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Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

Autor: H. F. Hodson, V. S. Rose, G. J. Blackwell, A. J. Parke, D. A. Sawyer, R. M. Hyde, L. Tilling, Derek A. Demaine, S. Smith, L.G. Garland

Publikováno v: European Journal of Medicinal Chemistry. 31:347-358

Summary This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0be1117ef0058344cb2255c06d88174
https://doi.org/10.1016/0223-5234(96)89161-6

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Quantitative structure chromatography relationships in reversed-phase high performance liquid chromatography: Prediction of retention behaviour using theoretically derived molecular properties

Autor: C. R. Beddell, Jeremy K. Nicholson, John C. Lindon, Ian D. Wilson, V. S. Rose, R.J. Ruane, R. C. Glen, P. Davis, Belinda C. Cupid

Publikováno v: Chromatographia. 37:241-249

The use of theoretically calculated molecular properties as predictors for retention in reversed-phase HPLC has been explored. HPLC retention times have been measured for a series of 47 substituted aromatic molecules in three solvent mixtures and ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8990047b31d5553712a3a7cdb1d99a3d
https://doi.org/10.1007/bf02278628

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ChemInform Abstract: Development of a Novel Series of Trialkoxyaryl Derivatives as Specific and Competitive Antagonists of Platelet Activating Factor

Autor: P. J. Islip, R. M. Beams, G. J. Blackwell, S. Smith, L. Tilling, L.G. Garland, A. J. Parke, R. M. Hyde, W. P. Jackson, Derek A. Demaine, N. J. Cheesman, V. S. Rose, H. F. Hodson, M. A. Brockwell, D. A. Sawyer, Peter John Wates

Publikováno v: ChemInform. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25d2e36ed991c74e53815fd815c37e6b
https://doi.org/10.1002/chin.199542099

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U. K. usage of chemometrics and artificial intelligence in QSAR analysis

Autor: V. S. Rose, R. M. Hyde, H. J. H. Macfie

Publikováno v: Journal of Chemometrics. 4:355-360

A survey of members of the U.K. QSAR Discussion Group has been made to determine the extent of use and development of chemometric and artificial intelligence (AI) methods in the analysis of multivariate quantitative structure–activity relationship

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a62064396ed5858e265a46f165924338
https://doi.org/10.1002/cem.1180040504

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