Zobrazeno 1 - 10
of 290
pro vyhledávání: '"V. McDermott"'
Publikováno v:
Frontiers in Pain Research, Vol 2 (2021)
Chronic pain is a growing public health crisis that requires exigent and efficacious therapeutics. GPR171 is a promising therapeutic target that is widely expressed through the brain, including within the descending pain modulatory regions. Here, we
Externí odkaz:
https://doaj.org/article/6497a00d175e43b2bba21d47336fff1e
GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice
Publikováno v:
Behavioural pharmacology. 33(7)
A newly deorphanized G protein-coupled receptor, GPR171, is found to be highly expressed within the periaqueductal gray, a pain-modulating region in the brain. Our recent research has shown that a GPR171 agonist increases morphine antinociception in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da12bf564834d823afb9e9e7685ff00e
https://pubmed.ncbi.nlm.nih.gov/35942845
https://pubmed.ncbi.nlm.nih.gov/35942845
Autor:
Drew V. McDermott
An exploration of the mind-body problem from the perspective of artificial intelligence.In Mind and Mechanism, Drew McDermott takes a computational approach to the mind-body problem (how it is that a purely physical entity, the brain, can have experi
Akademický článek
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Autor:
Max V. McDermott, Akila Ram, Matt T. Mattoon, Emmaline E. Haderlie, Megan C. Raddatz, Madi K. Thomason, Erin N. Bobeck
Publikováno v:
Pharmacology Biochemistry and Behavior. 224:173543
ProSAAS is one of the most abundant proteins in the brain and is processed into several smaller peptides. One of which, BigLEN, is an endogenous ligand for the G protein-coupled receptor, GPR171. Recent work in rodent models has shown that a small-mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aacbeaa52e8f0f09302aa9934ed1d53
https://doi.org/10.1016/j.pbb.2023.173543
https://doi.org/10.1016/j.pbb.2023.173543
Publikováno v:
J Pharmacol Exp Ther
ProSAAS is one of the most widely expressed proteins throughout the brain and was recently found to be upregulated in chronic fibromyalgia patients. BigLEN is a neuropeptide that is derived from ProSAAS and was recently discovered to be the endogenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132644ba59b6d252c2106963b9f4492f
https://doi.org/10.1124/jpet.119.259242
https://doi.org/10.1124/jpet.119.259242
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d4dee1c84f6e3c04e7751fcfccd13f
https://doi.org/10.1096/fasebj.2021.35.s1.03935
https://doi.org/10.1096/fasebj.2021.35.s1.03935
Autor:
Max V. McDermott, Erin N. Bobeck
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e755b406bc7ad8ef67861a1b2b33e33
https://doi.org/10.1096/fasebj.2021.35.s1.04492
https://doi.org/10.1096/fasebj.2021.35.s1.04492
Chronic pain is a growing public health crisis that requires exigent and efficacious therapeutics. GPR171 is a promising therapeutic target that is widely expressed through the brain, including within the descending pain modulatory regions. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50d18bc14cfa8ef43a2bfd3a5bd75768
https://doi.org/10.1101/2021.04.16.440030
https://doi.org/10.1101/2021.04.16.440030
Publikováno v:
Mayo Clinic Proceedings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559d058e3b6e18ebe21f27e8ae6ef194
http://europepmc.org/articles/PMC7834637
http://europepmc.org/articles/PMC7834637