Zobrazeno 1 - 10
of 423
pro vyhledávání: '"V. N. Charushin"'
Autor:
S. Ya. Loginova, V. N. Schukina, S. V. Savenko, V. V. Rubtsov, S. V. Borisevich, D. L. Chizhov, G. L. Rusinov, E. V. Verbitskiy, V. N. Charushin, S. K. Kotovskaya, V. L. Rusinov
Publikováno v:
Антибиотики и Химиотерапия, Vol 69, Iss 3-4, Pp 21-30 (2024)
Background. The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, originated in Wuhan, China, has claimed millions of lives around the world. In this regard, the search for effective drugs, including the repurposing of existing ones, has becom
Externí odkaz:
https://doaj.org/article/9660279325d74f5aa1e3941ad160ac4b
Autor:
T. D. Moseev, A. F. Khasanov, M. V. Varaksin, D. S. Kopchuk, I. S. Kovalev, O. S. Taniya, M. Rahman, S. Santra, G. V. Zyryanov, O. N. Chupakhin, V. N. Charushin
Publikováno v:
Chimica Techno Acta, Vol 7, Iss 4, Pp 215-221 (2020)
A convenient synthetic approach to meso-substituted with 2,2’-bipyridine and 1-(pyridin-2-yl)isoquinoline residues calix[4]arenes is reported. This approach involves the reaction of generated in situ 2-lithio-calix[4]arene with 1,2,4-triazine precu
Externí odkaz:
https://doaj.org/article/1034844306454201b1fe4c019ae2e580
Autor:
S. YA. Loginova, S. V. Borisevich, B. A. Maksimov, V. P. Bondarev, S. K. Kotovskaya, V. L. Rusinov, V. N. Charushin, O. N. Chupakhin
Publikováno v:
Антибиотики и Химиотерапия, Vol 55, Iss 9-10, Pp 25-28 (2020)
The experimental study of the prophylactic efficacy of Triazaverin against the experimental form of the influenza virus A (H5N1) on albino mice intranasally infected with the influenza virus A/Chicken/Kurgan/Russia/02/05 vs. the reference drugs Tamif
Externí odkaz:
https://doaj.org/article/2f9d299f484345cb9353cf64de3cf8d0
Autor:
S. YA. Loginova, S. V. Borisevich, V. L. Rusinov, U. N. Ulomsky, V. N. Charushin, O. N. Chupakhin
Publikováno v:
Антибиотики и Химиотерапия, Vol 57, Iss 11-12, Pp 8-10 (2020)
The study of the toxicity of triazavirin, a new antiinfluenza agent, showed that the maximum concentration of the drug, inducing no microscopically visible changes in the structure of the monolayer and the cells of the MDCK and SKEV cell cultures, wa
Externí odkaz:
https://doaj.org/article/b0a8c0dbd0ba4d2aaf0db9ca0dce9fef
Autor:
S. YA. Loginova, S. V. Borisevich, V. L. Rusinov, U. N. Ulomsky, V. N. Charushin, O. N. Chupakhin
Publikováno v:
Антибиотики и Химиотерапия, Vol 59, Iss 1-2, Pp 3-5 (2020)
The efficacy of Triazavirin against the tick-borne encephalitis virus was estimated in the sensitive cell culture vs. the active drug Ribavirin®. In a concentration of 128 mcg/ml Triazavirin was shown active in inhibition of the tick-borne encephali
Externí odkaz:
https://doaj.org/article/f9fd1c491fd54c768955a0d09bb0a47e
Autor:
S. Ya. Loginova, S. V. Borisevich, V. L. Rusinov, E. N. Ulomsky, V. N. Charushin, O. N. Chupakhin, P. V. Sorokin
Publikováno v:
Антибиотики и Химиотерапия, Vol 60, Iss 7-8, Pp 11-13 (2020)
The comparative study of the therapeutic efficacy of Triazavirin against experimental Forest-Spring encephalitis on albino mice vs. the active drug Ribavirin® showed that in high doses (200-400 mg/kg) Triazavirin moderately protected the infected an
Externí odkaz:
https://doaj.org/article/33038a5f7a00440da31f4619b00ec503
Autor:
A. V. Baklykov, A. A. Tumashov, S. K. Kotovskaya, E. N. Ulomskiy, G. L. Rusinov, V. L. Rusinov, D. S. Kopchuk, O. N. Chupakhin, V. N. Charushin
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 4, Pp 98-102 (2019)
A procedure for the simantenous determination of aminotriazole, triazolopyrimidinone and nirotriazolopyrimidinone was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a colu
Externí odkaz:
https://doaj.org/article/1fa4287d9c6241f3b8f27892ed268400
Autor:
A. V. Baklykov, A. A. Tumashov, S. K. Kotovskaya, E. N. Ulomskiy, G. L. Rusinov, V. L. Rusinov, O. N. Chupahin, V. N. Charushin
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 2, Pp 146-150 (2019)
Method of simultaneous determination of aminotriazole and triazolopyrimidinone using HPLC with UV-detection was developed. For best chromatographic performance Zorbax NH2 amino phase column (Agilent Technologies, USA) was selected. The applicability
Externí odkaz:
https://doaj.org/article/492edb3153cc409bb1a211790a3ca486
Autor:
E. G. Deyeva, Yu. I. Shevchik, A. A. Shaldghan, K. A. Zagorodnikova, A. A. Tumashov, A. V. Baklykov, S. K. Kotovskaya, O. N. Chupahin, V. N. Charushin, V. L. Rusinov, D. S. Kopchuk
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 3, Pp 172-180 (2019)
The paper contains а results of the study of the pharmacokinetics, tolerability and safety of a new influenza drug Triazide in several dose regimens conducted on healthy volunteers. The convenient method for the determining the Triazide in blood pla
Externí odkaz:
https://doaj.org/article/40894e12a0b44763b2c48a47d8af313f
Autor:
A. V. Baklykov, A. A. Tumashov, S. K. Kotovskaya, E. N. Ulomsky, G. L. Rusinov, V. L. Rusinov, G. A. Artem’ev, D. S. Kopchuk, V. N. Charushin
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 2, Pp 78-83 (2019)
A procedure for quantitative determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l -argininy was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a col
Externí odkaz:
https://doaj.org/article/ebf6dce434b24def95aa312d1ae2d3b3