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Relatório de Estágio Marques de Almeida, J. Nunes, V. Simões & Associados, SROC SA

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

O presente relatório tem por base um estágio curricular no âmbito do Mestrado em Auditoria Empresarial e Pública, lecionado no Instituto Superior de Contabilidade e Administração de Coimbra, tendo como principal objetivo demonstrar as tarefas d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ce6f9ff2f482eb1e44c2c81f1b2ca3a4

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Akademický článek

Autor: Jezid Miranda, Cristina Paules, Guillaume Noell, Lina Youssef, Angel Paternina-Caicedo, Francesca Crovetto, Nicolau Cañellas, María L. Garcia-Martín, Nuria Amigó, Elisenda Eixarch, Rosa Faner, Francesc Figueras, Rui V. Simões, Fàtima Crispi, Eduard Gratacós

Publikováno v: iScience, Vol 26, Iss 9, Pp 107620- (2023)

Summary: Fetal growth restriction (FGR) affects 5–10% of pregnancies, is the largest contributor to fetal death, and can have long-term consequences for the child. Implementation of a standard clinical classification system is hampered by the multi

Externí odkaz: https://doaj.org/article/1a7c831b8a3241cbb60c4ad445964704

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Relatório de estágio Marques de Almeida, J. Nunes, V. Simões & Associados, SROC, S. A. na área da auditoria

Autor: Dinis, Sílvia Cristina Pereira

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

Este relatório tem como objetivo descrever as tarefas desempenhadas durante o estágio na delegação de Coimbra da empresa Marques de Almeida, J.Nunes, V.Simões & Associados - SROC, S.A., que decorreu de 04 de janeiro até 30 de junho de 2016, faz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::dd31ac19a9c75cc36841d1baad05dc07

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Akademický článek

Designing optimized drug candidates with Generative Adversarial Network

Autor: Maryam Abbasi, Beatriz P. Santos, Tiago C. Pereira, Raul Sofia, Nelson R. C. Monteiro, Carlos J. V. Simões, Rui Brito, Bernardete Ribeiro, José L. Oliveira, Joel P. Arrais

Publikováno v: Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-16 (2022)

Abstract Drug design is an important area of study for pharmaceutical businesses. However, low efficacy, off-target delivery, time consumption, and high cost are challenges and can create barriers that impact this process. Deep Learning models are em

Externí odkaz: https://doaj.org/article/7198e0181ce94996b3f69a3a3350a466

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Akademický článek

Explainable deep drug–target representations for binding affinity prediction

Autor: Nelson R. C. Monteiro, Carlos J. V. Simões, Henrique V. Ávila, Maryam Abbasi, José L. Oliveira, Joel P. Arrais

Publikováno v: BMC Bioinformatics, Vol 23, Iss 1, Pp 1-24 (2022)

Abstract Background Several computational advances have been achieved in the drug discovery field, promoting the identification of novel drug–target interactions and new leads. However, most of these methodologies have been overlooking the importan

Externí odkaz: https://doaj.org/article/ce862bbbb14f4e208b0489dee1f9f22c

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Akademický článek

Design of a multifaceted strategy based on automated text messaging in patients with recent heart failure admission

Publikováno v: ESC Heart Failure, Vol 8, Iss 6, Pp 5523-5530 (2021)

Abstract Aims To evaluate a telemonitoring strategy based on automated text messaging and telephone support after heart failure (HF) hospitalization. Methods and results The MESSAGE‐HF study is a prospective multicentre, randomized, nationwide tria

Externí odkaz: https://doaj.org/article/7699de9d20574ab98344e8c5b9672896

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Akademický článek

Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction

Autor: Lina Youssef, Rui V. Simões, Jezid Miranda, María Luisa García-Martín, Cristina Paules, Francesca Crovetto, Nuria Amigó, Nicolau Cañellas, Eduard Gratacos, Fatima Crispi

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Preeclampsia (PE) and fetal growth restriction (FGR) are both placenta-mediated disorders with unclear pathogenesis. Metabolomics of maternal and fetal pairs might help in understanding these disorders. We recruited prospectively pregnancies

Externí odkaz: https://doaj.org/article/d6aaaf41e16a4bf398e8f7ed65b26696

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Akademický článek

Glucose fluxes in glycolytic and oxidative pathways detected in vivo by deuterium magnetic resonance spectroscopy reflect proliferation in mouse glioblastoma

Autor: Rui V. Simões, Rafael N. Henriques, Beatriz M. Cardoso, Francisca F. Fernandes, Tânia Carvalho, Noam Shemesh

Publikováno v: NeuroImage: Clinical, Vol 33, Iss , Pp 102932- (2022)

Objectives: Glioblastoma multiforme (GBM), the most aggressive glial brain tumors, can metabolize glucose through glycolysis and mitochondrial oxidation pathways. While specific dependencies on those pathways are increasingly associated with treatmen

Externí odkaz: https://doaj.org/article/78bb5da2923449b69fc4b21d11b78909

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