Zobrazeno 1 - 6
of 6
pro vyhledávání: '"V. N. Baykova"'
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 48-53 (2020)
In children oncology high doses of methotrexate (HD Mtx) use for treatment of osteosarcoma, acute lymphoblastic leukemia and many others tumors. Due to high intra- and interindividual Mtx pharmacokinetic variability it is essential perform monitoring
Externí odkaz:
https://doaj.org/article/456d745a65a149bcad6817afc6e985c8
Publikováno v:
Успехи молекулярной онкологии, Vol 2, Iss 1, Pp 082-089 (2015)
Methotrexate (Mtx) is a cytotoxic drug from the group of antimetabolites, folic acid antagonists. High-dose (HD) Mtx in pediatric oncology are used for the treatment of osteosarcoma (OS), and other types of tumors. This therapy has allowed to achieve
Externí odkaz:
https://doaj.org/article/8fab9aa7a80b4812b1fef5b9c115a7f7
Autor:
M. M. Dobrovolskaya, V N Baykova, E. G. Gorozhanskaya, G. N. Zubrikhina, S. P. Sviridova, A V Sitov
Publikováno v:
Biomeditsinskaya Khimiya. 61:519-525
To determine the biochemical disorders in the blood coagulation mechanism associated with oxidative stress parameters of the antioxidant status were examined in platelets of 57 colorectal cancer patients, (including 21 patients before and after surge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2767b47b4f53b83647981719ec9500
https://doi.org/10.18097/pbmc20156104519
https://doi.org/10.18097/pbmc20156104519
Publikováno v:
RUDN Journal of Medicine, Vol 0, Iss 3, Pp 10-13 (2008)
Methotrexate is one of the most effective and widely used cytostatic drugs. However as all antineoplastic drugs it has very low therapeutic index and high toxicity. Kinetic parameters (rate constants, half-times of restoration and extreme values of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::fe3bfc5c82218dc19bb66194cce60a3e
http://journals.rudn.ru/medicine/article/view/3647
http://journals.rudn.ru/medicine/article/view/3647
Publikováno v:
Patologicheskaia fiziologiia i eksperimental'naia terapiia. (2)
High-dose methotrexate blocks the metabolic pathways of conversion of homocysteine to methionine. As a result, homocysteine (hcy) accumulates in the blood. The aim of this study was to determine the relationship between changes in concentrations of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b18ee107970be7f9c3b8ebd90ff6f643
https://pubmed.ncbi.nlm.nih.gov/25318162
https://pubmed.ncbi.nlm.nih.gov/25318162
Publikováno v:
Современная онкология, Vol 3, Iss 1, Pp 13-16 (2001)
Воздействие на процессы регуляции пролиферации и передачи митогенного сигнала в опухолевых клетках является в настоящее время новым п
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::484fca994446022b26459642ccf460ab
https://modernonco.orscience.ru/1815-1434/article/view/26389
https://modernonco.orscience.ru/1815-1434/article/view/26389