Výsledky vyhledávání - "V. V. Poroikov"

Akademický článek

In Silico Estimation of the Safety of Pharmacologically Active Substances Using Machine Learning Methods: A Review

Autor: V. V. Poroikov, A. V. Dmitriev, D. S. Druzhilovskiy, S. M. Ivanov, A. A. Lagunin, P. V. Pogodin, A. V. Rudik, P. I. Savosina, O. A. Tarasova, D. A. Filimonov

Publikováno v: Безопасность и риск фармакотерапии, Vol 11, Iss 4, Pp 372-389 (2023)

Scientific relevance. Currently, machine learning (ML) methods are widely used in the research and development of new pharmaceuticals. ML methods are particularly important for assessing the safety of pharmacologically active substances early in the

Externí odkaz: https://doaj.org/article/f46683a9d63e48e9aaf0f1cb6b00b44b

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Akademický článek

Chemical named entity recognition in the texts of scientific publications using the naïve Bayes classifier approach

Autor: O. A. Tarasova, A. V. Rudik, N. Yu. Biziukova, D. A. Filimonov, V. V. Poroikov

Publikováno v: Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-12 (2022)

Abstract Motivation Application of chemical named entity recognition (CNER) algorithms allows retrieval of information from texts about chemical compound identifiers and creates associations with physical–chemical properties and biological activiti

Externí odkaz: https://doaj.org/article/86da2f39a6de4e618a8d5f12e47d3a50

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Akademický článek

Current and future use of umifenovir in patients with COVID-19

Autor: Yu. Yu. Kiselev, K. A. Zagorodnikova, D. V. Ivashchenko, A. V. Krykov, I. N. Sychev, A. S. Matveev, K. B. Mirzaev, V. A. Otdelenov, V. M. Tsvetov, A. V. Dmitriev, V. V. Poroikov, D. A. Sychev

Publikováno v: Качественная клиническая практика, Vol 0, Iss 4S, Pp 75-80 (2020)

At the time of print, the evidence for using umifenovir in COVID-19 is mainly theoretical. The published clinical trials have contradicting results. The decision to use umifenovir in COVID-19 should be individualized, considering the “experimental�

Externí odkaz: https://doaj.org/article/086bc563d1bf4e7db1fc4d0bf2b37ae3

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Akademický článek

Rationale for use mefloquine for COVID-19 treatment

Autor: V. A. Otdelenov, K. B. Mirzaev, A. V. Dmitriev, V. V. Poroikov, D. A. Sychev

Publikováno v: Качественная клиническая практика, Vol 0, Iss 4S, Pp 103-105 (2020)

Currently, the use of mefloquine in patients with COVID-19 does not have sufficient scientific justification and, given the unfavorable efficacy and safety profile, cannot be considered for routine use in clinical practice.

Externí odkaz: https://doaj.org/article/20ad4b3385d94174ab13542442c82f92

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Akademický článek

Planning in silico screening and experimental study of the hypoglycemic derivatives of cyclic guanidines

Autor: P. M. Vasiliev, A. A. Spasov, K. V. Lenskaya, V. V. Poroikov, D. A. Filimonov, V. A. Anisimova

Publikováno v: Кубанский научный медицинский вестник, Iss 6, Pp 11-15 (2014)

This article is devoted to the search for new cyclic guanidine derivatives with hypoglycemic activity by means of in silico methods. The results of computer prediction of hypoglycemic effect for nine classes of these compounds were analyzed. Two pers

Externí odkaz: https://doaj.org/article/1fee039c1de94f5381876ec166cf7484

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