Výsledky vyhledávání - "V. N. Balaji"

GSK3β: A master switch and a promising target

Autor: Samiron Phukan, Akanksha Kannoji, V. N. Balaji, V Sudher Babu

Publikováno v: Expert Opinion on Therapeutic Targets. 12:1443-1455

Background: Glycogen synthase kinase 3 beta (GSK3β) is a multifunctional serine/threonine kinase, which plays a major role in various signaling pathways. More than two decades after its discovery, various pharmaceutical companies are focusing on thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e860c9339225289abbeadc6729fd5d31
https://doi.org/10.1517/14728222.12.11.1443

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Pose Prediction Accuracy in Docking Studies and Enrichment of Actives in the Active Site of GSK-3β

Autor: Pravin Kumar Gadakar, V. N. Balaji, Samiron Phukan, Prasanna Dattatreya

Publikováno v: Journal of Chemical Information and Modeling. 47:1446-1459

We present molecular docking studies on the inhibitors of GSK-3beta kinase in the enzyme binding sites of the X-ray complexes (1H8F, 1PYX, 1O9U, 1Q4L, 1Q5K, and 1UV5) using the Schrödinger docking tool Glide. Cognate and cross-docking studies using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6862ec3212d6b3ac37f5d356782c2df0
https://doi.org/10.1021/ci6005036

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Conformations of Model Peptides With 1-Aminocycloalkane-1-Carboxylic Acid Residues

Autor: Shashidhar N. Rao, K. Ramnarayan, Ming Fai Chan, V. N. Balaji

Publikováno v: Protein & Peptide Letters. 3:31-38

Abstract: We present conformational energy calculations on model compounds contammg 1-amino cycloalkane carboxylic acid with 5- (Acc5 )and 6- (Acc6) membered rings using molecular mechanics methods. The low energy models adopt conformations charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64620abff1176ffe88fd9ba4999c7524
https://doi.org/10.2174/092986650301220608154039

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Theoretical Studies on 1-Acetylamino-N-2,3,4,5-Pentamethyl- 2,4-Cyclopentadiene-1-Carboxarnide

Autor: Shashidhar N. Rao, K. Ramnarayan, Ming Fai Chan, V. N. Balaji

Publikováno v: Protein & Peptide Letters. 1:141-148

We present molecular mechanics conformational energy calculations on the model dipeptide 1- acetylamino-N-2,3,4,5-pentamethyl-2,4-cyclopentadiene-1-carboxarnide (1). The salient results are expressed as plots drawn as a function of the backbone torsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a06bf26a444ca4142fef17f9f9187ccc
https://doi.org/10.2174/0929866501666220424232046

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Identification of an extracytoplasmic region of H+,K(+)-ATPase labeled by a K(+)-competitive photoaffinity inhibitor

Autor: K. Munson, Gary S. Sachs, C Gutierrez, V N Balaji, K Ramnarayan

Publikováno v: Journal of Biological Chemistry. 266:18976-18988

The photoaffinity reagent 8-[(4-azidophenyl)-methoxy]-1-tritiomethyl-2, 3-dimethylimidazo-[1,2-alpha]pyridinium iodide ([3H]mDAZIP) has been synthesized and used to photoinactivate and label purified hog gastric H+,K(+)-ATPase. The specific (K(+)-sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9812940c2dfad1e1538a62c0c7552e4
https://doi.org/10.1016/s0021-9258(18)55159-0

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Changing profile of prostatic abscess

Autor: Suresh K. Bhagat, Mary S. Mathews, Ganesh Gopalakrishnan, V N Balaji, Nitin S Kekre

Publikováno v: International braz j urol, Volume: 34, Issue: 2, Pages: 164-170, Published: MAR 2008
International braz j urol v.34 n.2 2008
International Braz J Urol
Sociedade Brasileira de Urologia (SBU)
instacron:SBU
International Brazilian Journal of Urology, Vol 34, Iss 2, Pp 164-170 (2008)

PURPOSE: To compare the clinical presentation of prostatic abscess and treatment outcome in two different time frames with regards to etiologies, co-morbid factors and the impact of multidrug resistant organism. MATERIALS AND METHODS: We retrospectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89f336dbae68d2ce65462e329c37ad7
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382008000200006&lng=en&tlng=en

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Glu-96 of basic fibroblast growth factor is essential for high affinity receptor binding. Identification by structure-based site-directed mutagenesis

Autor: H, Zhu, K, Ramnarayan, J, Anchin, W Y, Miao, A, Sereno, L, Millman, J, Zheng, V N, Balaji, M E, Wolff

Publikováno v: The Journal of biological chemistry. 270(37)

The importance of basic fibroblast growth factor (bFGF) in several pathophysiological processes has stimulated interest in the design of receptor antagonists to mitigate such effects. Of key importance in this connection is the characterization of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa34f884f5e8ca0b56472e926b7e3485
https://pubmed.ncbi.nlm.nih.gov/7665610

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Characterization of a linear pentapeptide containing two consecutive beta-turns

Autor: K, Ramnarayan, V N, Balaji, K I, Varughese

Publikováno v: Peptide research. 7(5)

The contiguous occurrence of two beta-turns is examined using molecular mechanics calculations. A tripeptide can take up special conformations known as beta-turns resulting in the reversal of the chain. There are two major classes of beta-turns, call

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2fbe817fcfbc45b96a92b659865e7adb
https://pubmed.ncbi.nlm.nih.gov/7849421

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Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening

Autor: E. Hwang, I. Okun, Ming Fai Chan, F. L. Stavros, M. E. Wolff, V. N. Balaji

Publikováno v: Biochemical and biophysical research communications. 201(1)

Novel endothelin antagonists were identified through a "pharmacophore directed screening" strategy. The sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00f959715a7820f064ae865198495c5
https://pubmed.ncbi.nlm.nih.gov/8198578

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Conformational studies on model peptides with 1-aminocyclopropane 1-carboxylic acid residues

Autor: V N, Balaji, K, Ramnarayan, M F, Chan, S N, Rao

Publikováno v: Peptide research. 7(2)

The design of metabolically stable, conformationally constrained peptidomimetics is an increasingly used approach in developing orally active drug candidates in pharmaceutical research. In this paper we present conformational energy calculations on m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89833aa3838f0c1c32162dfb11b65182
https://pubmed.ncbi.nlm.nih.gov/8012122

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