Zobrazeno 1 - 10
of 89
pro vyhledávání: '"V. V. Vlassov"'
Epigenetic «probes» for lung cancer monitoring: LINE-1 methylation pattern in blood- circulating DNA
Autor:
A. A. Ponomaryova, Е. Y. Rykova, N. V. Cherdyntseva, A. A. Bondar, A. Y. Dobrodeev, A. A. Zavyalov, S. A. Tuzikov, L. O. Bryzgalov, T. I. Merkulova, V. V. Vlassov, P. P. Laktionov
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 19, Iss 1, Pp 144-150 (2015)
Malignant cell transformation is accompanied by two processes of DNA methylation changes: promoter hypermethylation of specific genes and hypomethylation of retrotransposons. The composition of circulating DNA (cirDNA) from plasma and cell-surface-bo
Externí odkaz:
https://doaj.org/article/f4b173a92e4c468e9f12fce41c614e52
Publikováno v:
Biogeosciences, Vol 3, Iss 3, Pp 243-249 (2006)
The nonenzymatic template-directed ligation of oligonucleotides containing 2', 3'-cyclic phosphate was investigated in the presence of divalent cations. Ligation of the oligonucleotides readily occurred in the presence of Mg2+, Mn2+, Co2+, Zn2+, Pb2+
Externí odkaz:
https://doaj.org/article/722f3890855e4f79b97b486be2efafcc
Autor:
A A, Ponomaryova, N V, Cherdyntseva, A A, Bondar, A Y, Dobrodeev, A A, Zavyalov, S A, Tuzikov, V V, Vlassov, E L, Choinzonov, P P, Laktionov, E Y, Rykova
Publikováno v:
Molekuliarnaia biologiia. 51(4)
Malignant cell transformation is accompanied with abnormal DNA methylation, such as the hypermethylation of certain gene promoters and hypomethylation of retrotransposons. In particular, the hypomethylation of the human-specific family of LINE-1 retr
Autor:
M. N. Repkova, M. A. Zenkova, E. B. Logashenko, V. V. Vlassov, Alya G. Venyaminova, A. V. Vladimirova, E. L. Chernolovskaya, A. A. Volkov
Publikováno v:
Russian Chemical Bulletin. 55:1275-1283
The ability of chemically modified siRNAs targeted to MDR1 mRNA to inhibit P-glycoprotein expression and to restore sensitivity of cancer cells to antibiotic vinblastine was investigated. The effects of chemical modifications on RNA stability in cell
Publikováno v:
Biology Bulletin. 32:101-107
We studied the binding of antisense oligonucleotides with 23S rRNA of mycobacteria and E. coli and identified oligonucleotides with selective affinity to the α-sarcin loop region of 23S rRNA of M. tuberculosis and to 70S ribosomes of M. smegmatis. T
Autor:
Zh. K. Nazarkina, M. V. Kharkova, D. V. Antonets, E. S. Morozkin, S. I. Bazhan, L. I. Karpenko, V. V. Vlassov, A. A. Ilyichev, P. P. Laktionov
Publikováno v:
Bulletin of Experimental Biology and Medicine. 160:727-727
Autor:
D. Hofmann, J. Engels, I. Demirhan, O. Hasselmayer, A Chandra, Chandra P, V. V. Vlassov, F. P. Svinarchuk
Publikováno v:
Virus Genes. 9:113-119
We have used an in vitro approach to study the efficiency of antisense oligonucleotides in inhibiting LTR-(HIV-1)-directed CAT expression catalyzed by tat protein, the functional protein of the transactivator gene. We selected the target sequence loc
Autor:
V. V. Vlassov
Publikováno v:
Pure and Applied Chemistry. 65:1337-1342
Oligonucleotides and their analogs can form specific complexes with RNA, DNA and various proteins interacting with nucleic acids. Results of in vitro studies evidence that the compounds may affect expression of specific genes and can be considered as
Autor:
E. M. Ivanova, Zarytova Vf, T. V. Abramova, A. G. Pokrovsky, S. R. Chapligina, V. V. Vlassov, Konevets Da, V. P. Starostin, F. P. Svinarchuk, Gorn Vv, V. M. Blinov, L. S. Sandahchiev, O. A. Plyasunova
Publikováno v:
Nucleosides and Nucleotides. 10:419-422
Experiments with the HIV-1 infected MT-4 cells evidence that coupling of lipophilic and alkylating groups to the antisense oligonucleotides improve their anti-HIV efficiency.
Autor:
D. G. Knorre, V. V. Vlassov
Publikováno v:
Genetica. 85:53-63
Development of efficient methods for synthesis of oligonucleotides and oligonucleotide analogs has opened up the possibility of designing a broad spectrum of affinity reagents for specific modification of nucleic acids and proteins. These affinity re