Zobrazeno 1 - 10
of 252
pro vyhledávání: '"V. Tzingounis"'
Autor:
J. Soto-Perez, C. M. Cleary, C. R. Sobrinho, S. B. Mulkey, J. L. Carroll, A. V. Tzingounis, D. K. Mulkey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Loss- and gain-of-function variants in the gene encoding KCNQ2 channels are a common cause of developmental and epileptic encephalopathy, a condition characterized by seizures, developmental delays, breathing problems, and early mortality. T
Externí odkaz:
https://doaj.org/article/d561153d7af04b878cae1cdf1c996f51
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Over the last decade KCNQ2 channels have arisen as fundamental and indispensable regulators of neonatal brain excitability, with KCNQ2 loss-of-function pathogenic variants being increasingly identified in patients with developmental and epileptic enc
Externí odkaz:
https://doaj.org/article/469ed0e936e6469dacc7c7107b5679b1
Autor:
Xiaojie Gao, Franziska Bender, Heun Soh, Changwan Chen, Mahsa Altafi, Sebastian Schütze, Matthias Heidenreich, Maria Gorbati, Mihaela-Anca Corbu, Marta Carus-Cadavieco, Tatiana Korotkova, Anastasios V. Tzingounis, Thomas J. Jentsch, Alexey Ponomarenko
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Hippocampal pyramidal cells encode an animal’s location by single action potentials and complex spike bursts. The authors show that Kcnq3-containing M-channels synergistically with GABAergic inputs coordinate complex spike bursts during theta oscil
Externí odkaz:
https://doaj.org/article/f33b14e1f0f7463ca569e8ee7b4956bb
Autor:
Linda L. Boshans, Heun Soh, William M. Wood, Timothy M. Nolan, Ion I. Mandoiu, Yuchio Yanagawa, Anastasios V. Tzingounis, Akiko Nishiyama
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Oligodendrocyte precursor cells (NG2 glia) are uniformly distributed proliferative cells in the mammalian central nervous system and generate myelinating oligodendrocytes throughout life. A subpopulation of OPCs in the neocortex arises from
Externí odkaz:
https://doaj.org/article/c376f891da9845b0a6362b73b6570587
Autor:
Danielle M. Caefer, Nhat Q. Phan, Jennifer C. Liddle, Jeremy L. Balsbaugh, Joseph P. O’Shea, Anastasios V. Tzingounis, Daniel Schwartz
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Okur-Chung Neurodevelopmental Syndrome (OCNDS) is caused by heterozygous mutations to the CSNK2A1 gene, which encodes the alpha subunit of protein kinase CK2. The most frequently occurring mutation is lysine 198 to arginine (K198R). To investigate th
Externí odkaz:
https://doaj.org/article/48a3629b5e9c48248660445d518f72c2
Publikováno v:
Advances in Physiology Education. 46:693-702
Since its discovery in the mid-20th century, the Hodgkin-Huxley biophysical model of the squid giant axon's (SGA's) neurophysiology has traditionally served as the basis for the teaching of action potential (AP) dynamics in the physiology classroom.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d52e8583a63b04f461406da61a362c
https://doi.org/10.1152/advan.00171.2021
https://doi.org/10.1152/advan.00171.2021
Autor:
Shaun S Sanders, Luiselys M Hernandez, Heun Soh, Santi Karnam, Randall S Walikonis, Anastasios V Tzingounis, Gareth M Thomas
Publikováno v:
eLife, Vol 9 (2020)
The palmitoyl acyltransferase (PAT) ZDHHC14 is highly expressed in the hippocampus and is the only PAT predicted to bind Type-I PDZ domain-containing proteins. However, ZDHHC14’s neuronal roles are unknown. Here, we identify the PDZ domain-containi
Externí odkaz:
https://doaj.org/article/3bf2d48f0eda4e9999d27548f27e9678
Publikováno v:
Biophysical Journal. 121:3334-3344
Recent work has established that axons have a periodic skeleton structure comprising of azimuthal actin rings connected via longitudinal spectrin tetramer filaments. This structure endows the axon with structural integrity and mechanical stability. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60de025cebe64762cdd26351d217906e
https://doi.org/10.1016/j.bpj.2022.08.027
https://doi.org/10.1016/j.bpj.2022.08.027
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1007003 (2019)
The axon plasma membrane consists of the membrane skeleton, which comprises ring-like actin filaments connected to each other by spectrin tetramers, and the lipid bilayer, which is tethered to the skeleton via, at least, ankyrin. Currently it is unkn
Externí odkaz:
https://doaj.org/article/51dbc9105d174deaba968c6a55c7f829
Publikováno v:
Function. 4
Small-conductance calcium-activated potassium (SK) channels show a ubiquitous distribution on neurons, in both somatodendritic and axonal regions. SK channels are associated with neuronal activity regulating action potential frequency, dendritic exci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63392e3f175fbcf17529e2d73ad63de2
https://doi.org/10.1093/function/zqad018
https://doi.org/10.1093/function/zqad018