Výsledky vyhledávání - "V. V. Liakhovich"

Akademický článek

EXPRESSION OF mRNA FOR CYTOKINES COMPARED TO THEIR CONCENTRATIONS IN CULTURE SUPERNATES OF U937 CELLS EXPOSED TO POLYCLONAL ACTIVATORS

Autor: A. I. Autenshlyus, I. D. Ivanov, A. V. Golovanova, A. A. Studenikina, E. S. Mikhaylova, V. A. Vavilin, N. A. Varaksin, V. V. Liakhovich

Publikováno v: Медицинская иммунология, Vol 21, Iss 4, Pp 737-742 (2019)

Investigation of the cytokine expression dynamics as well as the cytokine-producing potential of immune-competent cells allows extensive studies of their functional characteristics. mRNAs encoding a number of cytokine genes are relatively stable, thu

Externí odkaz: https://doaj.org/article/3d01828cf00e45e583b1c6cd0cf19644

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[Cholesterol lowering properties of a complex compound simvastatin with glycyrrhizic acid (simvaglyzin) in experimental models]

Autor: V A, Vavilin, N F, Salakhutdinov, Iu I, Ragino, N E, Poliakov, M B, Taraban, T V, Leshina, E M, Stakhneva, V V, Liakhovich, Iu P, Nikitin, G A, Tolstikov

Publikováno v: Biomeditsinskaia khimiia. 54(3)

A molecular complex of simvastatin (SV) and glycyrrhyzic acid (GA) (at the ratio of 1 : 4), has been synthesized. The complex named "simvaglyzin" (SVG) was stable in aqeous and aqua-alcohol solutions at GA concentrations exceeding 0.2 mM. In vitro SV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5a591736560af8640a1e3263a603a28
https://pubmed.ncbi.nlm.nih.gov/18712086

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[Real-time polymerase chain reaction and its potential clinical application]

Autor: M Iu, Shamanina, V A, Vavilin, V A, Mordvinov, A V, Katokhin, T N, Kuznetsova, V V, Liakhovich

Publikováno v: Vestnik Rossiiskoi akademii meditsinskikh nauk. (7)

The review introduces real-time polymerase technique, a modern high-tech method, to the medical community. Physico-chemical principles of the method, its main stages, and variants of techniques applying fluorescent reporter platforms are considered.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::154c0df09d162f6ff3685e15f3e9740d
https://pubmed.ncbi.nlm.nih.gov/17718077

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[Restriction analysis of N-acetyltransferase 2 gene in Caucasian population of West Siberia]

Autor: M V, Nikishina, S I, Makarova, A G, Akishev, V A, Vavilin, S Kh, Degtiarev, V V, Liakhovich

Publikováno v: Genetika. 40(11)

Restriction analysis of the NAT2 gene was carried out in inhabitants of Novosibirsk. Polymorphism of this gene for nine known point mutations was studied in a sample of Novosibirsk residents consisting of 109 healthy Caucasians. The frequencies of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::086c984b28e62067e9a8dfe179e31cb3
https://pubmed.ncbi.nlm.nih.gov/15612575

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[Use of restriction endonucleases Bst2U I and Acc65 I to detect Kpn I polymorphism of NAT2 gene]

Autor: M V, Nikishina, A G, Akishev, S I, Makarova, V A, Vavilin, S Kh, Degtiarev, V V, Liakhovich

Publikováno v: Biomeditsinskaia khimiia. 50(3)

RFLP-analysis was made for 30 human DNA samples. The ability of application of restriction endonucleases Acc65I and Bst2UI to find point mutation C481T in NAT2 gene has been demonstrated for the first time. Variants of these enzymes application are d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af53cab298026c5f9b55d8befb6a7c08
https://pubmed.ncbi.nlm.nih.gov/15354537

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[mRNA level and cytochrome P450 1A activity in the liver of C57BL mice induced by various xenobiotics]

Autor: O N, Mikhaĭlova, M L, Filipenko, O A, Timofeeva, V I, Kaledin, L F, Guliaeva, V V, Liakhovich

Publikováno v: Biomeditsinskaia khimiia. 49(4)

The rate of hepatic cytochrome P450 Cypla1 and Cyp1a2 induction was investigated in C57BL male mice during induction with o-aminoazotoluene (OAT), benzo[a]pyrene (BP) and 1,4-dihydroxyanthraquinone (AQ). The Cypla1 mPNA level determined by quantitati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94b7d6a14875788ff5b783efbee140a8
https://pubmed.ncbi.nlm.nih.gov/14562683

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[Polymorphic genes of xenobiotic-metabolizing enzymes associated with bronchial asthma in genetically predisposed children]

Autor: V A, Vavilin, S I, Makarova, V V, Liakhovich, S M, Gavalov

Publikováno v: Genetika. 38(4)

The frequencies of the CYP1A1 valine allele, homozygous deletions of GSTM1 and GSTT1, and two point mutations of the NAT2 gene, (C481--T) and S2 (G590--A), were compared in healthy children and children having bronchial asthma. The S1 mutation was as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbb7cc79d71002cbe00216c3dbaaea29
https://pubmed.ncbi.nlm.nih.gov/12018173

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[Role of xenobiotic biotransformation enzymes in susceptibility to bronchial asthma and in formation of its clinical phenotypic features]

Autor: V V, Liakhovich, V A, Vavilin, S I, Makarova, S M, Gavalov, O A, Riabova, O B, Chasovnikova, N I, Gutkina

Publikováno v: Vestnik Rossiiskoi akademii meditsinskikh nauk. (12)

The paper shows the impact of some mutations of CYP1A, GSTM1, GSTT1, and NAT2 genes and different combinations of alleles of these genes on susceptibility to bronchial asthma and its clinical features. Passive smoking modulates these relationships.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d02a50a288cf99a2abcd1c316282826
https://pubmed.ncbi.nlm.nih.gov/11202642

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[Genetic polymorphism in glutathione S-transferase M1 and T1 in children with bronchial asthma]

Autor: V A, Vavilin, O B, Chasovnikova, V V, Liakhovich, S M, Gavalov, O A, Riabova

Publikováno v: Voprosy meditsinskoi khimii. 46(4)

Asthmatic (n = 100) and health (n = 104) children were compared for rates of homozygous deletions of the glutathione S-transferase class mu and theta genes (null genotypes, GSTM1"-" and GSTT1"-", respectively). The frequency of GSTM1"-" and GSTT1"-"

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcbe958388fac47b9e9239aa58cc4b77
https://pubmed.ncbi.nlm.nih.gov/11075422

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