Zobrazeno 1 - 10
of 21
pro vyhledávání: '"V. V. Simonova"'
Autor:
V. V. Simonova, O. O. Smirnova
Publikováno v:
Модернизация, инновация, развитие, Vol 6, Iss 2(22-2), Pp 77-82 (2015)
On June 30, 2015 has come into force the Federal Law of theRussian Federation(№ 488-FL): “On the industrial Policy in theRussian Federation”. The law requires the innovation Production. At the same time, from the whole spectrum of the strategic
Externí odkaz:
https://doaj.org/article/35eb0333a3bb4c04b9f2c0caf01fde83
Publikováno v:
Neuroscience and Behavioral Physiology. 51:704-710
Objective. To assess changes in the time characteristics of the states of sleep and waking which may serve as nonmotor signs of the initial stage of PD using a model of the preclinical stage of Parkinson’s disease (BP) in Wistar rats of different a
Autor:
I. A. Grivennikov, Sergey N. Illarioshkin, S. A. Antonov, E. V. Novosadova, L. E. Frumkina, Leonid G. Khaspekov, K. A. Kutukova, V. V. Simonova, M. V. Ivanov
Publikováno v:
Human Physiology. 46:886-894
Introduction. The study of neuronal differentiation of human induced pluripotent stem cells (iPSCs) offers wide prospects for modeling and analyzing the pathogenesis of human neurodegenerative brain diseases, screening the drugs for efficacious treat
Autor:
T. S. Shemyakova, I. V. Ekimova, V. V. Simonova, S. G. Polonik, Yu. F. Pastukhov, M. A. Guzeev
Publikováno v:
Advances in Gerontology. 10:254-259
Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease that is closely associated with aging. It is considered incurable due to its late diagnosis and the use of symptomatic treatment, which cannot alter the molecular mechanis
Publikováno v:
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 121(4. Vyp. 2)
To develop of a chronic sleep restriction model in rats by repeated sleep deprivation using an orbital shaker and to determine whether this model leads to disturbances in sleep homeostatic mechanisms.Male Wistar rats (7-8 months old) underwent sleep
Publikováno v:
Neuroscience and Behavioral Physiology. 49:580-583
The preoptic area of the hypothalamus (POA) is regarded as an integrative “center” regulating sleep and behavior, though the involvement of chaperones in the molecular mechanisms controlling the sleep–waking cycle and anxiety-like behavior has
Autor:
V. V. Simonova, Yu. F. Pastukhov
Publikováno v:
Journal of Evolutionary Biochemistry and Physiology. 54:494-497
Autor:
V. V. Simonova, Sergey N. Illarioshkin, Leonid G. Khaspekov, A S Vetchinova, E. V. Novosadova
Publikováno v:
Biochemistry (Moscow). 83:1040-1045
The prevalent form of familial parkinsonism is caused by mutations in the LRRK2 gene encoding for the mitochondrial protein kinase. In the review, we discuss possible causes of appearance of tetraploid cells in neuronal precursors obtained from induc
Autor:
Sergey N. Illarioshkin, Vyacheslav Z. Tarantul, Leonid G. Khaspekov, Igor A. Grivennikov, V V Nenasheva, E. S. Manuilova, A S Vetchinova, V. V. Simonova, E. V. Novosadova
Publikováno v:
Bulletin of Experimental Biology and Medicine. 165:378-381
We performed a cytogenetic analysis of the results of CRISPR/Cas9-correction of G2019S mutation in LRRK2 gene associated with Parkinson's disease. Genome editing was performed on induced pluripotent stem cells derived from fibroblasts of a patient ca
Autor:
M. A. Guzeev, I. V. Ekimova, V. V. Simonova, Yu. F. Pastukhov, T. S. Shemyakova, M. V. Chernyshev
Publikováno v:
Journal of Evolutionary Biochemistry and Physiology. 53:431-434