Výsledky vyhledávání - "V. O. Sinenko"

Synthesis and evaluation of new thiazole-containing rhodanine-3-alkanoic acids as inhibitors of protein tyrosine phosphatases and glutathione S-transferases

Autor: Vlasyslav Buldenko, Oleksandr L. Kobzar, Yuriy Shulha, Andriy I. Vovk, Diana Hodyna, Stepan G. Pilyo, Volodymyr Brovarets, V. O. Sinenko

Publikováno v: Ukr. Bioorg. Acta 2020, Vol. 15, N2. 15:33-40

Thiazole-containing derivatives of rhodanine-3-alkanoic acids with propanoic or undecanoic acid groups were synthesized and evaluated as inhibitors of some protein tyrosine phosphatases and glutathione S-transferases. The rhodanines bearing longer ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01b0062b1908ac79a68dd308d151ce92
https://doi.org/10.15407/bioorganica2020.02.033

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Hybrid Design of Isonicotinic Acid Hydrazide Derivatives: Machine Learning Studies, Synthesis and Biological Evaluation of their Antituberculosis Activity

Autor: Larysa Metelytsia, Volodymyr Brovarets, Volodymyr Blagodatny, V. O. Sinenko, Ivan V. Semenyuta, Gennady Poda, S. R. Slivchuk, Diana Hodyna, Vasyl Kovalishyn

Publikováno v: Current Drug Discovery Technologies. 17:365-375

Background: Tuberculosis (TB) is an infection disease caused by Mycobacterium tuberculosis (Mtb) bacteria. One of the main causes of mortality from TB is the problem of Mtb resistance to known drugs. Objective: The goal of this work is to identify po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ca54fa40aa40730a0b254037ada067
https://doi.org/10.2174/1570163816666190411110331

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Bioactivity prediction and synthesis of new 3-substituted 5-thiazolylmethylene rhodanines

Autor: Oleksandr L. Kobzar, O.P. Trokhimenko, Vasyl Kovalishyn, O.V. Muzychka, V. O. Sinenko, Diana Hodyna, S. R. Slivchuk

Publikováno v: Reports of the National Academy of Sciences of Ukraine. :70-77

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5943e63a15154b5af6802783d8b3e501
https://doi.org/10.15407/dopovidi2020.05.070

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Rational design of isonicotinic acid hydrazide derivatives with antitubercular activity: Machine learning, molecular docking, synthesis and biological testing

Autor: Gennady Poda, Diana Hodyna, V. O. Sinenko, Larysa Metelytsia, Julie Grouleff, Vasyl Kovalishyn, S. R. Slivchuk, Igor V. Tetko, Ivan V. Semenyuta, Volodymyr Brovarets, Volodymyr Blagodatny

Publikováno v: Chem. Biol. Drug Des. 92, 1272-1278 (2018)

The problem of designing new antitubercular drugs against multiple drug‐resistant tuberculosis (MDR‐TB) was addressed using advanced machine learning methods. As there are only few published measurements against MDR‐TB, we collected a large lit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c52dd2dcf09e83cfc24f0b36c73e63
https://doi.org/10.1111/cbdd.13188

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Lithiation of 2-bromo-4-(1,3-dioxolan-2-yl)-1,3-thiazole

Autor: V. O. Sinenko, Volodymyr Brovarets, S. R. Slivchuk

Publikováno v: Current Chemistry Letters, Vol 7, Iss 1, Pp 1-8 (2018)

The reaction of lithiation of 2-bromo-4-(1,3-dioxolan-2-yl)-1,3-thiazole with in position 5 of the thiazole ring and double lithiation with t-butyllithium (t-BuLi) in positions 2 and 5 lithium diisopropylamide (LDA) are investigated. When lithiated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e83a94093325ac7b15a23e5ea9d881
http://www.growingscience.com/ccl/Vol7/ccl_2018_2.pdf

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Synthesis of New 1,3-Thiazolecarbaldehydes

Autor: V. O. Sinenko, O. P. Mityukhin, Volodymyr Brovarets, S. R. Slivchuk

Publikováno v: Russian Journal of General Chemistry. 87:2766-2775

H-Lithiation and Br-lithiation reactions of 1,3-thiazole were studied in order to obtain new thiazole derivatives. Four isomeric chloromethyl derivatives of 1,3-thiazole containing a protected aldehyde group like 2-(1,3-dioxolan-2-yl)-5-(chloromethyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f3147ac4a596177aaa23b947211fb26
https://doi.org/10.1134/s1070363217120039

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Synthesis of new 1,3-thiazole derivatives from 2(5)-hydroxyalkyl-1,3-thiazole-5(2)-carbaldehydes

Autor: V. O. Sinenko, S. G. Pil’o, S. R. Slivchuk, G. F. Raenko, Volodymyr Brovarets

Publikováno v: Russian Journal of General Chemistry. 86:1597-1603

Reactions of substituted 2-hydroxyalkyl-1,3-thiazole-5-carbaldehydes and 5-hydroxyalkyl-1,3-thiazole-2-carbaldehydes with phenylhydrazine, isoniazid, N-substituted rhodanines were performed as well as Biginelli reaction with acetoacetic ester and ure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e257b03961842c162f40d26561adbb4
https://doi.org/10.1134/s1070363216070100

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Synthesis of 2,5-di(hydroxyalkyl)-1,3-thiazoles

Autor: Ya. G. Bal'on, V. O. Sinenko, Volodymyr Brovarets, S. R. Slivchuk

Publikováno v: Russian Journal of General Chemistry. 85:1855-1861

A general approach towards synthesis of 2(5)-hydroxyalkyl-substituted 1,3-thiazole derivatives has been proposed. The method includes lithiation of 1,3-thiazole ring followed by reacting the formed thiazole lithium derivatives with electrophiles.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b816871519f86c7086a54e534b9749b0
https://doi.org/10.1134/s1070363215080113

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