Zobrazeno 1 - 10 of 23 pro vyhledávání: '"V. V. Lylo"'
1
The primary culture of malignant glioma cells as a model for the study of anti-tumor activity of substances
Autor: O. Y. Glavatskyi, I. M. Shuba, O. I. Kornelyuk, V. V. Lylo, I. S. Karpova
Publikováno v: Visnik ukrains'kogo tovaristva genetikiv i selekcioneriv. 17:196-203
Aim. The aim of our work was to optimize the scheme of obtaining primary cell culture of malignant gliomas, which can be a model for a personalized approach in the selection of chemotherapeutic exposure tactics. Methods. The standard glioma cell line
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4158721bdd39d6a2da81e909b0712165
https://doi.org/10.7124/visnyk.utgis.17.2.1221
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2
Noncanonical DNA-binding properties of potential components of an antitumor composition (cytokine AIMP1/p43, lectin SNA, izatizon), which are able to affect different targets
Autor: O. V. Starozhuk, L. G. Palchykovska, O. Yu. Tsuvariev, T. V. Shyrina, V. V. Lylo, I.S. Karpova, L. A. Zayika, O. I. Kornelyuk
Publikováno v: Faktori eksperimental'noi evolucii organizmiv. 22:323-328
Aim. To search the DNA-binding properties of various drugs promising for the creation of the antitumor composition (AIMP1/p43, SNA-I, izatizon), as well as their ability to influence on key matrix processes – DNA transcription and replication, whic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82e9999535f62f63f5cf920b40e0b978
https://doi.org/10.7124/feeo.v22.969
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3
LECTINS OF SAMBUCUS NIGRA AS BIOLOGICALLY ACTIVE AND DNA-PROTECTIVE SUBSTANCES
Autor: V. V. Lylo, K. V. Kotsarenko, L. L. Macewicz, I.S. Karpova, T.O. Ruban, L. L. Lukash, L. G. Palchykovska
Publikováno v: Acta Horticulturae. :93-102
The human genome is affected by diverse environmental pollution factors and this is particularly acute for Ukrainians who have suffered from the Chernobyl radiation disaster. At the same time many natural compounds, especially from medicinal plants,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14caed98ae3bca7d38e6b9ca4049d68e
https://doi.org/10.17660/actahortic.2015.1061.9
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5
Correlation of mutagenesis level with expression of reparative enzyme O6-methylguanine DNA methyltransferase during establishment of cell lines in vitro
Autor: L. L. Macewicz, G. R. Akopyan, K. V. Kotsarenko, V. O. Kushniruk, N. L. Huleuk, V. V. Lylo, L. L. Lukash, A. P. Iatsyshyna, D. O. Mykytenko
Publikováno v: Biopolymers and Cell, Vol 29, Iss 6, Pp 480-486 (2014)
Long-term cultivation of cell lines inevitably leads to genetic and epigenetic changes. The aim of this work was a comparative analysis of karyotype and level of the expression of reparative enzyme O6-methylguanine-DNA- methyltransferase (MGMT) at di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5050966412259d4d6fc42a7a00914a8b
https://doi.org/10.7124/bc.00083d
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6
Change in the MGMT gene expression under the influence of exogenous cytokines in human cells in vitro
Autor: V. V. Lylo, K. V. Kotsarenko, T. A. Ruban, A. I. Kornelyuk, L. L. Macewicz, L. A. Babenko, L. L. Lukash
Publikováno v: Cytology and Genetics. 47:202-209
The influence of cytokines LIF, SCF, IL-3, and EMAP II and the Laferobion (IFN-a2b) drug on the MGMT gene expression in human cell cultures has been studied. It was shown that exogenous cytokines can modulate the MGMT gene expression at the protein l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33891de15f8b53c779e4f97e167e9ba2
https://doi.org/10.3103/s0095452713040087
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7
Activation of gene expression of the O6-methylguanine-DNA-transferase repair enzyme upon the influence of EMAP II cytokine in human cells in vitro
Autor: E. V. Kotsarenko, Matsevich Ll, L. A. Babenko, A. I. Kornelyuk, V. V. Lylo, L. L. Lukash, Sukhorada Em
Publikováno v: Cytology and Genetics. 45:373-378
The aim of the study is to evaluate the effect of recombinant EMAP II cytokine (endothelial and monocyte-activating polypeptide II) on the level of MGMT gene expression; this gene encodes the O6-methylguanine-DNA-methyltransferase (MGMT) repair enzym
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa3570e628bffde410c78f68679f7e48
https://doi.org/10.3103/s0095452711060053
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9
Influence of EMAP II, IFN-α2b and its medicinal preparations on the MGMT protein amount in human cells in vitro
Autor: L. L. Macewicz, A. I. Kornelyuk, V. V. Lylo, K. V. Kotsarenko, S. I. Chernykh, L. L. Lukash, T. P. Ruban
Publikováno v: Biopolymers and Cell, Vol 30, Iss 6, Pp 448-453 (2014)
Aim. To study the effect of EMAP II, IFN-α2b and its medicinal preparations on the amount of O6-methylguanine-DNA methyltransferase (MGMT) protein in human cells in vitro. Methods. The human cells of 4BL and Hep-2 lines were treated with the purifie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6745bed8588eeed298a485def32bab
http://dspace.nbuv.gov.ua/handle/123456789/154591
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