Zobrazeno 1 - 10
of 43
pro vyhledávání: '"V. P. Pisarev"'
Autor:
V. V. Pisarev, A. V. Ivanov
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 13, Iss 2, Pp 181-189 (2024)
Introduction. One of the reasons for the development of many diseases primarily malignant is the increased expression of Vascular Endothelial Growth Factor (VEGF). Bevacizumab is a drug that neutralizes the biological activity of VEGF. The molecular
Externí odkaz:
https://doaj.org/article/5b7f447674b74c18a5b177b30538c5b4
Publikováno v:
Общая реаниматология, Vol 20, Iss 2, Pp 14-28 (2024)
The mortality rate among patients with acute suppurative lung diseases (ASLD) in the ICU reaches 30%. Early, pathogenetically relevant biomarkers are needed to ensure personification and better efficacy of ASLD treatment. Numeric variations in the c
Externí odkaz:
https://doaj.org/article/019a80ef298e48c7b824868941e7189c
Publikováno v:
Общая реаниматология, Vol 19, Iss 5, Pp 4-12 (2023)
Aquaporins 4 and 5 are proteins that form water channels in the cell membrane, participate in the transfer and migration of immune cells, being expressed on many cell types including CNS astrocytes, kidney cells, lungs, and the immune system. We have
Externí odkaz:
https://doaj.org/article/589a4b7c7b9844adb66c69dfeaefc43a
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 12, Iss 3, Pp 240-249 (2023)
Introduction. Trastuzumab is the first drug based on the monoclonal antibodies’ technology targeted to the neu oncogene expression product discovered in the middle 80-s – human epidermal growth receptor, HER2. After being approved trastuzumab had
Externí odkaz:
https://doaj.org/article/60567173043c4434badf112989e98f06
Autor:
V. V. Pisarev, A. V. Ivanov
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 58-64 (2023)
Relevance. Trastuzumab is the drug of choice for the HER2+ breast cancer treatment. To determine the trastuzumab pharmacodynamics in personalized therapy a validated bioanalytical method for measuring the concentration of the drug in biological fluid
Externí odkaz:
https://doaj.org/article/9d26f833cf664e819c7751ee15231f74
Publikováno v:
Общая реаниматология, Vol 17, Iss 5, Pp 35-51 (2021)
Blood pressure dysregulation and circulatory failure are major contributors to the progression of sepsis and especially septic shock. One of the genes affecting the vascular endothelium and arteriolar tone is the angiotensin II receptor 1 gene (AGTR1
Externí odkaz:
https://doaj.org/article/b28105b1b7c3486687f25a373aeff400
Publikováno v:
Медицинская иммунология, Vol 22, Iss 6, Pp 1065-1084 (2021)
Bacterial extracellular microvesicles (BMV) are formed by nonpathogenic, pathogenic and opportunistic bacteria. BMV are spherical bilayer-membrane organelles containing different cargoes: lipopolysaccharides, pathogen associated molecular patterns (P
Externí odkaz:
https://doaj.org/article/6ebc6939f8734ee0a13c29e04d903531
Publikováno v:
Общая реаниматология, Vol 16, Iss 6, Pp 31-53 (2020)
Aim of the study: to evaluate safety and feasibility of clinical use of an extracorporeal blood adsorber based on a hypercrosslinked styrene-divinylbenzene copolymer with immobilized lipopolysaccharide (LPS)-selective ligand designed to remove endoto
Externí odkaz:
https://doaj.org/article/d5751b6e593d42db88a2825ebe5651ad
Autor:
A. D. Filev, V. M. Pisarev
Publikováno v:
Неотложная медицинская помощь, Vol 9, Iss 1, Pp 96-107 (2020)
ABSTRACT. Defining molecules with high prognostic value for predicting the course and outcomes of life-threatening sepsis, severe injuries, vascular accidents remains an urgent problem in emergency medicine. One of the promising candidate biomarkers
Externí odkaz:
https://doaj.org/article/8ae6a68e983145f2a6c802d856f2124c
Autor:
V. M. Pisarev, A. G. Chumachenko, I. N. Turin, R. A. Cherpakov, E. V. Elisina, E. K. Grigoriev, I. A. Aleksandrov, A. V. Tutelyan
Publikováno v:
Общая реаниматология, Vol 16, Iss 3, Pp 16-33 (2020)
Aquaporins represent proteins contributed to water transport through cell membrane. They are involved in formation and resolution of edema, cell migration and inflammatory reaction. There are only few studies linking the genetic polymorphism of aqua
Externí odkaz:
https://doaj.org/article/a711e6e1ba7a4b38ba608a2dfd628a44