Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus

Autor: Mary Gazea, Osborne F. X. Almeida, Zsolt Liposits, Nils C. Gassen, Este Leidmaa, Imre Kalló, Mayumi Kimura, Anna Pissioti, Alexandre V. Patchev

Publikováno v: Acta physiologica (Oxford, England)REFERENCES. 228(2)

Since foods with high hedonic value are often consumed in excess of energetic needs, this study was designed to identify the mechanisms that may counter anorexigenic signalling in the presence of hedonic foods in lean animals.Mice, in different state

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab178e1882a53f7aeca4f2ee197224ee
https://pubmed.ncbi.nlm.nih.gov/31310704

Antidepressant responsiveness in adulthood is permanently impaired after neonatal destruction of the neurogenic pool

Autor: Alexandre V. Patchev, Osborne F. X. Almeida, Patrício Costa, Ipshita Zutshi, Shuang Yu, Florian Holsboer, Jingzhong Zhang, Rainer Stoffel, Nuno Sousa, Ana Paula Ventura-Silva

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Translational Psychiatry
TRANSLATIONAL PSYCHIATRY

The dynamic turnover of hippocampal neurons is implicated in the regulation of cognitive and affective behavior. Extending our previous demonstration that administration of dexamethasone (ND) to neonatal rats depletes the resident population of neura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c0cc095c2a5748c789cc28debac462
https://hdl.handle.net/1822/58185

Early-Life Stress Reduces DNA Methylation of the Pomc Gene in Male Mice

Autor: Guillaume Daniel, Alexandre V. Patchev, Yonghe Wu, Osborne F. X. Almeida, Dietmar Spengler

Publikováno v: Endocrinology. 155:1751-1762

Early-life stress (ELS) increases the vulnerability thresholds for stress-related diseases such as major depression and anxiety by inducing alterations in the structure and function of neural circuits and endocrine pathways. We previously demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f714244e5ec7dc26dab4cb447ffb17e
https://doi.org/10.1210/en.2013-1868

Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress

Autor: Arleta Madejska, João Carlos Sousa, Alexandre V. Patchev, Florian Holsboer, Anke Hoffmann, Yvonne Bockmühl, Dietmar Spengler, Osborne F. X. Almeida, Nuno Sousa

Publikováno v: Epigenetics
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Early-life stress (ELS) induces long-lasting changes in gene expression conferring an increased risk for the development of stress-related mental disorders. Glucocorticoid receptors (GR) mediate the negative feedback actions of glucocorticoids (GC) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f61c55110dfa91f3d5eaeb5470a0f10

Neurotropic action of androgens: principles, mechanisms and novel targets

Autor: Alexandre V. Patchev, Jens Schroeder, Franziska Goetz, Vladimir K. Patchev, Wolfgang Rohde

Publikováno v: Experimental Gerontology. 39:1651-1660

The importance of androgen signaling is well recognized for numerous aspects of central nervous system (CNS) function, ranging from sex-specific organization of neuroendocrine and behavioral circuits to adaptive capacity, resistance and repair. Nonet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60973d99454485879092a2d9260e510d
https://doi.org/10.1016/j.exger.2004.07.011