Fluorine-Containing Drugs Approved by the FDA in 2018

Autor: H. MEI, J. HAN, S. FUSTERO, M. MEDIO-SIMON, D. SEDGWICK, C. SANTI, R. RUZZICONI, V. SOLOSHONOK

Publikováno v: CHEMISTRY-A EUROPEAN JOURNAL
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname

Over the last two decades, fluorine substitution has become one of the essential structural traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster drugs) contain fluorine atoms. In this review, we profile 17 fluo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::509ca0d12a6c7f831163418176ad20ad
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3337

Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates

Autor: H. MEI, J. LIU, S. FUSTERO, R. ROMAN, R. RUZZICONI, V. SOLOSHONOK, J. HAN

Publikováno v: ORGANIC & BIOMOLECULAR CHEMISTRY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

This review article comprehensively profiles all literature reports (2015-2018) related to the detrifluoroacetylative in situ generation of fluorine-containing enolates and their reactions with electrophilic reagents. The innovative facets of this un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::47c4a0851a82457c876de0476584e40a
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2640

Recent progress in the application of fluorinated chiral sulfinimine reagents

Autor: H. MEI, J. HAN, S. FUSTERO, R. ROMAN, R. RUZZICONI, V. SOLOSHONOK

Publikováno v: JOURNAL OF FLUORINE CHEMISTRY
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname

The development of synthetic methodology allowing for a strategic incorporation of fluorine into target compounds is in a high demand in many areas of the chemical and pharmaceutical industries. In this regard, application of fluorinated chiral sulfi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1b182ce9e8091374141bba31955a5c0e
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2292

Operationally convenient, efficient asymmetric synthesis of enantiomerically pure 4-aminoglutamic acids via methylene dimerization of chiral glycine equivalents with dichloromethane

Autor: Takeshi Yamada, Tanner K. Cook, Anna M. Moore, Hisanori Ueki, Kelsey L. Arbogast, Yasufumi Ohfune, Collin H. Martin, Anatolii V. Soloshonok, Vadim A. Soloshonok

Publikováno v: Tetrahedron. 62:6412-6419

This paper presents a practical and efficient asymmetric synthesis of enantiomerically pure 4-aminoglutamic acids using a quite unusual methylene dimerization of chiral nucleophilic glycine equivalents with dichloromethane under phase-transfer cataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::200734f53727e71421e5c72682bbf11b
https://doi.org/10.1016/j.tet.2006.04.023

Synthesis of Fluorinated beta-Amino Acids

Autor: K. MIKAMI, S. FUSTERO, M. SANCHEZ-ROSELLO, J. ACENA, V. SOLOSHONOK, A. SOROCHINSKY

Publikováno v: SYNTHESIS-STUTTGART
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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The major goal of this review is to provide an overview of the general synthetic methods available in the literature for preparing fluorinated beta-amino acids and their derivatives. These compounds have been employed in combination with non-fluorina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4b46bcf92c2ed4eaf2de1173bbf96c47
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2477