial Distribution of Embozene and Embosphere Microspheres in Sheep Kidney and Uterus Embolization Models

Autor: V. Verret, Alexandre Laurent, Saida Homayra Ghegediban, Jean Pierre Pelage, Jafar Golzarian, Michel Wassef

Publikováno v: JVIR: Journal of Vascular and Interventional Radiology
JVIR: Journal of Vascular and Interventional Radiology, Elsevier, 2011, 22 (2), pp.220-228. ⟨10.1016/j.jvir.2010.10.021⟩

International audience; Purpose: To compare the in vivo distribution of the new embolic Embozene versus Embosphere as a control in the sheep renal and uterine vasculature. Materials and Methods: Twelve sheep (three per group of product and size) were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3547630181e7630e93a8643e3501be6
https://hal.inrae.fr/hal-02644796

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IL6 and TNF expression in vessels and surrounding tissues after embolization with ibuprofen-loaded beads confirms diffusion of ibuprofen

Autor: Laurent Bédouet, V. Verret, Jean-Pierre Pelage, Michel Wassef, Julien Namur, Andrew L. Lewis, Alexandre Laurent, Claudia Bevilacqua, Isabelle Schwartz-Cornil, Patrice Martin

Publikováno v: European Journal of Pharmaceutical Sciences
European Journal of Pharmaceutical Sciences, Elsevier, 2011, 42 (5), pp.489-495. ⟨10.1016/j.ejps.2011.02.001⟩

Purpose In the treatment of uterine fibroid embolization related pain, the use of embolics loaded with non-steroidal anti-inflammatory drugs (NSAID) relies on an efficient delivery and impregnation of the embolized tissue. Immuno-labelling and spectr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fd2a51dc3193daea2ad690f75cacd6
https://hal.archives-ouvertes.fr/hal-01000487

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