Zobrazeno 1 - 10
of 120
pro vyhledávání: '"V. Nüssler"'
Autor:
V. Nüssler, M Darsow, A Pogrebniak, M Scholz, O J Stoetzer, R. Pelka-Fleischer, E. Gullis, Wolfgang Wilmanns
Publikováno v:
Leukemia. 13:1873-1880
Glucocorticoids and fludarabine are able to induce typical features of apoptosis in CLL lymphocytes. Cysteinyl aspartate specific proteases (caspases) play a key biochemical role in the apoptotic pathway. Caspase activation following cytotoxic stimul
Autor:
W. Abenhardt, Wolfgang Wilmanns, H. Zwierzina, E. Gullis, V. Nüssler, R. Schmitt, A. Wohlrab, Kolb Hj, I. Langenmayer, Frank Gieseler, H. Diem, R. Pelka-Fleischer
Publikováno v:
Annals of Hematology. 74:57-64
The aim of the study was to test whether fractionated (weekly) idarubicin administration to multiply pretreated leukemia patients is effective and tolerable for outpatient treatment, and whether idarubicin alone can overcome P-glycoprotein (P-gp)-rel
Publikováno v:
Annals of Hematology. 69:S13-S17
In order to interact with topoisomerase II and induce genotoxicity, anthracyclines have to cross the outer cell membrane and the cytoplasm, enter the nucleus, and bind to the DNA. We incubated sensitive and resistant hematopoietic cells from cell lin
Publikováno v:
Oncology Research and Treatment. 17:428-432
Background: In lymphoproliferative disorders serum β2-microglobulin (β2m) can be useful as a clinical marker. Material and Methods: β2m measurements were carried out with a new assay of Hoffmann-La Roche, which is a one-step solid-phase enzyme imm
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Autor:
C. Teale, N. Bosanquet, M. von Euler, D. Newling, Lothar Bergmann, B. Jonsson, V. Nüssler, B. Paschen, Christopher McCabe, Marianne J. Ellis, Nils Wilking, Harald Enzmann, R. de Wilde, K.-J. Kallen, Heinz Zwierzina
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 20(3)
To air challenging issues related to patient and market access to new anticancer agents, the Biotherapy Development Association--an international group focused on developing targeted cancer therapies using biological agents--convened a meeting on 29
Publikováno v:
European journal of medical research. 11(8)
FK866 is a novel anticancer agent that was previously shown to interfere with NAD superset+ biosynthesis by inhibition of nicotinamide phosphoribosyltransferase and to initiate apoptosis in cancer cells. As NAD superset+ is involved in cellular DNA r
Publikováno v:
European journal of medical research. 8(10)
Polyadenosylation of nuclear enzymes is well known to regulate the cellular repair capacity after DNA damage. PARP mediates the transfer of poly-ADP-ribose moieties on itself and other nuclear proteins by the breakdown of NAD+. The present study inve