Zobrazeno 1 - 10
of 61
pro vyhledávání: '"V. P. Nikolin"'
Autor:
G. S. Ritter, V. P. Nikolin, N. A. Popova, A. S. Proskurina, P. E. Kisaretova, O. S. Taranov, T. D. Dubatolova, E. V. Dolgova, E. A. Potter, S. S. Kirikovich, Y. R. Efremov, S. I. Bayborodin, M. V. Romanenko, M. I. Meschaninova, A. G. Venyaminova, N. A. Kolchanov, S. S. Bogachev
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 24, Iss 6, Pp 643-652 (2020)
The paper describes some biological features of the radioprotective effect of double-stranded RNA preparation. It was found that yeast RNA preparation has a prolonged radioprotective effect after irradiation by a lethal dose of 9.4 Gy. 100 % of anima
Externí odkaz:
https://doaj.org/article/785a47b5e27645359947c5f4ed081264
Autor:
S. I. Oshevski, Y. I. Ragino, E. V. Kashtanova, Y. V. Polonskaya, E. M. Stakhneva, V. P. Nikolin, N. A. Popova, N. A. Kolchanov, M. I. Voevoda
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 23, Iss 8, Pp 1020-1025 (2020)
Development of new drugs able to decrease the level of “bad” cholesterol, in particular, based on antisense oligonucleotide derivatives (ASOs), remains relevant for the patients with familial hypercholesterolemia and/or intolerant to statins. The
Externí odkaz:
https://doaj.org/article/dfce909fe63a4b08ad14f9a1cb367e93
Autor:
S. I. Oshevskii, Yu. I. Ragino, E. V. Kashtanova, Yu. V. Polonskaya, E. M. Stakhneva, V. P. Nikolin, N. A. Popova, N. A. Kolchanov, M. I. Voevoda
Publikováno v:
Атеросклероз, Vol 13, Iss 2, Pp 12-17 (2017)
Objective: To assess the potential of a new approach to altering the heart rate by expression inhibition of the SCN5A gene, encoding a classical sodium channel, Nav1.5, with an antisense oligonucleotide derivative in the case study of the mouse. Mate
Externí odkaz:
https://doaj.org/article/7a694bcacb77474e9c1f62a209033206
Autor:
E. A. Potter, E. V. Dolgova, A. M. Minkevich, V. P. Nikolin, N. A. Popova, Ya. R. Efremov, S. I. Baiborodin, V. A. Rogachev, A. S. Proskurina, O. S. Taranov, E. I. Vereschagin, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 20, Iss 5, Pp 716-722 (2016)
Previously, we reported on the development of a therapeutic regimen allowing eradication of primary murine Krebs-2 ascites transplants. This protocol involved multiple injections of dsDNA preparations administered during the NER and HR phases of repa
Externí odkaz:
https://doaj.org/article/72e755fdce694cac9febfbc60bf7e694
Autor:
E. A. Potter, E. V. Dolgova, A. S. Proskurina, Ya. R. Efremov, O. S. Taranov, V. P. Nikolin, N. A. Popova, T. D. Dubatolova, D. D. Petrova, E. I. Vereschagin, A. M. Minkevich, O. M. Andrushkevich, S. I. Baiborodin, V. A. Rogachev, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 20, Iss 5, Pp 723-735 (2016)
Cumulative evidence obtained in this series of studies has guided the logic behind the development of a novel composite dsDNA-based preparation whose therapeutic application according to the specific regimen completely cures the mice engrafted with o
Externí odkaz:
https://doaj.org/article/e7fd54bf5cf44d82ae8553d602bbce45
Autor:
E. A. Potter, E. V. Dolgova, A. M. Minkevich, Ya. R. Efremov, O. S. Taranov, V. V. Omigov, V. P. Nikolin, N. A. Popova, A. S. Proskurina, E. I. Vereschagin, A. V. Kozel, V. A. Rogachev, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 20, Iss 1, Pp 96-107 (2016)
Existence of a small subset of cancer cells referred to as tumor initiating stem cells (TISCs) largely responsible for tumor progression and resistance to chemotherapeutic cytostatic drugs reperesent an important recent paradigm shift. The present wo
Externí odkaz:
https://doaj.org/article/286909d4625d482ead65a231e57499c6
Autor:
E. A. Potter, E. V. Dolgova, A. M. Minkevich, V. P. Nikolin, N. A. Popova, Ya. R. Efremov, S. I. Baiborodin, V. A. Rogachev, A. S. Proskurina, A. V. Kozel, O. S. Taranov, V. V. Omigov, E. I. Vereschagin, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 20, Iss 1, Pp 108-124 (2016)
In the present paper, we report on the series of experiments where multiple regimens of CP and dsDNA injections were tested for targeting the ascites form of murine Krebs-2 cancer in situ. We show that combining CP with cross-linked human and salmon
Externí odkaz:
https://doaj.org/article/a3409f93c89b4dfb93bf13e315d496f0
Autor:
S. I. Oshevskii, Yu. I. Ragino, E. V. Kashtanova, Ya. V. Polonskaya, E. M. Stakhneva, V. P. Nikolin, N. A. Popova, A. N. Korablev, N. A. Kolchanov, M. I. Voevoda
Publikováno v:
Атеросклероз, Vol 11, Iss 3, Pp 72-78 (2015)
Motivation and Aim: Demonstration of the possibility of lipid metabolism regulation by joint action of several antisense oligonucleotide derivatives (ASOs) targeted to mRNAs of closely associated proteins involved in lipid metabolism. Material an
Externí odkaz:
https://doaj.org/article/6c7e3a3f49bc4cdeb318ab9eea70d244
Autor:
E. V. Dolgova, A. V. Prokopenko, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. V. Panov, S. N. Zagrebelnyi, M. A. Shurdov
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 17, Iss 2, Pp 246-264 (2014)
Mice were observed to get sick and die upon administration of exogenous DNA in a specific period of time following their pretreatment with the cytostatic cyclophosphamide (CP) (Dolgova et al., 2011). It was established that exogenous DNA reaches inte
Externí odkaz:
https://doaj.org/article/74a6e7efc58746fcad4288b140992e8f
Autor:
E. V. Dolgova, V. P. Nikolin, N. A. Popova, A. S. Proskurina, K. E. Orishchenko, E. A. Alyamkina, Ya. R. Efremov, S. I. Baiborodin, E. R. Chernykh, A. A. Ostanin, S. S. Bogachev, T. S. Gvozdeva, E. M. Malkova, O. S. Taranov, V. A. Rogachev, A. S. Panov, S. N. Zagrebelnyi, M. A. Shurdov
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 17, Iss 1, Pp 129-146 (2014)
The synergic action of the cytostatic drug cyclophosphamide (CP) and fragmented exogenous DNA causes illness and death in mice (Dolgova et al., 2011–2013). The observed «delayed death» effect was most clearly pronounced when the DNA preparation w
Externí odkaz:
https://doaj.org/article/8a8485cb8bd04035b5de9e6b8ffe1a6a