Zobrazeno 1 - 10
of 95
pro vyhledávání: '"V. Magedov"'
Autor:
Alexander Kornienko, Snezna Rogelj, Anna Andolfi, Stephen C. Pelly, Véronique Mathieu, Robert Kiss, Robert Johnston, Willem A. L. van Otterlo, Igor V. Magedov, Florence Lefranc, Delphine Lamoral-Theys, Mary R. Reisenauer, Kathryn Hayden, Cody Champion, Giovanni Luchetti, Antonio Evidente
Publikováno v:
ChemMedChem. 7:815-822
The Amaryllidaceae alkaloid bulbispermine was derivatized to produce a small group of synthetic analogues. These, together with bulbispermine's natural crinine-type congeners, were evaluated in vitro against a panel of cancer cell lines with various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263e0f4c6960cb77d1d3c8e81bdc1cbe
https://doi.org/10.1002/cmdc.201100608
https://doi.org/10.1002/cmdc.201100608
Autor:
Madhuri Manpadi, Mikhail Yu. Antipin, Paul Tongwa, Jeff Altig, Willem A. L. van Otterlo, Antonio Evidente, Artem S. Kireev, Igor V. Magedov, Alexander Kornienko
Publikováno v:
The Journal of Organic Chemistry. 74:7122-7131
Pancratistatin is a phenanthridone-type natural product isolated from several plants of the Amaryllidaceae family. Its potent antiproliferative, antivascular, antiviral, and antiparasitic properties have attracted the attention of synthetic, biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72aef48aadcbc6ba629962ba0ca5768
https://doi.org/10.1021/jo901494r
https://doi.org/10.1021/jo901494r
Autor:
Alexander A. Mikhalin, Snezna Rogelj, Michaelann Tartis, Alexander Kornienko, Nikolai M. Evdokimov, Igor V. Magedov, Liliya V. Frolova, Robert Johnston
Publikováno v:
Journal of Liposome Research. 25:232-260
Dihydropyridopyrazoles are simplified synthetic analogues of podophyllotoxin that can effectively mimic its molecular scaffold and act as potent mitotic spindle poisons in dividing cancer cells. However, despite nanomolar potencies and ease of synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f548afb8e43eae407039ef7a7aee5f10
https://doi.org/10.3109/08982104.2014.992022
https://doi.org/10.3109/08982104.2014.992022
Autor:
Nikolai M. Evdokimov, Snezna Rogelj, Anntherese E. Romero, Charles B. Shuster, Laetitia Moreno Y Banuls, Tania Betancourt, Isaiah Otero, Kathryn Hayden, Ernest Hamel, Shi-Long Lu, Igor V. Magedov, Liliya V. Frolova, Alexander Kornienko, Shiva K. Rastogi, Ross W.R. Smith, Robert Kiss, Menuka Karki
Publikováno v:
Journal of Medicinal Chemistry. 56:6886-6900
We developed synthetic chemistry to access the marine alkaloid rigidins and over 40 synthetic analogues based on the 7-deazaxanthine, 7-deazaadenine, 7-deazapurine, and 7-deazahypoxanthine skeletons. Analogues based on the 7-deazahypoxanthine skeleto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48139312ed364bfc3d418a76d8d1a50b
https://doi.org/10.1021/jm400711t
https://doi.org/10.1021/jm400711t
Autor:
Laetitia Moreno Y Banuls, Véronique Mathieu, Snezna Rogelj, Igor V. Magedov, Robert Kiss, Liliya V. Frolova, Alexander Kornienko, Amanda S. Peretti, Florence Lefranc
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3277-3282
Many types of cancer, including glioma, melanoma, NSCLC, among others, are resistant to apoptosis induction and poorly responsive to current therapies with propaptotic agents. We describe a series of 2,3-disubstituted indoles, which display cytostati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a027cb3e8d1638bd5cd9d13d9cb7120
https://doi.org/10.1016/j.bmcl.2013.03.110
https://doi.org/10.1016/j.bmcl.2013.03.110
Autor:
Liliya V. Frolova, Snezna Rogelj, Aidar T. Gubaidullin, Indranil Malik, Elena V. Platova, Nikki Porch, Elvira S. Batyeva, Oleg G. Sinyashin, Leslie Edwards, Igor V. Magedov, E. K. Badeeva
Publikováno v:
Heteroatom Chemistry. 24:163-167
A new reaction of white phosphorus (P4) with elemental sulfur and thiols in the presence of different amines has been investigated. Ammonium salts of S,S′-dialkyltetrathiophosphoric acids have been observed as main products of the reaction. Octathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f63efcfa327083b2d7f8c6f0ccc9adb
https://doi.org/10.1002/hc.21077
https://doi.org/10.1002/hc.21077
Autor:
S. Henry, Robert Kiss, Antonio Evidente, Ramesh Dasari, Snezna Rogelj, Ria Kidner, Florence Lefranc, Véronique Mathieu, Liliya V. Frolova, Mary R. Reisenauer, Xiaojie Yu, Andrew Brenner, Alexander Pertsemlidis, Alexander V. Aksenov, Xiuye Ma, Igor V. Magedov, Alexander Kornienko, Jerry Pelletier, David Cavazos, Regina Cencic
Publikováno v:
European journal of medicinal chemistry, 120
Plants of the Amaryllidaceae family produce a large variety of alkaloids and non-basic secondary metabolites, many of which are investigated for their promising anticancer activities. Of these, crinine-type alkaloids based on the 5,10b-ethanophenanth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3e3ad72a05755f6291272e48937e29
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/230963
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/230963
In a search of small molecules active against apoptosis-resistant cancer cells, a series of isatin-based heterocyclic compounds were synthesized and found to inhibit proliferation of cancer cell lines resistant to apoptosis. The synthesis of these co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3fbfc2d233dae7fd6f053b7f945516
https://europepmc.org/articles/PMC4775416/
https://europepmc.org/articles/PMC4775416/
Autor:
Igor V. Magedov, Alexander Kornienko
Publikováno v:
Chemistry of Heterocyclic Compounds. 48:33-38
Multicomponent reactions are emerging as a powerful tool in alkaloid-based drug discovery. This Highlight describes several recent (all published in 2011) examples of the employment of multicomponent reactions for the synthesis of biologically active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a193fe9770b72250b2c1799a01a95e
https://doi.org/10.1007/s10593-012-0965-7
https://doi.org/10.1007/s10593-012-0965-7
Autor:
Nikki Porch, Igor V. Magedov, Alexander Kornienko, Liliya V. Frolova, Kathryn Hayden, Snezna Rogelj, Indranil Malik, Hong Tang, Seth M. Daly, Katrina Lepthien
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4720-4723
A novel reaction of indole with aryldiazonium salts leading to the formation of 2-aryl-3-(arylazo)indoles was discovered. The products were found to possess potent anti-MRSA and anti-LLVRE activities. The SAR studies indicate that the potentially met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d529cf6336fdddfb6864007eebc96406
https://doi.org/10.1016/j.bmcl.2011.06.081
https://doi.org/10.1016/j.bmcl.2011.06.081