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pro vyhledávání: '"V. MAHLER"'
Autor:
Sophia C. Levis, Matthew T. Birnie, Yiyan Xie, Noriko Kamei, Puja V. Kulkarni, Johanna S. Montesinos, Christina R. Perrone, Catherine M. Cahill, Tallie Z. Baram, Stephen V. Mahler
Publikováno v:
Addiction Neuroscience, Vol 13, Iss , Pp 100175- (2024)
Opioid use disorder (OUD) is associated with a history of early-life adversity (ELA), an association that is particularly strong in women. In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in females, but
Externí odkaz:
https://doaj.org/article/8d64dd9956d94e94af54816248959924
Akademický článek
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Autor:
Matthew T. Birnie, Annabel K. Short, Gregory B. de Carvalho, Lara Taniguchi, Benjamin G. Gunn, Aidan L. Pham, Christy A. Itoga, Xiangmin Xu, Lulu Y. Chen, Stephen V. Mahler, Yuncai Chen, Tallie Z. Baram
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Reward circuit dysfunction is a mechanism for key emotional disorders that commonly arise after early life stresses (ELA). Here, the authors discover a projection from amygdala to nucleus accumbens that underlies ELA-induced reward deficits in mice.
Externí odkaz:
https://doaj.org/article/66e790ddc14546f682653fadabc8c1a6
Autor:
Sophia C. Levis, Matthew T. Birnie, Jessica L. Bolton, Christina R. Perrone, Johanna S. Montesinos, Tallie Z. Baram, Stephen V. Mahler
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract In humans, early-life adversity (ELA) such as trauma, poverty, and chaotic environment is linked to increased risk of later-life emotional disorders including depression and substance abuse. These disorders involve underlying disruption of r
Externí odkaz:
https://doaj.org/article/7d5c93c12e2b45248d0c2fbc5210959f
Publikováno v:
Addiction Neuroscience, Vol 3, Iss , Pp 100026- (2022)
Opioid addiction is a chronic, relapsing disorder. Whether addicted individuals are forced to abstain or they decide themselves to quit using drugs, relapse rates are high—especially upon encountering contexts and stimuli associated with prior opio
Externí odkaz:
https://doaj.org/article/d89c235114424b2d9a0b6f7b5a5d80d7
Autor:
D. Ferastraoaru, H. J. Bax, C. Bergmann, M. Capron, M. Castells, D. Dombrowicz, E. Fiebiger, H. J. Gould, K. Hartmann, U. Jappe, G. Jordakieva, D. H. Josephs, F. Levi-Schaffer, V. Mahler, A. Poli, D. Rosenstreich, F. Roth-Walter, M. Shamji, E. H. Steveling-Klein, M. C. Turner, E. Untersmayr, S. N. Karagiannis, E. Jensen-Jarolim
Publikováno v:
Clinical and Translational Allergy, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and
Externí odkaz:
https://doaj.org/article/36a0b020323b456eaa5ab6efccfb84e4
Autor:
V. Mahler, D. Mentzer, A. Bonertz, A. Muraro, P. Eigenmann, J. Bousquet, S. Halken, O. Pfaar, M. Jutel, U. Wahn, S. Vieths, S. Kaul
Publikováno v:
Clinical and Translational Allergy, Vol 10, Iss 1, Pp 1-7 (2020)
Abstract Concerning development of medicinal products, children belong to a so-called “special population” for which additional legislation applies: Regulation (EC) No 1901/2006 on medicinal products for paediatric use sets up a system of require
Externí odkaz:
https://doaj.org/article/a7b64716ac414b3392b67317faac2d9c
Autor:
Jordi Bonaventura, Mark A. G. Eldridge, Feng Hu, Juan L. Gomez, Marta Sanchez-Soto, Ara M. Abramyan, Sherry Lam, Matthew A. Boehm, Christina Ruiz, Mitchell R. Farrell, Andrea Moreno, Islam Mustafa Galal Faress, Niels Andersen, John Y. Lin, Ruin Moaddel, Patrick J. Morris, Lei Shi, David R. Sibley, Stephen V. Mahler, Sadegh Nabavi, Martin G. Pomper, Antonello Bonci, Andrew G. Horti, Barry J. Richmond, Michael Michaelides
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a powerful tool for neuroscience, but the standard DREADD ligand, CNO, has significant drawbacks. Here the authors report two novel high-potency DREADD ligands and a novel DREAD
Externí odkaz:
https://doaj.org/article/61041765c18b4742add3c9f64f5d7580
Publikováno v:
Frontiers in Human Neuroscience, Vol 15 (2021)
Opioid use disorder (OUD) rarely presents as a unitary psychiatric condition, and the comorbid symptoms likely depend upon the diverse risk factors and mechanisms by which OUD can arise. These factors are heterogeneous and include genetic predisposit
Externí odkaz:
https://doaj.org/article/02fcbfb377ac4142bb83fb24e4bd0a4b
Autor:
Briac Halbout, Collin Hutson, Leann Hua, Victoria Inshishian, Stephen V. Mahler, Sean B. Ostlund
Publikováno v:
Psychopharmacology, vol 240, iss 5
Rationale The endocannabinoid system makes critical contributions to reward processing, motivation, and behavioral control. Repeated exposure to THC or other cannabinoid drugs can cause persistent adaptions in the endocannabinoid system and associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a018113d7a4a8459df3e4c71e44e15
https://doi.org/10.1007/s00213-023-06352-4
https://doi.org/10.1007/s00213-023-06352-4