Zobrazeno 1 - 10
of 197
pro vyhledávání: '"V. L. Florentiev"'
Autor:
Olga F. Borisova, Galina E. Pozmogova, Igor P. Smirnov, Anton V. Aseychev, Anna K. Shchyolkina, Dmitry N. Kaluzhny, Anna M. Varizhuk, Edward N. Timofeev, S. L. Grokhovsky, V. L. Florentiev, Olga N. Tatarinova, Vladimir B. Tsvetkov
Publikováno v:
European Journal of Medicinal Chemistry. 67:90-97
A series of DNA aptamers bearing triazole internucleotide linkages that bind to thrombin was synthesized. The novel aptamers are structurally analogous to the well-known thrombin-inhibiting G-quadruplexes TBA15 and TBA31. The secondary structure stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c04bdd9acb6770a8f25ab2d01291f0
https://doi.org/10.1016/j.ejmech.2013.06.034
https://doi.org/10.1016/j.ejmech.2013.06.034
Autor:
Edward N. Timofeev, V. L. Florentiev, Alexander S. Zasedatelev, Natalia A. Kolganova, Alexander V. Chudinov, Anna K. Shchyolkina
Publikováno v:
Nucleic Acids Research
Triplex-directed DNA recognition is strictly limited by polypurine sequences. In an attempt to address this problem with synthetic biology tools, we designed a panel of short chimeric α,β-triplex-forming oligonucleotides (TFOs) and studied their in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e5f63164dfa9883c8f1fe2a13314b4
https://doi.org/10.1093/nar/gks410
https://doi.org/10.1093/nar/gks410
Publikováno v:
European Journal of Organic Chemistry. 2012:2173-2179
A new class of backbone-modified oligonucleotide analogs has emerged since the discovery of the Cu I -catalyzed [3+2] azide/alkyne cycloaddition reaction. These are oligonucleotide analogs with 1,4-disubstituted 1,2,3-triazoles as the internucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1b2421bcdcf9532ee2edd793eb8534b
https://doi.org/10.1002/ejoc.201101700
https://doi.org/10.1002/ejoc.201101700
Autor:
Natalia A. Kolganova, Edward N. Timofeev, V. L. Florentiev, S. V. Kochetkova, Alexander U. Fedotov, Anna M. Varizhuk
Publikováno v:
Letters in Organic Chemistry. 9:106-113
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a06966127ef71d746135e0a5952f349
https://doi.org/10.2174/157017812800221799
https://doi.org/10.2174/157017812800221799
Publikováno v:
Bioorganic Chemistry. 39:127-131
Triazolyl-functionalized oligonucleotide (ON) analogs have received much attention as potential antitumor and antiviral agents. The most promising of such analogs are those exhibiting high binding affinity toward native DNA/RNA, since they may prove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d88fe33e72d92bd36c7f41bb504bd36
https://doi.org/10.1016/j.bioorg.2011.03.002
https://doi.org/10.1016/j.bioorg.2011.03.002
Autor:
Anna M. Varizhuk, Natalia A. Kolganova, V. L. Florentiev, Edward N. Timofeev, S. V. Kochetkova
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 30:31-48
Oligonucleotide analogs containing one or a few glycine, L-, and D-alanine or L-and D-phenylalanine residues instead of phosphodiesterinternucleotide linkages were synthesized. The stability of the duplexes formed by modified oligonucleotides and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0955ac941d57719ad2eab05ff83dac8c
https://doi.org/10.1080/15257770.2010.542790
https://doi.org/10.1080/15257770.2010.542790
Publikováno v:
Russian Journal of Bioorganic Chemistry. 36:528-531
Oligonucleotide analogues containing one or a few glycine, L-, and D-alanine residues instead of phosphodiester internucleotide linkages were synthesized (C3′-NH-C(O)-CH(X)-NH-C(O)-C4′, where X = H, (S)-CH3, and (R)-CH3. The stability of the dupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4e3b95f53208b9a5e4308527b4ebe0
https://doi.org/10.1134/s1068162010040138
https://doi.org/10.1134/s1068162010040138
Publikováno v:
Russian Journal of Bioorganic Chemistry. 34:201-206
The synthesis of oligonucleotides containing 1-(2-deoxy-beta-D-ribofuranosyl)-2-methyl-4-nitroindole and 1-(2-deoxy-beta-D-ribofuranosyl)-2-phenyl-4-nitroindole is described. The synthesized modified oligonucleotides were used for studying the stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ff64d87181514229b08cf2f048afdb
https://doi.org/10.1134/s106816200802009x
https://doi.org/10.1134/s106816200802009x
Publikováno v:
Scopus-Elsevier
Oligonucleotide analogues bearing an acyclocytidine linked to thymidine by an amide (3'-O-CH2-CO-N-5') bond were synthesized. Melting curves of duplexes formed by modified oligonucleotides and complementary natural oligomers were obtained and thermod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a891089cfb1e5fe1ed2925b87c457ba
https://doi.org/10.1134/s1068162008020106
https://doi.org/10.1134/s1068162008020106
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 24:183-188
DNA recognition by triplex-forming oligonucleotides (TFOs) is usually limited by homopurine-homopyrimidine sequence in duplexes. Modifications of the third strand may overcome this limitation. Chimeric alpha-beta TFOs are expected to form triplex DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f43f14601aaff64bc2d847d973f2f7f
https://doi.org/10.1080/07391102.2006.10507111
https://doi.org/10.1080/07391102.2006.10507111