The Calcium-Modulated Structures of Calmodulin and S100b Proteins are Useful to Monitor Hydrogen/Deuterium Exchange Efficiency Using Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry

Autor: Victor V. Ozols, Haroon Saleem, Richard S Burns, Peter L Pingerelli, Carly R Anderson

Publikováno v: European Journal of Mass Spectrometry. 15:739-746

Hydrogen/deuterium exchange (HDX) using matrix-assisted laser desorption ionization time-of-flight (MALDI-ToF) mass spectrometry is a sensitive, salt-tolerant and high-throughput method useful to probe protein conformation and molecular interactions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90f5f39159d750e8bda38c39f0e8717
https://doi.org/10.1255/ejms.1030

Diverse compounds mimic Alzheimer disease–causing mutations by augmenting Aβ42 production

Autor: Victor V. Ozols, Murad Ali Khan, Michael P. Murphy, Jenny Beard, Sarah A. Sagi, Pritam Das, Sami L. Merit, Jason L. Eriksen, Rajashaker Kache, Abdul H. Fauq, Tawnya E. Smith, Thomas Kukar, Mark K. Dodson, Sascha Weggen, Todd E. Golde, Edward H. Koo, Thomas B. Ladd, Panos Z. Anastasiadis

Publikováno v: Nature Medicine. 11:545-550

Increased Abeta42 production has been linked to the development of Alzheimer disease. We now identify a number of compounds that raise Abeta42. Among the more potent Abeta42-raising agents identified are fenofibrate, an antilipidemic agent, and celec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845ee8f1866fb3c2aad3d8734f299d7d
https://doi.org/10.1038/nm1235

Wnt pathway in atypical teratoid rhabdoid tumors

Autor: Parth Chodavadia, Ratan D. Bhardwaj, Daniel Catchpoole, Jingying Xu, Madhavi Chakravadhanula, Victor V. Ozols, Chris Hampton, Li Zhou, Anat Erdreich-Epstein

Atypical teratoid rhabdoid tumor (ATRT) is an aggressive tumor comprising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4507ea1a614a32ed6fb663697ab8cece
https://europepmc.org/articles/PMC4483069/

Identification of an asparagine amidohydrolase from the filarial parasite Dirofilaria immitis1The nucleotide sequence reported in this paper has been submitted to the GenBank database with accession number AF116552.1

Autor: Aaron B Carmody, Ramaswamy Chandrashekar, Naotoshi Tsuji, Victor V. Ozols, Tony H. Morales

Publikováno v: International Journal for Parasitology. 29:1451-1455

The nematode cuticle is a complex extracellular structure which is secreted by an underlying syncytium of hypodermal cells. Recent studies have demonstrated that the cuticle of parasitic nematodes is a dynamic structure with important absorptive, sec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::445503a2267746b62c7307472ee8ce85
https://doi.org/10.1016/s0020-7519(99)00087-9

IMMUNOTHERAPY/BIOLOGICAL THERAPIES

Autor: J. Campian, D. Gladstone, P. Ambady, X. Ye, K. King, I. Borrello, S. Petrik, M. Golightly, M. Holdhoff, S. Grossman, R. Bhardwaj, M. Chakravadhanula, V. Ozols, J. Georges, E. Carlson, C. Hampton, W. Decker, Y. Chiba, N. Hashimoto, N. Kagawa, R. Hirayama, A. Tsuboi, Y. Oji, Y. Oka, H. Sugiyama, T. Yoshimine, B. Choi, P. Gedeon, J. Herndon, L. Sanchez-Perez, D. Mitchell, D. Bigner, J. Sampson, Y. A. Choi, H. Pandya, D. M. Gibo, W. Debinski, T. F. Cloughesy, L. M. Liau, E. A. Chiocca, D. J. Jolly, J. M. Robbins, D. Ostertag, C. E. Ibanez, H. E. Gruber, N. Kasahara, M. A. Vogelbaum, S. Kesari, T. Mikkelsen, S. Kalkanis, J. Landolfi, S. Bloomfield, G. Foltz, D. Pertschuk, R. Everson, R. Jin, M. Safaee, D. Lisiero, S. Odesa, L. Liau, R. Prins, S. Gholamin, S. S. Mitra, C. E. Richard, A. Achrol, S. A. Kahn, A. K. Volkmer, J. P. Volkmer, S. Willingham, D. Kong, J. J. Shin, M. Monje-Deisseroth, Y.-J. Cho, I. Weissman, S. H. Cheshier, Y. Kanemura, M. Sumida, E. Yoshioka, A. Yamamoto, D. Kanematsu, A. Takada, M. Nonaka, S. Nakajima, S. Goto, T. Kamigaki, M. Takahara, R. Maekawa, T. Shofuda, S. Moriuchi, M. Yamasaki, R. Kebudi, F. B. Cakir, O. Gorgun, F. Y. Agaoglu, E. Darendeliler, Y. Lin, Y. Wang, X. Qiu, T. Jiang, G. Zhang, J. Wang, H. Okada, L. Butterfield, R. Hamilton, J. Drappatz, J. Engh, N. Amankulor, M. Lively, M. Chan, A. Salazar, D. Potter, E. Shaw, F. Lieberman, Y. Choi, J. Park, S. Phuphanich, C. Wheeler, J. Rudnick, J. Hu, M. Mazer, H. Wang, M. Nuno, A. Guevarra, C. Sanchez, X. Fan, J. Ji, R. Chu, J. Bender, E. Hawkins, K. Black, J. Yu, E. Reap, G. Archer, P. Norberg, R. Schmittling, S. Nair, X. Cui, D. Snyder, V. Chandramohan, C.-T. Kuan, H. Yan, D. Reardon, G. Li, L. Recht, K. Fink, L. Nabors, D. Tran, A. Desjardins, N. Chandramouli, J. P. Duic, M. Groves, A. Clarke, T. Hawthorne, J. Green, M. Yellin, G. Rigakos, O. Spyri, P. Nomikos, F. Stavridi, I. Grossi, I. Theodorakopoulou, A. Assi, G. Kouvatseas, E. Papadopoulou, G. Nasioulas, S. Labropoulos, E. Razis, A. Ravi, D. N. Tang, P. Sharma, S. Sengupta, P. Sampath, H. Soto, K. Erickson, C. Malone, M. Hickey, E. Ha, E. Young, B. Ellingson, C. Kruse, J. Sul, N. Hilf, S. Kutscher, O. Schoor, J. Lindner, C. Reinhardt, T. Kreisl, F. Iwamoto, H. Fine, H. Singh-Jasuja, L. Teijeira, I. Gil-Arnaiz, B. Hernandez-Marin, M. Martinez-Aguillo, S. d. l. C. Sanchez, A. Viudez, I. Hernandez-Garcia, M. J. Lecumberri, R. Grandez, A. F. de Lascoiti, R. V. Garcia, A. Thomas, J. Fisher, U. Baron, S. Olek, H. Rhodes, J. Gui, T. Hampton, L. Tafe, G. Tsongalis, J. Lefferts, H. Wishart, J. Kleen, M. Miller, M. Ernstoff, C. Fadul, G. Vlahovic, K. Peters, T. Ranjan, A. Friedman, H. Friedman, D. Lally-Goss, D. Wainwright, M. Dey, A. Chang, Y. Cheng, Y. Han, M. Lesniak, M. Weller, K. Kaulich, B. Hentschel, J. Felsberg, D. Gramatzki, T. Pietsch, M. Simon, M. Westphal, G. Schackert, J. C. Tonn, M. Loeffler, G. Reifenberger, M. Xu, C. Patil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d36f57a60eb3ecbce1b1d3c649070d
https://europepmc.org/articles/PMC3823893/