Zobrazeno 1 - 10
of 15
pro vyhledávání: '"V. S. Matiychuk"'
Publikováno v:
Фармацевтичний журнал, Vol 5, Pp 37-49 (2021)
One of the promising methods of creating antitumor drugs is the screening of potential antitumor agents among synthesized compounds. Nitrogen-based heterocycle analogues are an extremely important class of organic substances that are widely used in m
Externí odkaz:
https://doaj.org/article/f18de5a227b44a108103d684ac4cf43d
Publikováno v:
Фармацевтичний журнал, Vol 1, Pp 17-25 (2021)
As a result of metabolic transformations of substances in the human body in the reactions of lipid peroxidation, reactive oxygen species are formed. Normally, the regulation of the production of activated oxygen metabolites and free radicals in human
Externí odkaz:
https://doaj.org/article/1cf91c6d8d734d81afce7f72454489e5
Publikováno v:
The Ukrainian Biochemical Journal, Vol 92, Iss 2, Pp 132-139 (2020)
In an effort to develop novel anti-inflammatory agents, a series of thiazolo[4,5-b]pyridines were synthesized and modified at the N3 position. The structures of the obtained compounds were confirmed by 1H NMR spectroscopy and elemental analysis. The
Externí odkaz:
https://doaj.org/article/242d7b3868fa42f2835fa3987cd0e259
Autor:
N. S. Finiuk, I. I. Ivasechko, O. Yu. Klyuchivska, Yu. V. Ostapiuk, V. P. Hreniukh, Ya. R. Shalai, V. S. Matiychuk, M. D. Obushak, A. M. Babsky, R. S. Stoika
Publikováno v:
The Ukrainian Biochemical Journal, Vol 91, Iss 2, Pp 29-39 (2019)
Derivatives of 2-amino-5-benzylthiazole are heterocyclic pharmacophores that exhibit different pharmacological activities including anticancer action. The mechanisms of such action of these compounds are not clear. The aim of the present study was to
Externí odkaz:
https://doaj.org/article/27ac830802be498180465ac22808e03e
Autor:
N. S. Finiuk, V. P. Hreniukh, Yu. V. Ostapiuk, V. S. Matiychuk, M. D. Obushak, R. S. Stoika, A. M. Babsky
Publikováno v:
Біологічні студії, Vol 12, Iss 2, Pp 25-34 (2018)
We have found that new derivatives of 2-amino-5-benzylthiazole possess cytotoxic action towards human tumor cells (Finiuk et al., Biopolym. Cell, 2017; Finiuk et al., Ukr. Biochem. J., 2018). A release of the chemotherapeutic drugs into the environme
Externí odkaz:
https://doaj.org/article/c8b6405b53a641a1a8c46635654e359b
Autor:
N. S. Finiuk, Yu. V. Ostapiuk, V. P. Hreniukh, Ya. R. Shalai, V. S. Matiychuk, M. D. Obushak, R.S. Stoika, A. M. Babsky
Publikováno v:
The Ukrainian Biochemical Journal, Vol 90, Iss 2, Pp 25-32 (2018)
The research aim was to test cytotoxic effects in vitro of seven novel pyrazolothiazolopyrimidine derivatives in targeting several lines of tumor and pseudo-normal mammalian cells. We demonstrated that cytotoxic effects of these derivatives depended
Externí odkaz:
https://doaj.org/article/1a4cae2bcb594d4fa9447dd12781bbc6
Publikováno v:
Chemistry, Technology and Application of Substances. 2:12-17
Publikováno v:
Фармацевтичний часопис, Vol 0, Iss 2 (2018)
The aim of the work. Development of methods for obtaining new morpholin-4-yl-2-thioxoacetamides and investigate their reaction with 1,3-diaminopropane; synthesis of new 1,4,5,6-tetrahydropyrimidine-2-carboxamides and primary screening of their anti-i
Publikováno v:
Фармацевтичний часопис, Vol 0, Iss 3 (2017)
The aim of the work. Synthesis of 5-(4-R-benzyl)thiazol-2-yl]-2-[5-(4-R1-benzylidene)-4-oxo-2-thioxothiazolidin-3-yl]acet- and propionamides and study of their antimicrobial activity. Materials and Methods. Traditional methods of organic synthesis du
Publikováno v:
Фармацевтичний часопис, Vol 0, Iss 2 (2017)
The aim of the work. Synthesis of new 6-(N/Me)-N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5,6,7-tetrahydro-1-benzothiophen-3-carboxamides and investigation of their antitumor activity. Materials and Methods. It was used traditional methods of organic synthesi