Výsledky vyhledávání - "V. N. Babakov"

The role of cytochromes CYP1A and CYP3A in the genotoxic effect of benzo(a)pyrene

Autor: Daria Alexandrovna Malygina, Nadezhda Yurievna Rogovskaya, Petr Petrovich Beltyukov, V. N. Babakov

Publikováno v: Toxicological Review. 30:158-166

Introduction. Benzo(a)pyrene metabolites are genotoxic compounds, the accumulation of which contributes to carcinogenesis. The main mechanism of metabolite formation is the benzo(a)pyrene oxidation by cytochromes P450 (CYP). Inhibitors of the main cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7effa6ee4476d3b32adf75a7a836d07b
https://doi.org/10.47470/0869-7922-2022-30-3-158-166

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TiO2-modified MALDI target for in vitro modeling of the oxidative biotransformation of diclofenac

Autor: Konstantin A. Krasnov, V. N. Babakov, Ekaterina P. Podolskaya, Alexander Yu. Gorbunov, O. A. Keltsieva, Alexander A. Bardin

Publikováno v: Mendeleev Communications. 30:220-222

The UV-induced photocatalytic oxidation in the presence of TiO2 nanoparticles (UV/TiO2-PCO) is a more adequate approach than electrochemical oxidation to simulate the oxidative metabolism of diclofenac based on the comparative analysis of oxidation p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d93754a38abff99a65f260b5ec9dac5b
https://doi.org/10.1016/j.mencom.2020.03.030

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Mass spectrometry based proteomic approach for the screening of butyrylcholinesterase adduct formation with organophosphates

Autor: Olga Chuprina, Nikolay Solovyev, V. N. Babakov, Andrey S. Radilov, Yaroslav A. Dubrovskii, Petr Bel'tyukov, Ekaterina A. Murashko

Publikováno v: Talanta. 197:374-382

Organophosphates’ toxic effect causes covalent binding to serine-198 in the active site of human plasma butyrylcholinesterase (BChE) with loss of enzymatic function (covalent inhibition). Mass spectrometric detection of modified FGESAGAAS peptide a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1624e936ce18aa87fb2fc902637c34e1
https://doi.org/10.1016/j.talanta.2019.01.059

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Collapsed monomolecular thin films as surface nanomodification techniques for bioorganic MALDI analysis

Autor: P. S. Dubakova, Vladimir V. Shilovskikh, N. V. Krasnov, O. A. Keltsieva, P. A. Oleneva, M. L. Alexandrova, A. A. Mitrofanov, Artem A. Selyutin, Ekaterina P. Podolskaya, Elena S. Silyavka, Nikolai G. Sukhodolov, V. N. Babakov

Publikováno v: AIP Conference Proceedings.

A modification method of the target for Matrix Assisted Laser Desorption/Ionization (MALDI) analysis by metal-affinity sorbents was proposed. Monolayers of metal stearates obtained in the geometry of the drop perform as such sorbents. The formation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17913329e5dd340bfb77dd1613aa1ebb
https://doi.org/10.1063/1.5087677

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Determination of protein adducts of organophosphorus nerve agents in blood plasma

Autor: A. S. Radilov, N. S. Khlebnikova, E. I. Savel’eva, G. V. Karakashev, E. A. Murashko, V. N. Babakov, Ya. A. Dubrovskii, A. I. Ukolov, V. Yu. Koneva, V. A. Kopeikin, E. S. Ukolova, N. L. Koryagina

Publikováno v: Journal of Analytical Chemistry. 71:849-859

A comparative study of the efficiency of procedures for the determination of the biomarkers of organophosphorus agents (OPAs) in blood plasma was performed. It was found that the gas chromatography–mass spectrometry determination of OPAs reactivate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::689827621711eb9ca720d5f0dd204d6e
https://doi.org/10.1134/s1061934816080086

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Application of lanthanum stearate monolayers as a metal-affinity sorbent for the selective sorption of soman adducts to human serum albumin

Autor: Vladimir V. Shilovskikh, Artem A. Selyutin, E. V. Shreiner, V. N. Babakov, Ekaterina P. Podolskaya, Yaroslav A. Dubrovskii, O. A. Keltsieva, I.G. Zenkevich, Ivan M. Zorin, Nikolai G. Sukhodolov

Publikováno v: Talanta. 195

A new metal-affinity sorbent based on lanthanum stearate monolayers has been developed and characterized. The prospect of its application to specific extraction of organophosphorous compound (OP) adducts of blood proteins was demonstrated. For this,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bdbc94e409563c8fcdaad318c10c9c
https://pubmed.ncbi.nlm.nih.gov/30625608

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Genotyping single-nucleotide polymorphisms of human genes involved in organophosphate detoxification by high-resolution melting

Autor: V. N. Babakov, Ivan Kurdyukov, Gennady Rodionov, Andrey S. Radilov

Publikováno v: Analytical and Bioanalytical Chemistry. 406:5087-5092

Paraoxonase-1 (PON1) and butyrylcholinesterase (BCHE) are natural bioscavengers of organophosphate acetylcholinesterase inhibitors in the human body, which can determine individual sensitivity to organophosphate toxicity. Interindividual differences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e846e76788fa4b885ae88858e81e5d18
https://doi.org/10.1007/s00216-014-7734-7

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Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase

Autor: Ekaterina P. Podolskaya, Florian Nachon, John Mikler, Patrick Masson, Wei Jiang, Yaroslav A. Dubrovskii, Oksana Lockridge, Lawrence M. Schopfer, V. N. Babakov, Ekaterina A. Murashko

Publikováno v: Analytical Biochemistry. 439:132-141

Exposure to nerve agents or organophosphorus (OP) pesticides can have life-threatening effects. Human plasma butyrylcholinesterase (BChE) inactivates these poisons by binding them to Ser198. After hours or days, these OP adducts acquire a negative ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f41336cbe4dfc3af166031055a76b4
https://doi.org/10.1016/j.ab.2013.04.018

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Study of sorption of platinum and palladium cyanometallate complexes as the key to understanding the mechanism of binding the [Au(CN)2]− anion with carbon adsorbents

Autor: R. I. Ibragimova, D. A. Pichugina, V. N. Babakov, Ya. A. Dubrovskii, Vasily V. Kaichev, N. V. Vorob’ev-Desyatovskii, S. A. Kubyshkin

Publikováno v: Russian Journal of General Chemistry. 82:384-397

Goldcarb WSC-207C GR activated carbons with platinum and palladium complexes adsorbed from aqueous solutions of K2[Pt(CN)4], K2[Pt(CN)6], and K2[Pd(CN)4] were studied by the methods of X-ray photoelectron spectroscopy and IR spectroscopy with Fourier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c9bdf94f9f067a912dca3b7a9d8474e
https://doi.org/10.1134/s107036321203005x

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