Stromal cells regulate malignant B-cell spatial organization, survival, and drug response in a new 3D model mimicking lymphoma tumor niche

Autor: Gaëlle Recher, N. Helaine, Céline Monvoisin, Laurence Bresson-Bepoldin, E. Dessauge, Kevin Alessandri, Frédéric Mourcin, Isabelle Mahouche, Céline Pangault, C. Lamaison, L. Broca-Brisson, Sylvain Latour, V. Le Morvan, Marine Seffals, Pierre Nassoy, Philippe Soubeyran, C. Dussert, Karin Tarte

Non-Hodgkin B-cell lymphomas (B-NHL) mainly develop within lymph nodes as densely packed aggregates of tumor cells and their surrounding microenvironment, creating a tumor niche specific to each lymphoma subtypes. Until now, in vitro preclinical mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c1c19ac602953a462b6e9222d95c5c
https://hal.archives-ouvertes.fr/hal-03010816/document

Abstract P3-12-03: Impact of genetic polymorphisms on plasma levels of tamoxifen and its metabolites and toxicity: 6-months results of the adjuvant breast cancer longitudinal PHACS study (NCT01127295)

Autor: Cécile Arellano, J-C Boyer, Fabienne Thomas, Jacques Robert, Alexandre Evrard, Melanie White-Koning, H. Roche, P Houyau, A Puzskiel, J Dauba, Christelle Vachoux, M Poublanc, Etienne Chatelut, V Le Morvan

Publikováno v: Cancer Research. 78:P3-12

Supported by a PHRC grant (#09-18-005) Background: The role of CYP2D6 genetic polymorphisms and plasma levels of active metabolites of tamoxifen (TAM) on clinical response and occurrence of side effects remains controversial. We conducted a prospecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52e8d04ad6eb564007f214fe72bc7a90
https://doi.org/10.1158/1538-7445.sabcs17-p3-12-03

The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models

Autor: V Le Morvan, Audrey Laroche-Clary, Jacques Robert, Jérôme Toutain, L Araud, Jun Kanno, Takao Yamori, N Faur

Publikováno v: British Journal of Cancer

Background: We investigated, in the panel of 60 human tumour cell lines of the National Cancer Institute (NCI-60), whether the R72P polymorphism of TP53 and the T309G polymorphism of MDM2 were associated to the in vitro cytotoxicity of anticancer age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850e3e03d3bd4ac03a281122504a5521
http://europepmc.org/articles/PMC2720206

BRCA1 haplotype and clinical benefit of trabectedin in soft-tissue sarcoma patients

Autor: Philippe Pourquier, François Bertucci, Agnès Neuville, Sébastien Salas, Roberta Sanfilippo, Antoine Italiano, Vanessa Chaire, V. Le Morvan, Audrey Laroche-Clary

Publikováno v: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2015, 112 (4), pp.688-692. ⟨10.1038/bjc.2014.624⟩
British Journal of Cancer, 2015, 112 (4), pp.688-692. ⟨10.1038/bjc.2014.624⟩

International audience; BACKGROUND : This study aimed to determine whether the BRCA1 haplotype was associated with trabectedin efficacy in soft-tissue sarcoma (STS) patients.METHODS : We analysed BRCA1 single-nucleotide polymorphisms (SNPs) in tumour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7951c8ca89b78c5f03c9cef713db76
https://www.hal.inserm.fr/inserm-02438840

Techniques de recherche des polymorphismes génétiques

Autor: Jacques Bonnet, V. Le Morvan, J.-L. Formento, G. Milano, J. Robert

Publikováno v: Oncologie. 7:7-16

Le sequencage du genome humain est a l’origine de la decouverte de millions de variations de sequence dans le genome humain. Ces variations de sequence d’ADN sont dans leur immense majorite limitees a des polymorphismes de nucleotide unique (Sing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::098ca2c1c841a3255195db59d16a9a0c
https://doi.org/10.1007/s10269-005-0146-8