Proteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased transcriptional-translational activity, keratinocyte-immune crosstalk and disordered axon guidance [version 1; peer review: 2 approved, 1 approved with reservations]

Autor: Martina S. Elias, Sheila C. Wright, William V. Nicholson, Kimberley D. Morrison, Alan R. Prescott, Sara Ten Have, Phillip D. Whitfield, Angus I. Lamond, Sara J. Brown

Publikováno v: Wellcome Open Research, Vol 4 (2019)

Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency l

Externí odkaz: https://doaj.org/article/11969b6df6324a9fab1ed4098282a9b4

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EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Autor: Marek Gierlinski, Sara J. Brown, William V. Nicholson, Angus I. Lamond, Christian Cole, Susan E. Bray, Judit Remenyi, James Abbott, John A. McGrath, Sara ten Have, Sheila C. Wright, Mateusz Glok, Martina S. Elias, Alan R. Prescott, Sharon Edwards, Phillip D. Whitfield, Lavinia Paternoster

Publikováno v: The Journal of Allergy and Clinical Immunology
Elias, M S, Wright, S C, Remenyi, J, Abbott, J C, Bray, S E, Cole, C, Edwards, S, Gierlinski, M, Glok, M, McGrath, J A, Nicholson, W V, Paternoster, L, Prescott, A R, Have, S T, Whitfield, P D, Lamond, A I & Brown, S J 2019, ' EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis ', Journal of Allergy and Clinical Immunology, vol. 144, no. 2, pp. 470-481 . https://doi.org/10.1016/j.jaci.2019.05.024

Background Atopic dermatitis (AD) is a common, complex, and highly heritable inflammatory skin disease. Genome-wide association studies offer opportunities to identify molecular targets for drug development. A risk locus on chromosome 11q13.5 lies be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1412fcdd1c2d74396488c714af4ca1
https://doi.org/10.1016/j.jaci.2019.05.024

Legged locomotion in resistive terrains

Autor: Jonathan E. Clark, John V. Nicholson, Sean Gart, Jason Pusey, Ryan Alicea, Wei Gao

Publikováno v: Bioinspiration & Biomimetics.

The utility, efficiency, and reliability of legged robots has increased dramatically in recent years. Limbed robots are now capable of locomotion across a variety of terrains, however, achieving both rapid and efficient operation when ground conditio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32af30c8f11a8d0117eac097855fb1c
https://doi.org/10.1088/1748-3190/abd011