Zobrazeno 1 - 10
of 545
pro vyhledávání: '"V. Mosharov"'
Autor:
Hye Sung Kim, Yang Xiao, Xuejing Chen, Siyu He, Jongwon Im, Moshe J. Willner, Michael O. Finlayson, Cong Xu, Huixiang Zhu, Se Joon Choi, Eugene V. Mosharov, Hae‐Won Kim, Bin Xu, Kam W. Leong
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract Understanding the impact of long‐term opioid exposure on the embryonic brain is critical due to the surging number of pregnant mothers with opioid dependency. However, this has been limited by human brain inaccessibility and cross‐specie
Externí odkaz:
https://doaj.org/article/b46900ca4b6748a09f94984845285e8f
Autor:
Ayelet M. Rosenberg, Manish Saggar, Anna S. Monzel, Jack Devine, Peter Rogu, Aaron Limoges, Alex Junker, Carmen Sandi, Eugene V. Mosharov, Dani Dumitriu, Christoph Anacker, Martin Picard
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The brain and behavior are under energetic constraints, limited by mitochondrial energy transformation capacity. However, the mitochondria-behavior relationship has not been systematically studied at a brain-wide scale. Here we examined the
Externí odkaz:
https://doaj.org/article/941e18427e5a4b75b3dce7e14eca5d2e
Autor:
Nagendran Ramalingam, Shan-Xue Jin, Tim E. Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P. Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V. Mosharov, Weisheng V. Chen, Shaomin Li, Dennis J. Selkoe, Ulf Dettmer
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the physiological role for pS129 has remained undefined. Here we use mult
Externí odkaz:
https://doaj.org/article/d183b6fc70b54d8f9e89896f83034181
Autor:
Rachel M. Wise, Annika Wagener, Urban M. Fietzek, Thomas Klopstock, Eugene V. Mosharov, Fabio A. Zucca, David Sulzer, Luigi Zecca, Lena F. Burbulla
Publikováno v:
Neurobiology of Disease, Vol 175, Iss , Pp 105920- (2022)
Dopamine metabolism, alpha-synuclein pathology, and iron homeostasis have all been implicated as potential contributors to the unique vulnerability of substantia nigra dopaminergic neurons which preferentially decline in Parkinson's disease and some
Externí odkaz:
https://doaj.org/article/e6f361bf364946ad96e2c80a8b58ac4d
Autor:
Benjamin D Hobson, Se Joon Choi, Eugene V Mosharov, Rajesh K Soni, David Sulzer, Peter A Sims
Publikováno v:
eLife, Vol 11 (2022)
Dopaminergic neurons modulate neural circuits and behaviors via dopamine (DA) release from expansive, long range axonal projections. The elaborate cytoarchitecture of these neurons is embedded within complex brain tissue, making it difficult to acces
Externí odkaz:
https://doaj.org/article/a01d529b993f4d78b3792e7846a9dfbb
Autor:
Benjamin D. Hobson, Adrien T. Stanley, Mark B. De Los Santos, Bruce Culbertson, Eugene V. Mosharov, Peter A. Sims, David Sulzer
Publikováno v:
Brain, Behavior, and Immunity. 111:277-291
Dysregulated inflammation within the central nervous system (CNS) contributes to neuropathology in infectious, autoimmune, and neurodegenerative disease. With the exception of microglia, major histocompatibility complex (MHC) proteins are virtually u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5e7e4afc770d57b3a7cfb2abc8e896
https://doi.org/10.1016/j.bbi.2023.04.008
https://doi.org/10.1016/j.bbi.2023.04.008
Autor:
Ayelet M Rosenberg, Shannon Rausser, Junting Ren, Eugene V Mosharov, Gabriel Sturm, R Todd Ogden, Purvi Patel, Rajesh Kumar Soni, Clay Lacefield, Desmond J Tobin, Ralf Paus, Martin Picard
Publikováno v:
eLife, Vol 10 (2021)
Background: Hair greying is a hallmark of aging generally believed to be irreversible and linked to psychological stress. Methods: Here, we develop an approach to profile hair pigmentation patterns (HPPs) along individual human hair shafts, producing
Externí odkaz:
https://doaj.org/article/35d0dd96c5ff465ebd75a8acc8547e1f
Autor:
Se Joon Choi, Thong C Ma, Yunmin Ding, Timothy Cheung, Neal Joshi, David Sulzer, Eugene V Mosharov, Un Jung Kang
Publikováno v:
eLife, Vol 9 (2020)
Changes in striatal cholinergic interneuron (ChI) activity are thought to contribute to Parkinson’s disease pathophysiology and dyskinesia from chronic L-3,4-dihydroxyphenylalanine (L-DOPA) treatment, but the physiological basis of these changes is
Externí odkaz:
https://doaj.org/article/9de2cfb5aac448b48256d15788c3c5f3
Autor:
Sun Young Chung, Sarah Kishinevsky, Joseph R. Mazzulli, John Graziotto, Ana Mrejeru, Eugene V. Mosharov, Lesly Puspita, Parvin Valiulahi, David Sulzer, Teresa A. Milner, Tony Taldone, Dimitri Krainc, Lorenz Studer, Jae-won Shim
Publikováno v:
Stem Cell Reports, Vol 7, Iss 4, Pp 664-677 (2016)
Parkinson's disease (PD) is characterized by the selective loss of dopamine neurons in the substantia nigra; however, the mechanism of neurodegeneration in PD remains unclear. A subset of familial PD is linked to mutations in PARK2 and PINK1, which l
Externí odkaz:
https://doaj.org/article/a501ca37f14940beb9ce6026a56a7725
Autor:
Zachary Freyberg, Mark S. Sonders, Jenny I. Aguilar, Takato Hiranita, Caline S. Karam, Jorge Flores, Andrea B. Pizzo, Yuchao Zhang, Zachary J. Farino, Audrey Chen, Ciara A. Martin, Theresa A. Kopajtic, Hao Fei, Gang Hu, Yi-Ying Lin, Eugene V. Mosharov, Brian D. McCabe, Robin Freyberg, Kandatege Wimalasena, Ling-Wei Hsin, Dalibor Sames, David E. Krantz, Jonathan L. Katz, David Sulzer, Jonathan A. Javitch
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Amphetamines are known to enhance extracellular dopamine levels, but the underlying mechanisms are unclear. Utilising a new pH biosensor for synaptic vesicles, the authors show that amphetamines diminish vesicle pH gradients, disrupting dopamine pack
Externí odkaz:
https://doaj.org/article/3b8bfbbdbb454af19a8c38df694cd7dd