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AB0263 THE LEVEL OF 7-HYDROXY METHOTREXATE IN BLOOD CELLS IN PATIENTS WITH RHEUMATOID ARTHRITIS DIRECTLY CORRELATES WITH THE LEVEL OF POLYGLUTAMATES OF METHOTREXATE

Autor: G. Gridneva, Y. Muraviev, Anna V. Kudryavtseva, N. Baymeeva, E. Samarkina, Svetlana Glukhova, V. Sygyrta, E. Aronova

Publikováno v: Annals of the Rheumatic Diseases. 80:1158.1-1158

Background:7-hydroxy Methotrexate (7-hydroxy-MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases. It is known that 7-hydroxy MTX can reduce the effectiveness of methotrexate, which is associated with increased excreti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a8cbf75a918698ace07fd3fd356304e
https://doi.org/10.1136/annrheumdis-2021-eular.2276

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AB0225 TUMOR NECROSIS FACTOR ALPHA (TNF-Α) INHIBITORS IN PATIENTS WITH REFRACTORY RHEUMATOID ARTHRITIS: REASONS FOR WITHDRAWAL

Autor: Svetlana Glukhova, V. Sygyrta, E. Aronova, Alexander Lila

Publikováno v: Annals of the Rheumatic Diseases. 80:1138.2-1139

Background:Refractory rheumatoid arthritis (RRA) is a subtype of rheumatoid arthritis (RA), in which the sequential administration of optimal methotrexate doses in combination with glucocorticoids, and at least - two biologic disease-modifying antirh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a074e9f993e9cd02dd3467e388f8563d
https://doi.org/10.1136/annrheumdis-2021-eular.2347

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POS0467 STUDY OF METHOTREXATE METABOLITES CONCENTRATIONS IN RED BLOOD CELLS AND MONONUCLEAR CELLS IN RHEUMATOID ARTHRITIS

Autor: Anna V. Kudryavtseva, Alexander Lila, G. Gridneva, V. Sygyrta, Y. Muraviev, E. Samarkina, N. Baymeeva, E. Aronova

Publikováno v: Annals of the Rheumatic Diseases. 80:465.2-465

Background:Studying the dynamics of the methotrexate metabolites concentration in cells will help to predict the therapeutic effect and assess patient compliance. We suggest that studying the dynamics of changes in the concentration of methotrexate m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19c7988f98184a3e08132a03f8ae959e
https://doi.org/10.1136/annrheumdis-2021-eular.2351

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AB0324 REASONS FOR DISCONTINUATION OF BIOLOGICS IN PATIENTS WITH REFRACTORY RHEUMATOID ARTHRITIS: RESULTS OF A RETROSPECTIVE STUDY

Autor: V. Sygyrta, Alexander Lila, E. Aronova, A. Satybaldyev, Svetlana Glukhova

Publikováno v: Annals of the Rheumatic Diseases. 79:1461.1-1461

Background:Refractory rheumatoid arthritis (RRA) is a subtype of rheumatoid arthritis (RA), in which the sequential administration of optimal methotrexate (MT) doses in combination with glucocorticoids (GCs), and at least - two biologic disease-modif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd103f677d1d58cce0373264b2f5cd07
https://doi.org/10.1136/annrheumdis-2020-eular.2735

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