Zobrazeno 1 - 10
of 24
pro vyhledávání: '"V. S. Manu"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Nuclear magnetic resonance (NMR) spectroscopy is a powerful high-resolution tool for characterizing biomacromolecular structure, dynamics, and interactions. However, the lengthy longitudinal relaxation of the nuclear spins significantly exte
Externí odkaz:
https://doaj.org/article/d2548c32c7ba46419c1e2861249f073b
Autor:
Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V. S. Manu, Fernando Porcelli, Donald K. Blumenthal, David D. Thomas, David A. Bernlohr, Simon M. Sandford, Susan S. Taylor, Gianluigi Veglia
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Olivieri, Walker, Karamafrooz et al. show that the fusion of the dynamic J-domain to PKA-C (PKA-CDNAJB1) disrupts the internal allosteric network, attenuating the nucleotide/PKI binding cooperativity. This study suggests that the reduced allosteric c
Externí odkaz:
https://doaj.org/article/43c1fcd3a0854b83a040ab4779192c9e
Autor:
Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, Yingjie Wang, V. S. Manu, Fernando Porcelli, Donald K. Blumenthal, David D. Thomas, David A. Bernlohr, Sanford M. Simon, Susan S. Taylor, Gianluigi Veglia
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-02006-3
Externí odkaz:
https://doaj.org/article/7c24fd9db8f04d64a2a736102b658354
Publikováno v:
Journal of Biomolecular NMR. 77:1-14
The nuclear Overhauser effect (NOE) is one of NMR spectroscopy's most important and versatile parameters. NOE is routinely utilized to determine the structures of medium-to-large size biomolecules and characterize protein-protein, protein-RNA, protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e8f2a1d51f0bf100c7614d36c287d8
https://doi.org/10.1007/s10858-022-00407-y
https://doi.org/10.1007/s10858-022-00407-y
Autor:
Olivieri, Cristina, Li, Geoffrey C, Wang, Yingjie, V S, Manu, Walker, Caitlin, Kim, Jonggul, Camilloni, Carlo, De Simone, Alfonso, Vendruscolo, Michele, Bernlohr, David A, Taylor, Susan S, Veglia, Gianluigi
ATP-competitive inhibitors are currently the largest class of clinically approved drugs for protein kinases. By targeting the ATP-binding pocket, these compounds block the catalytic activity, preventing substrate phosphorylation. A problem with these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7919b850560239fd12934d708db114
http://hdl.handle.net/2434/937028
http://hdl.handle.net/2434/937028
Publikováno v:
Physical Chemistry Chemical Physics. 24:18477-18481
Water suppression is of paramount importance for many biological and analytical NMR spectroscopy applications. Here, we report the design of a new set of binomial-like radio frequency (RF) pulses that elude water irradiation while exciting or refocus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed45d71a7d60991a464325b4d0101cc
https://doi.org/10.1039/d2cp01744j
https://doi.org/10.1039/d2cp01744j
High-fidelity control of spin ensemble dynamics is essential to many fields, spanning from quantum computing to optical, coherent, and nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI). However, attaining robust and high-fidelity quantu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3d19ad2d4e9fc8500050ae68cd72bd6
https://doi.org/10.21203/rs.3.rs-403351/v1
https://doi.org/10.21203/rs.3.rs-403351/v1
Autor:
Simon M. Sandford, Fernando Porcelli, Cristina Olivieri, V. S. Manu, David D. Thomas, Donald K. Blumenthal, Susan S. Taylor, Caitlin Walker, Yingjie Wang, Gianluigi Veglia, David A. Bernlohr, Adak Karamafrooz
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
An aberrant fusion of the DNAJB1 and PRKACA genes generates a chimeric protein kinase (PKA-CDNAJB1) in which the J-domain of the heat shock protein 40 is fused to the catalytic α subunit of cAMP-dependent protein kinase A (PKA-C). Deceivingly, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddef787b3b19f9011cc55607bf5fa7f3
http://europepmc.org/articles/PMC7946884
http://europepmc.org/articles/PMC7946884
Autor:
Gianluigi Veglia, V. S. Manu
Publikováno v:
Journal of Magnetic Resonance. 273:40-46
Identity operation in the form of π pulses is widely used in NMR spectroscopy. For an isolated single spin system, a sequence of even number of π pulses performs an identity operation, leaving the spin state essentially unaltered. For multi-spin sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea29345e2c773c42c750a76872257fb
https://doi.org/10.1016/j.jmr.2016.09.021
https://doi.org/10.1016/j.jmr.2016.09.021
Autor:
Donald K. Blumenthal, Yingjie Wang, Sanford M. Simon, Caitlin Walker, V. S. Manu, Fernando Porcelli, David D. Thomas, Cristina Olivieri, Gianluigi Veglia, Susan S. Taylor, David A. Bernlohr, Adak Karamafrooz
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Communications Biology
Communications Biology
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-02006-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b41580d94de0a1a7571c2747183d2fe
https://doaj.org/article/7c24fd9db8f04d64a2a736102b658354
https://doaj.org/article/7c24fd9db8f04d64a2a736102b658354