Long-term persistence of low-molecular-weight material with anti-factor Xa activity contributes to anticoagulant and antithrombotic effects after subcutaneous injection of CY 216 in the rabbit

Autor: V. Peyrou, J. P. Herault, Jean-Marc Herbert, B. Boneu, J C Lormeau

Publikováno v: Blood Coagulation & Fibrinolysis. 8:175-184

This study was done to document further the mechanism of the antithrombotic effect of CY 216 after subcutaneous injection in the rabbit. We first measured the circulating anti-factor Xa and anti-thrombin activities expressed in either International U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8525751f294a9c8d26773f4347df89ea
https://doi.org/10.1097/00001721-199704000-00004

Pharmacological Properties of CY 216 and of Its ACLM and BCLM Components in the Rabbit

Autor: S Saivin, A.M. Gabaig, Pierre Sie, Jean-Claude Lormeau, G Houin, Bernard Boneu, C. Caranobe, V. Peyrou, B. Crepon

Publikováno v: Scopus-Elsevier

SummaryThis study compares some in vivo pharmacological properties of CY 216 and of its ACLM and BCLM components having a molecular weight above and below 5.4 kDa respectively. The anti-factor Xa/anti-thrombin ratio of these compounds determined in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985a290581fbbb37e5d0b2c1b58cce25
https://doi.org/10.1055/s-0038-1648851

Synthesis and in vitro Trichomonacidal activities of some new dialkylperoxides and 1,2,4-trioxanes

Autor: B, Camuzat-Dedenis, O, Provot, L, Cointeaux, V, Peyrou, J F, Berrien, C, Bories, P M, Loiseau, J, Mayrargue, V, Perroux

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2001, 36 (10), pp.837-842. ⟨10.1016/S0223-5234(01)01278-8⟩

Two series of three trioxanes and 18 disubstituted peroxides were synthesised and evaluated for their in vitro trichomonacidal activity against Trichomonas vaginalis . The most active compound, 2-methylprop-2-yl 2-methoxyeth-1-yl peroxide exhibited a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b41cfffc0c8772d97eeac7720ea6b885
https://hal.archives-ouvertes.fr/hal-02402911

The activity of unfractionated heparin and low molecular weight heparins in rabbit plasma--the need for using absolute anti-factor Xa and antithrombin activities

Autor: V, Peyrou, S, Béguin, B, Boneu, H C, Hemker

Publikováno v: Thrombosis and haemostasis. 77(2)

Rabbit being a common animal model to evaluate the antithrombotic effect of heparins, our purpose was to apply the heparin Standard Independent Unit (SIU) approach to rabbit plasma. To take into account the specificities of the enzymes we have measur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4063e5005ca905d0f53f685ae254d83d
https://pubmed.ncbi.nlm.nih.gov/9157588

From Stilbenes to carbo-Stilbenes: an Encouraging Prospect.

Autor: Zhu C; Faculté Science et Ingénierie - Département de Chimie., Unsaturated molecules for physics, biology and chemistry group., Université Toulouse III - Paul Sabatier, 118 route de Narbonne, 31-062, Toulouse Cedex 09, France.; Key Laboratory of Functional Molecular Solids, Ministry of Education, and School of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241002, China., Saquet A; LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France., Maraval V; LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France., Bijani C; LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France., Cui X; Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China., Poater A; Institut de Química Computacional i Catàlisi, Departament de Química, Universitat de Girona, c/ Mª Aurèlia, Capmany 69, 17003, Girona, Catalonia, Spain., Chauvin R; Faculté Science et Ingénierie - Département de Chimie., Unsaturated molecules for physics, biology and chemistry group., Université Toulouse III - Paul Sabatier, 118 route de Narbonne, 31-062, Toulouse Cedex 09, France.; Engineering Research Center of Molecular Medicine of Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 May 08; Vol. 30 (26), pp. e202400451. Date of Electronic Publication: 2024 Mar 13.