Zobrazeno 1 - 10
of 22
pro vyhledávání: '"V. V. Poloskov"'
Autor:
A. N. Narovlyansky, V. V. Poloskov, M. V. Mezentseva, I. A. Suetina, A. V. Tsvetnov, E. Yu. Bogdanov, I. T. Fedyakina, A. L. Kovalenko, F. I. Ershov
Publikováno v:
Медицинская иммунология, Vol 26, Iss 4, Pp 663-670 (2024)
Activation of Toll-like receptors (TLRs) is one of the earliest indicators of functional activation of the innate immune system. Therefore, the development of drugs that stimulate the transcription of TLR/RLR genes and at the same time are “multi-t
Externí odkaz:
https://doaj.org/article/5dc1636eb40f4efea9aa9fc6682a3bea
Autor:
T. M. Sokolova, V. V. Poloskov
Publikováno v:
Биопрепараты: Профилактика, диагностика, лечение, Vol 21, Iss 2, Pp 116-121 (2021)
Kagocel® is used in Russia for the treatment of viral infections. In terms of its chemical structure, Kagocel® active ingredient is a copolymer of gossypol polyphenol and carboxymethylcellulose. The study investigated antiviral and cytokine-inducin
Externí odkaz:
https://doaj.org/article/e2c41820e83e4c2fb626a1a5b5d92fd8
Autor:
A. N. Narovlyansky, V. V. Poloskov, A. M. Ivanova, S. K. Kravchenko, F. E. Babayeva, K. A. Sychevskaya, M. V. Mezentseva, I. A. Suetina, L. I. Russu, A. V. Izmest’eva, T. P. Ospelnikova, A. A. Sarymsakov, F. I. Ershov
Publikováno v:
Вопросы вирусологии, Vol 65, Iss 5, Pp 284-293 (2020)
Introduction. Medicines from the group of interferon inducers (IFNs) “swith on” the synthesis of type 1 interferons (IFN-I) and induce the expression of IFN-stimulated genes (ISGs) that regulate innate immunity reactions and protect the host from
Externí odkaz:
https://doaj.org/article/91fd4eeb0cb24500820c03af366ce693
Autor:
A. N. Narovlyansky, M. V. Mezentseva, I. A. Suetina, L. I. Russu, A. M. Ivanova, V. V. Poloskov, A. V. Izmest'eva, T. P. Ospelnikova, A. A. Sarymsakov, F. I. Ershov
Publikováno v:
Вопросы вирусологии, Vol 64, Iss 4, Pp 165-172 (2019)
Introduction. Cytokines activated in response to immunosuppressive viral infections can directly or indirectly affect the neoplastic transformation of B cells. In this study, we studied a new substance designed to produce the antiviral drug CelAgrip
Externí odkaz:
https://doaj.org/article/5c74045e505044f991c2bdf041dd5fe3
Autor:
V. V. Poloskov, F. I. Ershov
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 1, Pp 188-192 (2019)
The review is dedicated to the description of interferon inducers - new generation drugs created by Russian scientists as a result of the screening of thousands of high- and low-molecular synthetic and natural compounds. The drugs selected for clinic
Externí odkaz:
https://doaj.org/article/4b14e04390e342e4b9ba3096281ed6b5
Autor:
T. M. Sokolova, V. V. Poloskov, A. N. Shuvalov, I. A. Rudneva, T. A. Timofeeva, R. R. Klimova, O. V. Masalova, A. A. Kushch
Publikováno v:
Инфекция и иммунитет, Vol 8, Iss 1, Pp 25-32 (2018)
Macrophages (Mf) play an important role in the pathogenesis of influenza infection, but the obtaining of Mf in large quantities is difficult. In connection with this, in the present study, THP-1 monocytes differentiated by phorbol ether (PMA) into ma
Externí odkaz:
https://doaj.org/article/01c5f97902f84a85bf93d1915bbdffa2
Publikováno v:
Медицинская иммунология, Vol 19, Iss 6, Pp 721-730 (2017)
In vitro differentiation of donor blood monocytes to macrophages (Mph) following GM-CSF treatment was accompanied by a significant increase in the levels of gene transcription signaling receptors TLR7 or RIG1. The levels of intracellular viral RNA (M
Externí odkaz:
https://doaj.org/article/0025d1b595334a7f9b64bd68e144ae96
Publikováno v:
Медицинская иммунология, Vol 19, Iss 1, Pp 27-34 (2017)
The levels of TLR/RLR gene expression and production of some cytokines were studied in monocytic THP-1 cell line during its differentiation to mature macrophage-like forms induced by phorbol 12-myristate 13-acetate (PMA) treatment for 1 and 5 days in
Externí odkaz:
https://doaj.org/article/6ad216fcd0e5447faba9111fad76b351
Publikováno v:
Вопросы вирусологии, Vol 61, Iss 1, Pp 21-26 (2016)
The innate immune receptors TLR4, TLR7, TLR8, and RIG1 recognized the structures of the influenza viruses in human lymphocytes and were activated by the recombinant avian influenza virus A/Vietnam/1203/04 and its escape-mutant m13(13) during early pe
Externí odkaz:
https://doaj.org/article/11efbf85367743eba0018ee42715d696
Autor:
V V Poloskov, T P Ospelnikova, I. A. Suetina, A A Sarymsakov, M. V. Mezentseva, L. I. Russu, A. N. Narovlyansky, A M Ivanova, A V Izmest'eva, Ershov Fi
Publikováno v:
Problems of Virology. 64:165-172
Introduction . Cytokines activated in response to immunosuppressive viral infections can directly or indirectly affect the neoplastic transformation of B cells. In this study, we studied a new substance designed to produce the antiviral drug CelAgrip