Poly I:C elicits broader and stronger humoral and cellular responses to a Plasmodium vivax circumsporozoite protein malaria vaccine than Alhydrogel in mice

Autor: Tiffany B. L. Costa-Gouvea, Katia S. Françoso, Rodolfo F. Marques, Alba Marina Gimenez, Ana C. M. Faria, Leonardo M. Cariste, Mariana R. Dominguez, José Ronnie C. Vasconcelos, Helder I. Nakaya, Eduardo L. V. Silveira, Irene S. Soares

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Malaria remains a global health challenge, necessitating the development of effective vaccines. The RTS,S vaccination prevents Plasmodium falciparum (Pf) malaria but is ineffective against Plasmodium vivax (Pv) disease. Herein, we evaluated the murin

Externí odkaz: https://doaj.org/article/3a2085bd9a8649d9b5558600265539c9

ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores

Autor: Milena S. Marcolino, MD, MSc, PhD, Magda C. Pires, PhD, Lucas Emanuel F. Ramos, Rafael T. Silva, Luana M. Oliveira, MSc, Rafael L.R. Carvalho, PhD, Rodolfo Lucas S. Mourato, Adrián Sánchez-Montalvá, MD, PhD, Berta Raventós, MSc, Fernando Anschau, MD, PhD, José Miguel Chatkin, MD, PhD, Matheus C.A. Nogueira, MD, Milton H. Guimarães-Júnior, MD, MSc, Giovanna G. Vietta, MD, PhD, Helena Duani, MD, PhD, Daniela Ponce, MD, PhD, Patricia K. Ziegelmann, PhD, Luís C. Castro, PhD, Karen B. Ruschel, PhD, Christiane C.R. Cimini, MD, MSc, Saionara C. Francisco, MSc, Maiara A. Floriani, MSc, Guilherme F. Nascimento, MSc, Bárbara L. Farace, MD, Luanna S. Monteiro, MD, Maira V.R. Souza-Silva, MD, Thais L.S. Sales, MSc, Karina Paula M.P. Martins, MD, MSc, Israel J. Borges do Nascimento, Tatiani O. Fereguetti, MD, Daniel T.M.O. Ferrara, Fernando A. Botoni, MD, Ana Paula B.S. Etges, PhD, Alexandre V. Schwarzbold, MD, PhD, Amanda O. Maurílio, MD, Ana Luiza B.A. Scotton, MD, André P. Weber, André S.M. Costa, MD, Andressa B. Glaeser, Angélica Aparecida C. Madureira, MD, Angelinda R. Bhering, MD, Bruno Mateus de Castro, Carla Thais C.A. da Silva, Carolina M. Ramos, MD, Caroline D. Gomes, Cíntia A. de Carvalho, Daniel V. Silveira, MD, MSc, Edilson Cezar, Elayne C. Pereira, PhD, Emanuele Marianne S. Kroger, MD, Felipe B. Vallt, Fernanda B. Lucas, MD, Fernando G. Aranha, MD, Frederico Bartolazzi, MD, MSc, Gabriela P. Crestani, Gisele A.N. Bastos, MD, ScD, Glícia Cristina de C. Madeira, MD, Helena Carolina Noal, MSc, Heloisa R. Vianna, MD, MSc, Henrique C. Guimarães, MD, PhD, Isabela M. Gomes, Israel Molina, MD, PhD, Joanna d'Arc L. Batista, MD, PhD, Joice C. de Alvarenga, MD, Júlia D.S.S. Guimarães, MD, Júlia D.P. de Morais, MD, Juliana M. Rugolo, Karen Cristina J.R. Pontes, Kauane Aline M. dos Santos, Leonardo S. de Oliveira, Lílian S. Pinheiro, Liliane S. Pacheco, MD, MSc, Lucas de D. Sousa, MD, Luciana S.F. Couto, Luciane Kopittke, PhD, Luis Cesar S. de Moura, PhD, Luisa Elem A. Santos, Máderson A.S. Cabral, MD, Maíra D. Souza, MD, Marcela G.T. Tofani, MD, Marcelo Carneiro, MD, PhD, Maria Angélica P. Ferreira, PhD, Maria Aparecida C. Bicalho, MD, PhD, Maria Clara P.B. Lima, Mariana F. Godoy, MD, Marilia M.A. Cardoso, PhD, Meire P. Figueiredo, Natália C.S. Sampaio, Natália L. Rangel, MD, Natália T. Crespo, MD, Neimy R. de Oliveira, MD, Pedro L. Assaf, MD, Petrônio José de L. Martelli, MD, PhD, Rafaela S.C. Almeida, Raphael C. Martins, Raquel Lutkmeier, Reginaldo Aparecido Valacio, Renan G. Finger, MD, Ricardo B. Cardoso, MSc, Roberta Pozza, MD, PhD, Roberta X. Campos, MD, Rochele M. Menezes, MD, Roger M. de Abreu, MD, Rufino de F. Silva, MD, Silvana M.M. Guimarães, MD, Silvia F. Araújo, MD, Susany Anastácia Pereira, Talita F. Oliveira, MD, Tatiana Kurtz, MD, PhD, Thainara C. de Oliveira, Thaíza Simônia M.A. Araújo, Thulio Henrique O. Diniz, MD, Veridiana B. dos Santos, Virginia Mara R. Gomes, Vitor Augusto L. do Vale, Yuri C. Ramires, MD, Eric Boersma, MD, PhD, Carisi A. Polanczyk, MD, PhD

Publikováno v: International Journal of Infectious Diseases, Vol 110, Iss , Pp 281-308 (2021)

Objectives: The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admissi

Externí odkaz: https://doaj.org/article/72d2ab38013b4648b8a55f0904cc1d7a

Antibodies Against the Plasmodium vivax Apical Membrane Antigen 1 From the Belem Strain Share Common Epitopes Among Other Worldwide Variants

Autor: Ana Caroline Barbosa França, Kátia Sanches Françoso, Rodolfo Ferreira Marques, Gustavo H. G. Trossini, Renan A. Gomes, Marinete M. Póvoa, Maristela G. Cunha, Eduardo L. V. Silveira, Irene S. Soares

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

Malaria is a human parasitic disease distributed in many tropical countries and caused by various Plasmodium species. Plasmodium vivax has the largest geographical distribution of the Plasmodium species and is predominant in the Americas, including B

Externí odkaz: https://doaj.org/article/88b258c5464845de9d2f43aeadbc40d1

Flavivirus-Mediating B Cell Differentiation Into Antibody-Secreting Cells in Humans Is Associated With the Activation of the Tryptophan Metabolism

Autor: Vivian Bonezi, Allan H. D. Cataneo, Maryana S. F. Branquinho, Maysa B. B. Silva, Patricia Gonzalez-Dias, Samuel S. Pereira, Luís C. de Souza Ferreira, Helder I. Nakaya, Ana Campa, Pryscilla F. Wowk, Eduardo L. V. Silveira

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Patients infected with the Dengue virus (DENV) often present with a massive generation of DENV-specific antibody-secreting cells (ASCs) in the blood. In some cases, these ASCs represent more than 50% of the circulating B cells, a higher magnitude tha

Externí odkaz: https://doaj.org/article/df61bf3672ec409eb8ab728ef2a32bf5

Selection and Prioritization of Software Requirements Applying Verbal Decision Analysis

Autor: Paulo A. M. Barbosa, Plácido R. Pinheiro, Francisca R. V. Silveira, Marum Simão Filho

Publikováno v: Complexity, Vol 2019 (2019)

During the software development process, the decision maker (DM) must master many variables inherent in this process. Software releases represent the order in which a set of requirements is implemented and delivered to the customer. Structuring and e

Externí odkaz: https://doaj.org/article/f41839eebc70422dbebce5611ff00605