Zobrazeno 1 - 10
of 165
pro vyhledávání: '"V. Nastase"'
Autor:
Egidia G Miftode, Olivia S Dorneanu, Daniela A Leca, Gabriela Juganariu, Andra Teodor, Mihnea Hurmuzache, Eduard V Nastase, Dana T Anton-Paduraru
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133477 (2015)
Tuberculous meningitis (TBM) is the most lethal form of Mycobacterium tuberculosis infection, which has a high rate of neurological complications and sequelae.Our study offers a real-world infectious disease clinic perspective, being thus representat
Externí odkaz:
https://doaj.org/article/a195a6f4d5124671a65c4ec2dc0594e9
Autor:
Chiara Poluzzi, Jinyang Zeng-Brouwers, Liliana Schaefer, Louise Tzung-Harn Hsieh, Simone Fulda, Kristin Moreth, Malgorzata Wygrecka, Helena Frey, Christian Brandts, Heiko Roedig, Madalina V. Nastase
Publikováno v:
Matrix Biology. 77:4-22
Sterile inflammation is a therapeutic target in many diseases where it represents an important initiator of disease progression. However, the detailed mechanisms underlying its evolution and biological relevance are not yet completely elucidated. Big
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883120acc17cf25a53ba9b86e409127f
https://doi.org/10.1016/j.matbio.2018.05.006
https://doi.org/10.1016/j.matbio.2018.05.006
Publikováno v:
The FEBS Journal. 286:2965-2979
It is well established that biglycan, a small leucine-rich proteoglycan, acts as an extracellular matrix-derived danger signal in its soluble form. By binding to innate immunity Toll-like receptors (TLR) 2 and 4, biglycan initiates and perpetuates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db966939980fba7aea344e6c0b0805e
https://doi.org/10.1111/febs.14791
https://doi.org/10.1111/febs.14791
Akademický článek
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Autor:
Madalina V. Nastase, Janet Beckmann, Louise Tzung Harn Hsieh, Jan Mersmann, Josef Pfeilschifter, Chiara Poluzzi, Liliana Schaefer, Renato V. Iozzo, Jaime Lopez-Mosqueda, Fumiyo Ikeda, Jinyang Zeng-Brouwers, Ivan Dikic, Nina Schroeder, Helena Frey
Publikováno v:
The American Journal of Pathology. 186:1206-1220
Sepsis is burdened by high mortality due to uncontrolled inflammatory response to pathogens. Increased caspase 1 activation causing maturation of IL1β/18 remains a therapeutic challenge in sepsis. SHARPIN (shank-associated regulator of G-protein sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e8c483b3567b3e7f6ea515c8e88d3f
https://doi.org/10.1016/j.ajpath.2015.12.026
https://doi.org/10.1016/j.ajpath.2015.12.026
Autor:
Malgorzata Wygrecka, Charles W. Frevert, Jessica Felgenhauer, Madalina V. Nastase, Liliana Schaefer
Publikováno v:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 66(4)
It is evident that components of the extracellular matrix (ECM) act as danger-associated molecular patterns (DAMPs) through direct interactions with pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) and inflammasomes. Through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37987709d2c7afeed32c442b7aaddbcf
https://pubmed.ncbi.nlm.nih.gov/29290139
https://pubmed.ncbi.nlm.nih.gov/29290139
Autor:
Madalina V. Nastase, Liliana Schaefer, Andrea Janicova, Malgorzata Wygrecka, Louise Tzung-Harn Hsieh, Heiko Roedig
It is now well-established that members of the small leucine-rich proteoglycan (SLRP) family act in their soluble form, released proteolytically from the extracellular matrix (ECM), as danger-associated molecular patterns (DAMPs). By interacting with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8029b347e430f58c639cab9b4697422f
https://europepmc.org/articles/PMC5958374/
https://europepmc.org/articles/PMC5958374/
Autor:
Claudia Tredup, Heinfried H. Radeke, Jinyang Zeng-Brouwers, Janet Beckmann, Urs Christen, Malgorzata Wygrecka, Madalina V. Nastase, Liliana Schaefer
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology.
Th1 and Th17 cells, T helper (Th) subtypes, are key inducers of renal fibrosis. The molecular mechanisms of their recruitment into the kidney, however, are not well understood. Here, we show that biglycan, a proteoglycan of the extracellular matrix,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd68eb8dd8c6395663ba45c590194db
https://pubmed.ncbi.nlm.nih.gov/29253517
https://pubmed.ncbi.nlm.nih.gov/29253517
Publikováno v:
Advanced drug delivery reviews. 129
Renal fibrosis is the common outcome of many chronic kidney diseases (CKD) independent of the underlying etiology. Despite a host of promising experimental data, currently available strategies only ameliorate or delay the progression of CKD but do no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6dcae757849a5d3431a5c0ba8f2b06
https://pubmed.ncbi.nlm.nih.gov/29288033
https://pubmed.ncbi.nlm.nih.gov/29288033
Publikováno v:
Journal of Histochemistry and Cytochemistry
Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule. Proteolytically released from the ECM, big
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0750bbdb92789f5e3f634cda4994e2
https://doi.org/10.1369/0022155412456380
https://doi.org/10.1369/0022155412456380