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Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats
Publikováno v:
Journal of Applied Physiology. 79:2122-2131
The current study examined the effects of bosentan, an orally active antagonist of endothelin-A and -B receptors, on the development and maintenance of hypoxia (10% O2)-induced pulmonary hypertension and vascular remodeling in the rat. Pretreatment w