Synthesis, biological evaluation, X-ray molecular structure and molecular docking studies of RGD mimetics containing 6-amino-2,3-dihydroisoindolin-1-one fragment as ligands of integrin αIIbβ3

Autor: Janusz Lipkowski, V. M. Kabanov, Tatyana A. Kabanova, Pavel G. Polishchuk, Tetiana M. Khristova, Victor E. Kuz’min, Georgiy V. Samoylenko, Sergei A. Andronati, Marina S. Fonari, A. A. Krysko, Victor Ch. Kravtsov, Alexandre Varnek, Olga L. Krysko

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2013, 21 (15), pp.4646-4661. ⟨10.1016/j.bmc.2013.05.019⟩

A series of novel RGD mimetics containing phthalimidine fragment was designed and synthesized. Their antiaggregative activity determined by Born’s method was shown to be due to inhibition of fibrinogen binding to αIIbβ3. Molecular docking of RGD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a0c8bc7b554bbddfcbc094bc560230
https://doi.org/10.1016/j.bmc.2013.05.019

Design, Virtual Screening, and Synthesis of Antagonists of α IIb β 3 as Antiplatelet Agents

Autor: Tatyana A. Kabanova, Tetiana M. Khristova, Georgiy V. Samoylenko, Olga L. Krysko, Sergei A. Andronati, Alexandre Varnek, V. M. Kabanov, Victor E. Kuz’min, Alexander Yu. Kornylov, Thierry Langer, Olga Klimchuk, Pavel G. Polishchuk, A. A. Krysko

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (19), pp.7681-7694. ⟨10.1021/acs.jmedchem.5b00865⟩

This article describes design, virtual screening, synthesis, and biological tests of novel αIIbβ3 antagonists, which inhibit platelet aggregation. Two types of αIIbβ3 antagonists were developed: those binding either closed or open form of the pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dc92a9416499df300b22ea976f3b15
https://hal.archives-ouvertes.fr/hal-03150648

Derivatives of tetrahydroisoquinoline: Synthesis and initial evaluation of novel non-peptide antagonists of the αIIbβ3-integrin

Autor: Tatyana A. Kabanova, V. M. Kabanov, A. A. Krysko, Olga L. Krysko, Sergei A. Andronati

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:4444-4446

The novel RGDF mimetics were synthesized with the use of 4-(1,2,3,4-tetrahydroisoquinoline-7-yl)amino-4-oxobutyric or 5-(1,2,3,4-tetrahydroisoquinoline-7-yl)amino-5-oxopentanoic acids as a surrogate of Arg-Gly motif. The synthesized compounds have de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7980da5bd7d460eea65d4143a54fc5ad
https://doi.org/10.1016/j.bmcl.2010.06.051

Synthesis and distribution of HCl · Pro-Phe-[14C]-Gly-NH2 in mice

Autor: V. M. Kabanov, M. G. Rokachinskaya, N. Ya. Golovenko, Sergei A. Andronati, Mazurov Anatoly A, V. G. Zin'kovskii

Publikováno v: Pharmaceutical Chemistry Journal. 26:803-807

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51247ca914f372d47dab9d8a3fbc84f5
https://doi.org/10.1007/bf00767649

ChemInform Abstract: Synthesis and Properties of Peptidomimetics: Inhibitors of Platelet Aggregation

Autor: T. A. Kabanova, V. M. Kabanov, T. L. Karaseva, A. A. Krysko, S. A. Andronati

Publikováno v: ChemInform. 32

The literature data on effective approaches to the development of the novel peptidomimetics, antagonists of fibrinogen GP IIb/IIIa receptors as potential antithrombotic agents are generalized and systematized in the review. The data obtained by the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54a94142c0abd19ab0416f63e033bcae
https://doi.org/10.1002/chin.200134285