Zobrazeno 1 - 10
of 512
pro vyhledávání: '"V. Schaefer"'
Autor:
Laura V Schaefer, Silas Dech, Friederike Carnarius, Florian Rönnert, Frank N Bittmann, Roland Becker
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Quadriceps strength deficits are known for patients with knee osteoarthritis (OA), whereas findings on hamstrings are less clear. The Adaptive Force (AF) as a special neuromuscular function has never been investigated in OA before
Externí odkaz:
https://doaj.org/article/6ba36d8ab89d431c932e277bf8624f09
Autor:
Oneda Leka, Yufan Wu, Giulia Zanetti, Sven Furler, Thomas Reinberg, Joana Marinho, Jonas V. Schaefer, Andreas Plückthun, Xiaodan Li, Marco Pirazzini, Richard A. Kammerer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract In this study, we characterize Designed Ankyrin Repeat Proteins (DARPins) as investigative tools to probe botulinum neurotoxin A1 (BoNT/A1) structure and function. We identify DARPin-F5 that completely blocks SNAP25 substrate cleavage by BoN
Externí odkaz:
https://doaj.org/article/2e37d6fe1358488f9b33242c875dd948
Autor:
Alexander Strubel, Philipp Münick, Oliver Hartmann, Apirat Chaikuad, Birgit Dreier, Jonas V. Schaefer, Jakob Gebel, Christian Osterburg, Marcel Tuppi, Birgit Schäfer, Viktoria Buck, Mathias Rosenfeldt, Stefan Knapp, Andreas Plückthun, Markus E. Diefenbacher, Volker Dötsch
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-12 (2023)
Abstract The two p53 homologues p63 and p73 regulate transcriptional programs in epithelial tissues and several cell types in these tissues express both proteins. All members of the p53 family form tetramers in their active state through a dedicated
Externí odkaz:
https://doaj.org/article/af967dcb30b740eda6294164fd218dc4
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Diversity-oriented synthesis (DOS) is a powerful strategy to prepare molecules with underrepresented features in commercial screening collections, resulting in the elucidation of novel biological mechanisms. In parallel to the development of
Externí odkaz:
https://doaj.org/article/36c9d05209eb47b1b03cc9fce00df87d
Autor:
Jie Shi, Kristine Hauschulte, Ivan Mikicic, Srijana Maharjan, Valerie Arz, Tina Strauch, Jan B. Heidelberger, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Petra Beli, Helle D. Ulrich, Hans-Peter Wollscheid
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The actin cytoskeleton is of fundamental importance for cellular structure and plasticity. However, abundance and function of filamentous actin in the nucleus are still controversial. Here we show that the actin-based molecular motor myosin
Externí odkaz:
https://doaj.org/article/664388851c7f4b1e93e0bfdb9d7cdc53
Autor:
Claudia Christine E. Avila, Michael V. Schaefer, Alyssa M. Duro, Thomas P. Haensel, Abdi Garniwan, Ying Lin, G. Darrel Jenerette, Peter S. Nico, Eric Dubinsky, Marco Keiluweit, Eoin L. Brodie, Ying-Hsuan Lin, Peter M. Homyak, Samantha C. Ying
Publikováno v:
Geoderma, Vol 439, Iss , Pp 116681- (2023)
Drying-rewetting cycles are ubiquitous across natural and managed ecosystems. These cycles are known to mobilize carbon (C) in soils producing dramatic pulses in microbial respiration. While many factors contribute to these pulses, the drying-rewetti
Externí odkaz:
https://doaj.org/article/bca2041df0ab45d19b1c2452ab52ef4f
Autor:
Liam Hudson, Jeremy W. Mason, Matthias V. Westphal, Matthieu J. R. Richter, Jonathan R. Thielman, Bruce K. Hua, Christopher J. Gerry, Guoqin Xia, Heather L. Osswald, John M. Knapp, Zher Yin Tan, Praveen Kokkonda, Ben I. C. Tresco, Shuang Liu, Andrew G. Reidenbach, Katherine S. Lim, Jennifer Poirier, John Capece, Simone Bonazzi, Christian M. Gampe, Nichola J. Smith, James E. Bradner, Connor W. Coley, Paul A. Clemons, Bruno Melillo, C. Suk-Yee Hon, Johannes Ottl, Christoph E. Dumelin, Jonas V. Schaefer, Ann Marie E. Faust, Frédéric Berst, Stuart L. Schreiber, Frédéric J. Zécri, Karin Briner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d2f9e92baa034e31a3064fe3179e5c22
Publikováno v:
BMC Sports Science, Medicine and Rehabilitation, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract Background Isometric muscle actions can be performed either by initiating the action, e.g., pulling on an immovable resistance (PIMA), or by reacting to an external load, e.g., holding a weight (HIMA). In the present study, it was mainly exa
Externí odkaz:
https://doaj.org/article/3627a746d50149558be4329925ad5eaf
Autor:
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzym
Externí odkaz:
https://doaj.org/article/8cc716af995d44c680e7cd3d009fb03e
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
The Adaptive Force (AF) reflects the neuromuscular capacity to adapt to external loads during holding muscle actions and is similar to motions in real life and sports. The maximal isometric AF (AFisomax) was considered to be the most relevant paramet
Externí odkaz:
https://doaj.org/article/fb34086d53144b2da3427757e510daef