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Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine

Autor: David W. Robertson, H. Wilson, E. E. Beedle, Hayes Js, G. D. Pollock, J. H. Krushinski, V. L. Wyss

Publikováno v: Journal of medicinal chemistry. 28(6)

Recently several noncatecholamine, nonglycoside cardiotonic drugs have been discovered that possess both inotropic and vasodilator activities in experimental animals and man. Prototypical compounds include amrinone, sulmazole, and fenoximone. We inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e72a9c27246f6af9d5c4728528decb
https://pubmed.ncbi.nlm.nih.gov/4009593

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ChemInform Abstract: STRUCTURE-ACTIVITY RELATIONSHIPS OF ARYLIMIDAZOPYRIDINE CARDIOTONICS: DISCOVERY AND INOTROPIC ACTIVITY OF 2-(2-METHOXY-4-(METHYLSULFINYL)PHENYL)-1H-IMIDAZO(4,5-C)PYRIDINE

Autor: E. E. Beedle, G. D. Pollock, David W. Robertson, Hayes Js, V. L. Wyss, H. Wilson, J. H. Krushinski

Publikováno v: Chemischer Informationsdienst. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee1759bc7be4b07e22c8ecd622097f6b
https://doi.org/10.1002/chin.198544198

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Molecular basis for the in vitro and in vivo cardiotonic activities of AR-L100

Autor: J S, Hayes, V L, Wyss, H C, Wilson, D W, Robertson, R F, Kauffman

Publikováno v: The Journal of pharmacology and experimental therapeutics. 239(2)

Imidazo[4,5-b]pyridines, such as AR-L57, AR-L100 and AR-L115 (Vardax), have been of interest as inotropic agents for the management of congestive heart failure. Although it has been presumed that their activities derive from inhibition of phosphodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4a1d438cd26f1719d434562c337812e
https://pubmed.ncbi.nlm.nih.gov/3021955

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Effects of prolonged isoproterenol infusion on cardiac and vascular responses to adrenoceptor agonists

Autor: J S, Hayes, V L, Wyss, K S, Schenck, M L, Cohen

Publikováno v: The Journal of pharmacology and experimental therapeutics. 237(3)

In vitro responses of cardiac and vascular smooth muscle to both adrenoceptor agonists and phosphodiesterase inhibitors were studied in tissues from either saline- or isoproterenol-infused rats. After chronic isoproterenol infusion the sigmoidal rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea981b834068339670c0dc9a4b1ec002
https://pubmed.ncbi.nlm.nih.gov/2423681

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