Zobrazeno 1 - 10
of 34
pro vyhledávání: '"V. Raj Gopal"'
Autor:
Chary, V Raj Gopal1
Publikováno v:
European Journal of Cardiovascular Medicine. 2022, Vol. 12 Issue 2, p84-87. 4p.
Autor:
Chary, V Raj Gopal1
Publikováno v:
European Journal of Cardiovascular Medicine. 2022, Vol. 12 Issue 2, p79-83. 5p.
Autor:
Bhavani Sangras, R. V. Krishna Kishore, V. Raj Gopal, Blythe B. Holmes, Wenqi Yang, John R. Falck, Xiu Yu Yi, William B. Campbell
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:1023-1031
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of arachidonic acid. EETs mediate numerous biological functions. In coronary arteries, they regulate vascular tone by the activation of smooth muscle large-conductance, calc
Autor:
Shawn D. Harmon, Terry L. Kaduce, Shanming Hu, V. Raj Gopal, Xiang Fang, John R. Falck, Arthur A. Spector
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 75:169-177
Cytochrome P450 (CYP) omega-oxidases convert arachidonic acid (AA) to 20-hydroxyeicosatetraenoic acid (20-HETE), a lipid mediator that modulates vascular tone. We observed that a microsomal preparation containing recombinant human CYP4F3B, which conv
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 49:245-252
Deuterated arachidonic acid and 20-HETE were prepared in good overall yields and high stereoselectivities. Key transformations include a trans-specific vinyl dibromide reduction and Suzuki cross-couplings to a lithium borate or a 9-BBN borane. These
Publikováno v:
Analytical Biochemistry. 332:137-144
Endogenous trans fatty acids originate from diet, but recent studies also suggest that cis–trans isomerization of fatty acids is possible by nitrogen dioxide radical, a product of NO and nitrite oxidation. We developed a method for quantitative ana
Autor:
Terry L. Kaduce, Lynn M. Teesch, Arthur A. Spector, V. Raj Gopal, Kevin C. Dellsperger, Neal L. Weintraub, Shawn D. Harmon, John R. Falck, William B. Campbell, Christine L. Oltman, Xiang Fang
Publikováno v:
Journal of Biological Chemistry. 279:2648-2656
We have investigated the role of endothelial cells in the metabolism of 20-hydroxyeicosatetraenoic acid (20-HETE), a vasoactive mediator synthesized from arachidonic acid by cytochrome P450 omega-oxidases. Porcine coronary artery endothelial cells (P
Autor:
Mong Heng Wang, V. Raj Gopal, Ji Shi Wang, Alberto Nasjletti, Michal Laniado-Schwartzman, John R. Falck, Fan Zhang, Jun Ichi Kaide
Publikováno v:
American Journal of Physiology-Renal Physiology. 284:F51-F56
20-HETE, a cytochrome P-450 4A (CYP4A1)-derived arachidonic acid metabolite, is a major eicosanoid formed in renal and extrarenal microcirculation. 20-HETE inhibits Ca2+-activated K+ channels in vascular smooth muscle cells and thereby may modulate v
Autor:
Cassandra E, Deering-Rice, Virginia K, Mitchell, Erin G, Romero, May H, Abdel Aziz, Daniel A, Ryskamp, David, Križaj, V Raj, Gopal, Christopher A, Reilly
Publikováno v:
Pharmacology Research & Perspectives
Transient receptor potential vanilloid-3 (TRPV3) is a member of the TRPV subfamily of TRP ion channels. The physiological functions of TRPV3 are not fully understood, in part, due to a lack of selective agonists and antagonists that could both facili
Publikováno v:
Journal of Photochemistry and Photobiology A: Chemistry. 117:99-104
Photochemical electron transfer (PET) reactions were carried out using PET sensitizer (TPT) and dichalcogenides (DPDT/DPDS). Sensitizer fluorescence quenching by dichalcogenides is found to be very efficient and it leads to the electron-transfer proc