Výsledky vyhledávání - "V. M. Krutiakov"

Investigation of the interaction of repair DNA polymerase β and autonomous 3′ → 5′-exonucleases TREX1 and TREX2

Autor: V. M. Krutiakov, N. V. Belyakova, N. L. Ronzhina, O. K. Legina, I. V. Shevelev

Publikováno v: Biology Bulletin. 37:464-470

The possibility of interaction of recombinant proteins of human repair DNA polymerase β with proofreading 3′ → 5′-exonucleases TREX1 and TREX2 was investigated in vitro for the first time. The results of gel filtration analysis show the format

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6eb3e818734df93bfae0690a671f7d75
https://doi.org/10.1134/s1062359010050043

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[Investigation of the interaction of repair DNA polymerase beta and autonomous 3' --5'-exonucleases TREX1 and TREX2]

Autor: N V, Beliakova, O K, Legina, N L, Ronzhina, I V, Shevelev, V M, Krutiakov

Publikováno v: Izvestiia Akademii nauk. Seriia biologicheskaia. (5)

The possibility of interaction of recombinant proteins of human repair DNA polymerase beta with proofreading 3' --5'-exonucleases TREX1 and TREX2 was investigated in vitro for the first time. The results of gel filtration analysis show the formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7698ee648e02a718de50eaf1b726c46
https://pubmed.ncbi.nlm.nih.gov/21077363

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[Ratio of 3' --5'-exonuclease and DNA-polymerase activities in normal and cancer cells of rodents and humans]

Autor: T P, Kravetskaia, N L, Ronzhina, V M, Krutiakov

Publikováno v: Tsitologiia. 52(8)

Mutations in the genes of corrective 3' --5'-exonucleases as well as in DNA polymerases lead to decrease in DNA biosynthesis accuracy all over genome. This is accompanied by the increase in mutagenesis and carcinogenesis probabilities. In this work,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b65d9250c3e3372969b09723b1229734
https://pubmed.ncbi.nlm.nih.gov/20968097

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[Complex of repair DNA polymerase beta with autonomous 3'--5'-exonuclease shows increased accuracy of DNA synthesis]

Autor: N V, Beliakova, T P, Kravetskaia, O K, Legina, N L, Ronzhina, I V, Shevelev, V M, Krutiakov

Publikováno v: Izvestiia Akademii nauk. Seriia biologicheskaia. (5)

The complexes of repair DNA polymerase beta with 3'-exonuclease and some other proteins were isolated from the chromatin of hepatocytes of normal rats for the first time. Biopolymers were extracted from the chromatin by the solution of NaCl and Trito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::834a4d9adca215757557df7ef1dab696
https://pubmed.ncbi.nlm.nih.gov/18041131

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[Eukaryotic error prone DNA polymerases: suggested roles in replication, repair and mutagenesis]

Autor: V M, Krutiakov

Publikováno v: Molekuliarnaia biologiia. 40(1)

A number of error-prone DNA polymerases is found among eukaryotes from yeasts up to mammalia including humans. According to the partial homology of a primary structure, they are united in families B, X, Y and display high infidelity on uninjured DNA-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48053c91f46d0da77f67b99b859d6105
https://pubmed.ncbi.nlm.nih.gov/16523685

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[Antimutagenic role of autonomous 3'--5'-exonucleases]

Autor: V M, Krutiakov

Publikováno v: Molekuliarnaia biologiia. 38(5)

Our own and literary data about antimutagenic role of autonomous 3'--5'-exonucleases (AE) are analyzed. AE are not bound covalently to DNA polymerases but often involved in replicative complexes. Intracellular overproduction of AE in bacteria is acco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c44b1436bae4742141b698656c1b689
https://pubmed.ncbi.nlm.nih.gov/15554185

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[The correcting role of autonomous 3'--5' exonucleases in mammalian multienzyme DNA polymerase complexes]

Autor: I V, Shevelev, N V, Beliakova, T P, Kravetskaia, V M, Krutiakov

Publikováno v: Molekuliarnaia biologiia. 36(6)

A study was made of the correcting role of autonomous 3'--5' exonucleases (AE) contained in multienzyme DNA polymerase complexes of rat hepatocytes or calf thymocytes. DNA was synthesized on phage psi X174 amber3 or M13mp2 primer-templates, and used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7e26b65262723a300f560c44845cd36
https://pubmed.ncbi.nlm.nih.gov/12500544

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