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Nature-inspired indolyl-2-azabicyclo[2.2.2]oct-7-ene derivatives as promising agents for the attenuation of withdrawal symptoms: synthesis of 20-desethyl-20-hydroxymethyl-11-demethoxyibogaine

Autor: Elaine Elisabetsky, Mirna Bainy Leal, V. M. Linck, Deborah C. Mash, Marisa Martinelli, I. Peretto, Alessandra Silvani, Daniele Passarella, Alessio Barilli, Giordano Lesma, Simon M. N. Efange, Bruno Danieli

Publikováno v: Natural product research. 20(8)

Microwave assisted Diels-Alder cycloaddition of 5-Br-N-benzylpyridinone (2) with methyl acrylate is described to gain an easy access to 7-bromo-2-benzyl-3-oxo-2-aza-5 or 6-carbomethoxy bicyclo[2.2.2]oct-7-enes (3)-(6). The preparation of the ibogaine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79110961e704eba92c5a42089f3607c2
https://pubmed.ncbi.nlm.nih.gov/16753910

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